Entacapone
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Catechol-O-Methyltransferase Inhibitor
Controlled Drug Substance
No
entacapone
Summary
Entacapone is used to treat Parkinson's disease, which is a disorder that affects movement control. It helps manage symptoms like stiffness, tremors, and movement difficulties by enhancing the effects of other Parkinson's medications.
Entacapone works by blocking an enzyme called COMT, which breaks down levodopa in the body. This allows levodopa, a medication that improves movement control, to work longer, helping manage symptoms like stiffness and tremors.
The usual dose of Entacapone for adults is 200 mg with each dose of levodopa/carbidopa, up to eight times a day. It should be taken as directed by your doctor, usually with or without food, and not crushed or chewed.
Common side effects of Entacapone include nausea, diarrhea, and urine discoloration. These effects are usually mild and vary from person to person. If you notice new symptoms, talk with your doctor before stopping the medication.
Entacapone can cause liver problems, so regular liver function tests are recommended. It may also cause low blood pressure, leading to dizziness or fainting. Avoid if allergic to it or if you have liver disease. Consult your doctor for personalized advice.
Indications and Purpose
How does Entacapone work?
Entacapone works by blocking an enzyme called COMT, which breaks down levodopa in the body. By inhibiting this enzyme, Entacapone allows levodopa to work longer, improving movement control in people with Parkinson's disease. Think of it like a dam that slows down the flow of water, allowing more to accumulate. This helps manage symptoms like stiffness and tremors.
Is Entacapone effective?
Entacapone is effective in treating Parkinson's disease. It works by prolonging the effect of levodopa, which helps improve movement control. Clinical studies show that Entacapone can reduce "off" times, which are periods when Parkinson's symptoms return. This medication helps manage symptoms and improve quality of life for people with Parkinson's disease.
What is Entacapone?
Entacapone is a medication used to treat Parkinson's disease. It belongs to a class of drugs called COMT inhibitors, which help prolong the effect of levodopa, a medication that improves movement control. Entacapone works by blocking an enzyme that breaks down levodopa, allowing it to work longer in the body. This helps manage symptoms like stiffness and tremors in people with Parkinson's disease.
Directions for Use
For how long do I take Entacapone?
Entacapone is usually a long-term medication for managing Parkinson's disease. You'll typically take it every day as part of your treatment plan unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your symptoms to worsen. How long you'll need this medication depends on your response and overall health. Always talk with your doctor before changing or stopping your Entacapone treatment.
How do I dispose of Entacapone?
Dispose of Entacapone by taking it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away. This helps prevent harm to people and the environment.
How do I take Entacapone?
Take Entacapone as prescribed by your doctor, usually with each dose of levodopa/carbidopa. It can be taken with or without food. Do not crush or chew the tablets. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not double up on doses. Always follow your doctor's specific instructions.
How long does it take for Entacapone to start working?
Entacapone begins working shortly after you take it, helping to prolong the effect of levodopa. You may notice improved movement control within a few days. However, the full benefits may take a few weeks to appear. How quickly the medication works can depend on your overall health and response to treatment. Take it exactly as prescribed for the best results.
How should I store Entacapone?
Store Entacapone at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms, as moisture can affect the medication's effectiveness. Always keep Entacapone out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Entacapone?
The usual dose of Entacapone for adults is 200 mg with each dose of levodopa/carbidopa, up to eight times a day. Your doctor may adjust your dose based on your response and needs. There is no maximum dose for Entacapone, but it should be taken as directed by your doctor. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can Entacapone be taken safely while breastfeeding?
The safety of Entacapone while breastfeeding is not well-established. It's unclear if this medication passes into breast milk. If you're breastfeeding or planning to breastfeed, talk with your doctor about safer medication options. Your doctor can help you make informed decisions about your treatment while nursing your baby.
Can Entacapone be taken safely while pregnant?
The safety of Entacapone during pregnancy is not well-established. There is limited information on its use in pregnant women. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take Entacapone with other prescription drugs?
Entacapone can interact with certain medications, increasing the risk of side effects. It may interact with other Parkinson's medications, like levodopa, enhancing their effects. This can lead to increased side effects like dyskinesia, which is involuntary movement. Always inform your doctor about all medications you're taking to prevent interactions and ensure safe treatment.
Does Entacapone have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Entacapone include nausea, diarrhea, and urine discoloration. These effects are usually mild. Serious side effects, like liver problems or severe allergic reactions, are rare but require immediate medical attention. Always inform your doctor about any new or worsening symptoms while taking Entacapone.
Does Entacapone have any safety warnings?
Yes, Entacapone has safety warnings. It can cause liver problems, so regular liver function tests are recommended. It may also cause low blood pressure, which can lead to dizziness or fainting. If you experience symptoms like nausea, vomiting, or dark urine, contact your doctor immediately. Always follow your doctor's advice and report any unusual symptoms while taking Entacapone.
Is Entacapone addictive?
Entacapone is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Entacapone works by affecting the breakdown of levodopa in the body, which doesn't lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, Entacapone doesn't carry this risk.
Is Entacapone safe for the elderly?
Elderly individuals may be more sensitive to the side effects of Entacapone, such as low blood pressure or dizziness. It's important for older adults to be monitored closely by their doctor while taking this medication. Regular check-ups can help ensure the treatment is safe and effective. Always follow your doctor's advice and report any unusual symptoms.
Is it safe to drink alcohol while taking Entacapone?
It's best to avoid alcohol while taking Entacapone. Alcohol can increase the risk of side effects like dizziness or low blood pressure. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like dizziness or fainting. Talk with your doctor about alcohol use while taking Entacapone for personalized advice.
Is it safe to exercise while taking Entacapone?
You can exercise while taking Entacapone, but be cautious. This medication can cause dizziness or low blood pressure, which might affect your exercise capacity. To exercise safely, drink plenty of water and watch for signs of dizziness or fatigue. If you notice these symptoms, slow down or stop exercising and rest. Consult your doctor if you have concerns.
Is it safe to stop Entacapone?
Stopping Entacapone suddenly can affect your Parkinson's disease management. It may lead to a return of symptoms like stiffness or tremors. Always talk with your doctor before stopping Entacapone. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely.
What are the most common side effects of Entacapone?
Side effects are unwanted reactions to a medication. Common side effects of Entacapone include nausea, diarrhea, and urine discoloration. These effects vary from person to person. If you notice new symptoms after starting Entacapone, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Entacapone?
Don't take Entacapone if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Entacapone is not for people with liver disease, as it can worsen liver function. Use caution if you have a history of heart problems or low blood pressure. Always consult your doctor about these concerns.
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