Enasidenib
Acute Myeloid Leukemia
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Isocitrate Dehydrogenase 2 Inhibitor
Controlled Drug Substance
No
Enasidenib
Summary
Enasidenib is used to treat acute myeloid leukemia, which is a type of blood cancer, in patients with a specific genetic mutation in the IDH2 enzyme.
Enasidenib works by inhibiting the mutated IDH2 enzyme, which is involved in the growth of cancer cells. This helps to slow or stop the growth of these cells.
The usual starting dose of Enasidenib for adults is 100 mg once daily. It is taken orally, which means by mouth, and can be taken with or without food.
Common side effects of Enasidenib include nausea, vomiting, and diarrhea, which are usually mild to moderate.
Enasidenib can cause differentiation syndrome, which includes symptoms like fever and breathing difficulties. It is not recommended for pregnant or breastfeeding women due to potential risks to the baby.
Indications and Purpose
How does Enasidenib work?
Enasidenib works by inhibiting the mutated IDH2 enzyme, which is involved in the growth of cancer cells in acute myeloid leukemia. Normally, IDH2 helps cells produce energy, but when mutated, it can lead to uncontrolled cell growth. Enasidenib blocks this process, helping to slow or stop the growth of cancer cells. This targeted action makes Enasidenib effective for patients with the specific IDH2 mutation.
Is Enasidenib effective?
Enasidenib is effective for treating acute myeloid leukemia, which is a type of blood cancer, in patients with a specific genetic mutation. Clinical studies show that Enasidenib can lead to remission, which is a period when cancer symptoms are reduced or disappear, in some patients. The effectiveness of Enasidenib depends on individual factors, including the presence of the genetic mutation it targets. Your doctor will monitor your response to the medication.
What is Enasidenib?
Enasidenib is a medication used to treat acute myeloid leukemia, which is a type of blood cancer, in patients with a specific genetic mutation. It belongs to a class of drugs called IDH2 inhibitors, which work by targeting and blocking the activity of the mutated IDH2 enzyme. This helps to slow or stop the growth of cancer cells. Enasidenib is used as a targeted therapy to improve outcomes in patients with this specific mutation.
Directions for Use
For how long do I take Enasidenib?
Enasidenib is usually a long-term medication for managing acute myeloid leukemia, which is a type of blood cancer. You'll typically take Enasidenib every day as part of your cancer treatment plan unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Enasidenib treatment.
How do I dispose of Enasidenib?
If you can, bring unused Enasidenib to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Enasidenib?
Take Enasidenib as prescribed by your doctor, usually once daily. You can take it with or without food. Do not crush or chew the tablets. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for Enasidenib to start working?
Enasidenib begins working in your body shortly after you start taking it, but the full therapeutic effects may take several weeks to become noticeable. The time it takes to see results can vary based on individual factors, including the presence of the specific genetic mutation it targets. Regular monitoring by your doctor through blood tests and check-ups will help determine how well the medication is working for you.
How should I store Enasidenib?
Store Enasidenib at room temperature, away from moisture and light. Keep the medication in its original container, tightly closed, to protect it from damage. Do not store it in humid places like bathrooms. Always keep Enasidenib out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Enasidenib?
The usual starting dose of Enasidenib for adults is 100 mg once daily. Your doctor may adjust your dose based on your response to the medication and any side effects you experience. Always follow your doctor's specific dosing instructions for your personal health needs. If you have any concerns about your dose, discuss them with your healthcare provider.
Warnings and Precautions
Can Enasidenib be taken safely while breastfeeding?
Enasidenib is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. However, due to potential risks to the baby, it's best to avoid using Enasidenib while nursing. If you're taking Enasidenib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Enasidenib be taken safely while pregnant?
Enasidenib is not recommended during pregnancy due to potential risks to the unborn baby. There is limited information on its safety in pregnant women, but it may cause harm based on its effects on cell growth. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your health condition. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take Enasidenib with other prescription drugs?
Enasidenib can interact with other medications, increasing the risk of side effects or reducing effectiveness. Major interactions include drugs that affect liver enzymes, which can alter Enasidenib levels in your body. Always inform your doctor about all medications you take, including over-the-counter drugs and supplements. Your doctor can help manage potential interactions and adjust your treatment plan as needed.
Does Enasidenib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Enasidenib include nausea, vomiting, and diarrhea. These effects are usually mild to moderate. Serious adverse effects can include differentiation syndrome and elevated bilirubin levels. If you experience any new or worsening symptoms while taking Enasidenib, contact your doctor. They can help determine if these symptoms are related to the medication and provide appropriate care.
Does Enasidenib have any safety warnings?
Yes, Enasidenib has important safety warnings. It can cause differentiation syndrome, which is a serious condition that may include symptoms like fever, weight gain, and breathing difficulties. If you experience these symptoms, seek medical help immediately. Enasidenib can also cause elevated blood bilirubin levels, which may lead to jaundice, which is yellowing of the skin or eyes. Regular monitoring by your doctor is important to manage these risks.
Is Enasidenib addictive?
Enasidenib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Enasidenib works by targeting specific cancer cells and doesn't affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, you can feel confident that Enasidenib doesn't carry this risk while managing your health condition.
Is Enasidenib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Enasidenib, such as fatigue and nausea. However, Enasidenib can be used safely in older adults with careful monitoring. Your doctor will consider your overall health and any other medications you take to minimize risks. Regular check-ups are important to ensure the medication is working effectively and to manage any side effects.
Is it safe to drink alcohol while taking Enasidenib?
It's best to avoid alcohol while taking Enasidenib. Alcohol can interfere with your body's ability to process the medication and may increase the risk of side effects like nausea and liver problems. If you do choose to drink occasionally, limit how much alcohol you consume and watch for any unusual symptoms. Talk with your doctor about alcohol use while taking Enasidenib to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Enasidenib?
You can exercise while taking Enasidenib, but keep a few things in mind. This medication can cause fatigue and dizziness, which might affect your ability to exercise. To exercise safely, listen to your body and avoid strenuous activities if you feel tired or dizzy. Drink plenty of water before, during, and after physical activity. If you notice any unusual symptoms, slow down or stop exercising and rest. Check with your doctor if you have concerns about your specific situation.
Is it safe to stop Enasidenib?
Stopping Enasidenib suddenly can affect your treatment. If you're taking it for cancer, stopping could allow the cancer to progress. Always talk with your doctor before stopping Enasidenib. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
What are the most common side effects of Enasidenib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Enasidenib include nausea, vomiting, and diarrhea. These effects vary from person to person and are usually mild to moderate. If you notice new symptoms after starting Enasidenib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Enasidenib?
Do not take Enasidenib if you're allergic to it or its ingredients. Serious allergic reactions, which cause rash, hives, or swelling that makes breathing difficult, require immediate medical help. Enasidenib is not recommended for use in pregnant or breastfeeding women due to potential risks to the baby. Always consult your doctor about any concerns or conditions that might affect your use of Enasidenib.
