Eltrombopag
Anemia, Aplastic, Idiopathic Thrombocytopenic Purpura
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Thrombopoietin Receptor Agonist
Controlled Drug Substance
No
Eltrombopag
Summary
Eltrombopag is used to treat low platelet counts, which are cells that help your blood clot, in conditions like chronic immune thrombocytopenia, which is a disorder causing low platelet levels, and in patients with hepatitis C to manage low platelet counts.
Eltrombopag works by stimulating the bone marrow, which is the soft tissue inside bones, to produce more platelets, which are cells that help your blood clot, thereby reducing the risk of bleeding.
The usual starting dose of Eltrombopag for adults is 50 mg once daily, taken on an empty stomach, which means either one hour before or two hours after a meal. The maximum recommended dose is 75 mg daily.
Common side effects of Eltrombopag include nausea, which is a feeling of sickness with an inclination to vomit, headache, and fatigue, which is extreme tiredness.
Eltrombopag can cause liver problems, so regular liver function tests are needed. It may also increase the risk of blood clots, which are clumps of blood that have changed from a liquid to a gel-like state.
Indications and Purpose
How does Eltrombopag work?
Eltrombopag works by stimulating the bone marrow to produce more platelets, which are cells that help your blood clot. Think of it like turning up the volume on a radio to hear the music better. This medication increases the "volume" of platelet production, helping to prevent bleeding in people with low platelet counts. It is used in conditions like chronic immune thrombocytopenia and hepatitis C.
Is Eltrombopag effective?
Eltrombopag is effective in increasing platelet counts in people with certain conditions like chronic immune thrombocytopenia, which is a disorder causing low platelet levels. Clinical studies show Eltrombopag significantly improves platelet counts, reducing the risk of bleeding. It is also used in patients with hepatitis C to manage low platelet counts. Always follow your doctor's advice to ensure the best outcomes.
What is Eltrombopag?
Eltrombopag is a medication used to increase platelet counts in people with certain conditions like chronic immune thrombocytopenia, which is a disorder causing low platelet levels. It works by stimulating the bone marrow to produce more platelets. Eltrombopag is also used in patients with hepatitis C to manage low platelet counts. It is usually taken as a tablet once daily.
Directions for Use
For how long do I take Eltrombopag?
Eltrombopag is usually a long-term medication for managing conditions like chronic immune thrombocytopenia. You'll typically take Eltrombopag every day as a lifelong treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Eltrombopag treatment.
How do I dispose of Eltrombopag?
If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Eltrombopag?
Eltrombopag is usually taken once daily on an empty stomach, either one hour before or two hours after a meal. It should not be crushed or mixed with food. Avoid taking it with dairy products or mineral supplements, as they can interfere with absorption. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose. Never take two doses at once.
How long does it take for Eltrombopag to start working?
Eltrombopag begins working in your body shortly after you take it, but it may take one to two weeks to see an increase in platelet counts. The full therapeutic effect can take several weeks. How quickly the medication works can depend on your condition and overall health. Take it exactly as prescribed for the best results.
How should I store Eltrombopag?
Store Eltrombopag at room temperature, away from moisture and light. Keep it in its original container, tightly closed, to protect it from damage. Don't store it in humid places like bathrooms, where moisture in the air could affect how well the medication works. Always store Eltrombopag out of children's reach to prevent accidental swallowing.
What is the usual dose of Eltrombopag?
The usual starting dose of Eltrombopag for adults is 50 mg once daily. The dose may be adjusted based on your platelet count and response to the medication. The maximum recommended dose is 75 mg daily. For children or the elderly, dose adjustments may be necessary. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can Eltrombopag be taken safely while breastfeeding?
The safety of Eltrombopag while breastfeeding is not well-established. It's unclear if this medication passes into breast milk. If you're taking Eltrombopag and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely. Your doctor can help determine the best approach for your situation.
Can Eltrombopag be taken safely while pregnant?
The safety of Eltrombopag during pregnancy is not well-established. Limited data is available, and the effects on an unborn baby are not fully known. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take Eltrombopag with other prescription drugs?
Eltrombopag can interact with certain medications, increasing the risk of adverse effects. Drugs like antacids containing aluminum, calcium, or magnesium can reduce Eltrombopag's effectiveness. To prevent this, take Eltrombopag at least two hours before or four hours after these medications. Always inform your doctor about all the medications you are taking to avoid potential interactions.
Does Eltrombopag have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Eltrombopag include nausea, headache, and fatigue. Serious side effects can include liver problems and blood clots. If you notice symptoms like yellowing of the skin or eyes, dark urine, or unusual bruising, contact your doctor immediately. Always inform your doctor about any new or worsening symptoms while taking Eltrombopag.
Does Eltrombopag have any safety warnings?
Eltrombopag has important safety warnings. It can cause liver problems, so regular liver function tests are needed. Not adhering to these warnings can lead to serious liver damage. Eltrombopag may also increase the risk of blood clots. If you experience symptoms like yellowing of the skin or eyes, dark urine, or unusual bruising, seek medical help immediately. Always follow your doctor's advice and attend all scheduled check-ups.
Is Eltrombopag addictive?
Eltrombopag is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Eltrombopag works by increasing platelet production and doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Eltrombopag safe for the elderly?
Eltrombopag can be used in elderly patients, but caution is advised due to the potential for increased sensitivity to the drug. Elderly patients may have a higher risk of side effects, including liver function abnormalities and thromboembolic events. Regular monitoring of liver function and platelet counts is recommended. It's important for elderly patients to discuss their overall health and any other medications they are taking with their healthcare provider to ensure safe use of Eltrombopag.
Is it safe to drink alcohol while taking Eltrombopag?
It's best to avoid alcohol while taking Eltrombopag. Alcohol can increase the risk of liver problems, which is a concern with Eltrombopag. Drinking alcohol may also worsen side effects like dizziness or nausea. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like unusual fatigue or yellowing of the skin. Talk with your doctor about alcohol use while taking Eltrombopag.
Is it safe to exercise while taking Eltrombopag?
You can exercise while taking Eltrombopag, but keep a few things in mind. This medication can cause dizziness or fatigue, which might affect your exercise capacity. To exercise safely, drink plenty of water before, during, and after physical activity. Watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest. Most people can maintain their regular exercise routine while taking Eltrombopag.
Is it safe to stop Eltrombopag?
Stopping Eltrombopag suddenly can cause your platelet levels to drop, increasing the risk of bleeding. It's important to follow your doctor's instructions when stopping this medication. Your doctor may suggest gradually reducing your dose to prevent complications. Always talk with your doctor before stopping Eltrombopag to ensure your health condition remains stable.
What are the most common side effects of Eltrombopag?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Eltrombopag include nausea, headache, and fatigue. These effects vary from person to person. If you notice new symptoms after starting Eltrombopag, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Eltrombopag?
Don't take Eltrombopag if you're allergic to it or its ingredients. Serious allergic reactions, which cause rash, hives, or swelling that makes breathing difficult, require immediate medical help. Eltrombopag shouldn't be used by people with severe liver problems, as it can worsen liver function. Always consult your doctor about these concerns.
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