Empagliflozin + Linagliptin
Find more information about this combination medication at the webpages for empagliflozin and linagliptin
Type 2 Diabetes Mellitus, Cardiovascular Diseases
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Advisory
- This medicine contains a combination of 2 drugs empagliflozin and linagliptin.
- empagliflozin and linagliptin are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
None
Controlled Drug Substance
NO
empagliflozin + linagliptin
Summary
Empagliflozin and linagliptin are used to manage type 2 diabetes, which is a condition where the body does not use insulin properly, leading to high blood sugar levels. They are prescribed when diet and exercise alone are not enough to control blood sugar. Empagliflozin may also offer benefits for heart health and kidney protection in people with type 2 diabetes.
Empagliflozin helps the kidneys remove excess glucose, which is sugar, from the bloodstream through urine, lowering blood sugar levels. Linagliptin increases insulin production, which is a hormone that helps lower blood sugar, and decreases sugar production in the liver. Together, they provide a complementary approach to managing blood sugar levels effectively.
Empagliflozin is usually taken as a 10 mg dose once daily, which can be increased to 25 mg if needed. Linagliptin is typically taken as a 5 mg dose once daily. Both medications are taken orally, meaning by mouth, and can be taken with or without food. It's important to follow the healthcare provider's instructions for dosage.
Common side effects of empagliflozin include urinary tract infections and increased urination, as it removes excess glucose through urine. Linagliptin may cause a runny nose and sore throat. Both medicines can cause low blood sugar, especially when taken with other diabetes medications. Monitoring for these side effects is important.
Empagliflozin should not be used in people with severe kidney problems or those on dialysis, as it can worsen kidney function. Linagliptin is not recommended for people with a history of pancreatitis, which is inflammation of the pancreas. Both medicines should be used cautiously in people with low blood pressure or dehydration.
Indications and Purpose
How does combination of empagliflozin and linagliptin work?
Empagliflozin and linagliptin work together to help control blood sugar levels in people with type 2 diabetes. Empagliflozin acts by helping the kidneys remove excess glucose from the bloodstream through urine, which lowers blood sugar levels. Linagliptin works by increasing the amount of insulin produced by the pancreas and reducing the amount of sugar produced by the liver. Together, they provide a complementary approach to managing blood sugar levels, helping to improve overall glycemic control. Both medicines are taken orally and work best when combined with a healthy diet and regular exercise.
How does combination of Empagliflozin and Linagliptin work?
Empagliflozin works by inhibiting the sodium-glucose co-transporter 2 (SGLT2) in the kidneys, which reduces glucose reabsorption and increases glucose excretion in the urine, thereby lowering blood sugar levels. Linagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, increases the levels of incretin hormones, which enhance insulin secretion and decrease glucagon levels in a glucose-dependent manner. Together, these medications provide a dual mechanism to effectively manage blood sugar levels in patients with type 2 diabetes, addressing both insulin regulation and glucose excretion.
How effective is combination of empagliflozin and linagliptin?
Clinical studies have shown that empagliflozin and linagliptin effectively lower blood sugar levels in people with type 2 diabetes. Empagliflozin works by helping the kidneys remove excess glucose from the body, while linagliptin increases insulin production and decreases sugar production in the liver. Together, they provide a complementary approach to managing blood sugar. Evidence from trials indicates that this combination can significantly reduce HbA1c levels, which is a key marker of long-term blood sugar control. Both medicines are generally well-tolerated and offer an effective option for improving glycemic control.
How effective is combination of Empagliflozin and Linagliptin?
Clinical trials have demonstrated the effectiveness of Empagliflozin and Linagliptin in managing type 2 diabetes. Empagliflozin has been shown to significantly reduce blood sugar levels and lower the risk of cardiovascular death in patients with type 2 diabetes and cardiovascular disease. It also helps in reducing the risk of hospitalization for heart failure. Linagliptin effectively lowers blood sugar by increasing incretin hormone levels, which enhance insulin secretion. Together, these medications provide a synergistic effect, improving glycemic control and reducing the risk of diabetes-related complications. The combination has been well-studied and is supported by evidence from multiple clinical trials.
Directions for Use
What is the usual dose of combination of empagliflozin and linagliptin?
The usual adult daily dose for empagliflozin is typically 10 mg once daily, which can be increased to 25 mg if needed. Linagliptin is usually taken as a 5 mg dose once daily. Both medications are taken orally and can be taken with or without food. The exact dosage may vary based on individual health needs and response to treatment. It's important to follow the healthcare provider's instructions and not to adjust the dose without consulting them. Regular monitoring of blood sugar levels helps determine the appropriate dosage.
What is the usual dose of combination of Empagliflozin and Linagliptin?
The usual adult daily dose for Empagliflozin is either 10 mg or 25 mg, depending on the patient's needs and response to the medication. Linagliptin is typically prescribed at a dose of 5 mg per day. When combined in a single tablet, the common dosages are 10 mg of Empagliflozin with 5 mg of Linagliptin or 25 mg of Empagliflozin with 5 mg of Linagliptin. Both medications are taken once daily, usually in the morning, and can be taken with or without food. The combination aims to enhance blood sugar control in adults with type 2 diabetes by utilizing the complementary mechanisms of action of both drugs.
How does one take combination of empagliflozin and linagliptin?
Empagliflozin and linagliptin can be taken with or without food, making them convenient for daily use. There are no specific food restrictions, but it's important to maintain a balanced diet to help manage blood sugar levels effectively. Drinking plenty of water is advised to prevent dehydration, especially when taking empagliflozin. Regular monitoring of blood sugar levels is important to ensure the medication is working effectively. Always follow the healthcare provider's instructions and report any unusual symptoms or side effects.
How does one take combination of Empagliflozin and Linagliptin?
Empagliflozin and Linagliptin can be taken with or without food, typically once daily in the morning. It is important to take the medication at the same time each day to maintain consistent blood levels. Patients should follow their healthcare provider's dietary recommendations, which often include a balanced diet to help manage diabetes. While there are no specific food restrictions directly related to these medications, maintaining a healthy diet and staying hydrated is crucial. Patients should also avoid excessive alcohol consumption, as it can affect blood sugar levels and increase the risk of dehydration.
For how long is combination of empagliflozin and linagliptin taken?
Empagliflozin and linagliptin are typically used as long-term treatments for managing type 2 diabetes. The duration of use depends on individual health needs and response to treatment. Regular monitoring of blood sugar levels and periodic check-ups with a healthcare provider are essential to assess the effectiveness of the medication. Adjustments to the treatment plan may be made based on blood sugar control and any side effects experienced. It's important to continue taking the medication as prescribed to maintain its benefits.
For how long is combination of Empagliflozin and Linagliptin taken?
Empagliflozin and Linagliptin are typically used as long-term treatments for managing type 2 diabetes. They are not cures for diabetes but are intended to help control blood sugar levels over time. Patients are usually advised to continue taking these medications as part of their daily routine, alongside lifestyle changes such as diet and exercise, unless otherwise directed by their healthcare provider. Regular monitoring and consultations with a healthcare provider are essential to assess the effectiveness and adjust the treatment as needed.
How long does it take for combination of empagliflozin and linagliptin to work?
Empagliflozin and linagliptin, when taken together, start working relatively quickly to help control blood sugar levels. Empagliflozin, which helps the kidneys remove glucose from the bloodstream, can begin to show effects within a few hours. Linagliptin, which increases insulin production and decreases sugar production in the liver, also starts to work within a few hours. Both medicines work together to lower blood sugar levels, but the full effect on blood sugar control may take a few days to be noticeable. It's important to continue taking the medication as prescribed to maintain its benefits.
How long does it take for combination of Empagliflozin and Linagliptin to work?
Empagliflozin and Linagliptin, when used together, start working relatively quickly to lower blood sugar levels. Empagliflozin begins to increase urinary glucose excretion soon after ingestion, typically within hours, as it inhibits the reabsorption of glucose in the kidneys. Linagliptin, on the other hand, works by increasing the levels of incretin hormones, which help to regulate insulin and glucagon levels, thereby lowering blood sugar. While the exact time frame for noticeable effects can vary among individuals, both medications generally start to show their effects within a few days of consistent use. However, the full therapeutic benefits, especially in terms of long-term blood sugar control, may take several weeks to become evident.
Warnings and Precautions
Are there harms and risks from taking combination of empagliflozin and linagliptin?
Common side effects of empagliflozin include urinary tract infections and increased urination, as it works by removing excess glucose through urine. Linagliptin may cause side effects like a runny nose and sore throat. Both medicines can cause low blood sugar, especially when taken with other diabetes medications. Significant adverse effects include dehydration and kidney problems for empagliflozin, and pancreatitis, which is inflammation of the pancreas, for linagliptin. It's important to monitor for these side effects and consult a healthcare provider if they occur.
Are there harms and risks from taking combination of Empagliflozin and Linagliptin?
Common side effects of Empagliflozin include increased urination and thirst, while Linagliptin may cause symptoms like a stuffy or runny nose, sore throat, and cough. Both medications can lead to changes in blood sugar levels, and patients should be aware of the symptoms of both low and high blood sugar. Serious adverse effects include urinary tract infections, pancreatitis, and ketoacidosis. Empagliflozin may increase the risk of lower limb amputation and dehydration, while Linagliptin can cause severe joint pain and skin reactions. Patients should report any severe or persistent side effects to their healthcare provider immediately.
Can I take combination of empagliflozin and linagliptin with other prescription drugs?
Empagliflozin and linagliptin can interact with other prescription drugs. Empagliflozin may interact with diuretics, increasing the risk of dehydration. Linagliptin can interact with other diabetes medications, increasing the risk of low blood sugar. Both drugs may also interact with medications that affect kidney function. It's important to inform healthcare providers about all prescription medications being taken to manage potential interactions effectively. Regular monitoring of blood sugar levels and kidney function is advised to ensure safe use of these medications.
Can I take combination of Empagliflozin and Linagliptin with other prescription drugs?
Empagliflozin and Linagliptin can interact with several prescription medications. Empagliflozin may increase the risk of dehydration when taken with diuretics and can enhance the effects of insulin or insulin secretagogues, increasing the risk of hypoglycemia. Linagliptin's effectiveness can be reduced by strong inducers of CYP3A4 or P-gp, such as rifampin. Both medications require careful monitoring when used with other drugs that affect blood sugar levels. Patients should inform their healthcare provider of all medications they are taking to manage potential interactions effectively.
Can I take combination of empagliflozin and linagliptin if I am pregnant?
The safety of empagliflozin and linagliptin during pregnancy is not well-established. Empagliflozin is generally not recommended during pregnancy due to potential risks to the developing baby, particularly in the second and third trimesters. Linagliptin's effects during pregnancy are also not fully known, and it should be used only if the potential benefits justify the risks. Pregnant women should discuss with their healthcare provider to weigh the risks and benefits and consider alternative treatments for managing diabetes during pregnancy.
Can I take combination of Empagliflozin and Linagliptin if I am pregnant?
Empagliflozin and Linagliptin are not recommended during pregnancy due to potential risks to the developing fetus. Empagliflozin has shown adverse renal effects in animal studies, particularly during the second and third trimesters, which correspond to critical periods of renal development in humans. Linagliptin's effects during pregnancy are not well studied, but caution is advised. Poorly controlled diabetes during pregnancy can lead to complications, so alternative treatments that are safer during pregnancy are usually recommended. Pregnant women should discuss their treatment options with their healthcare provider to ensure the best outcomes for both mother and child.
Can I take combination of empagliflozin and linagliptin while breastfeeding?
The safety of empagliflozin and linagliptin during lactation and breastfeeding is not well-established. Empagliflozin is generally not recommended for breastfeeding mothers due to the potential risk of passing the drug to the infant through breast milk, which could affect the baby's kidney function. Linagliptin's presence in breast milk is unknown, and caution is advised. Breastfeeding mothers should consult their healthcare provider to discuss the potential risks and benefits and explore alternative treatments for managing diabetes while breastfeeding.
Can I take combination of Empagliflozin and Linagliptin while breastfeeding?
The safety of Empagliflozin and Linagliptin during lactation and breastfeeding is not well established. Empagliflozin is present in rat milk, and there is a potential risk to the developing human kidney, as human kidney maturation occurs during the first two years of life. Therefore, it is not recommended to breastfeed while taking Empagliflozin. Linagliptin's presence in human milk is also not well studied, and caution is advised. Healthcare providers typically recommend alternative treatments or advise against breastfeeding while on these medications to avoid potential risks to the infant.
Who should avoid taking combination of empagliflozin and linagliptin?
Empagliflozin and linagliptin have important warnings and contraindications. Empagliflozin should not be used in people with severe kidney problems or those on dialysis, as it can worsen kidney function. Linagliptin is not recommended for people with a history of pancreatitis. Both medicines should be used cautiously in people with a history of low blood pressure or dehydration. It's crucial to monitor for symptoms like dizziness or severe abdominal pain and consult a healthcare provider if they occur. Always inform healthcare providers of any existing health conditions before starting these medications.
Who should avoid taking combination of Empagliflozin and Linagliptin?
Empagliflozin and Linagliptin have several important warnings and contraindications. Empagliflozin is not recommended for patients with severe renal impairment or those on dialysis, as it may not be effective and can increase the risk of dehydration and ketoacidosis. Linagliptin should be used cautiously in patients with a history of pancreatitis. Both medications can cause serious allergic reactions, and patients should discontinue use and seek medical attention if they experience symptoms such as rash, swelling, or difficulty breathing. Additionally, patients should be aware of the risk of hypoglycemia, especially when used with insulin or insulin secretagogues.
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