Elacestrant
Breast Neoplasms
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Estrogen Receptor Antagonist
Controlled Drug Substance
No
Elacestrant
Summary
Elacestrant is used to treat hormone receptor-positive breast cancer in adults, particularly postmenopausal women and men, who have seen disease progression after other hormone therapies.
Elacestrant is an estrogen receptor antagonist. It works by binding to the estrogen receptors and blocking estrogen from attaching to them. This is crucial in stopping the growth of certain breast cancer cells that depend on estrogen.
The usual daily dose for adults is 345 mg, taken orally with food once daily. The tablets should be swallowed whole without chewing, crushing, or splitting them.
Common side effects of Elacestrant include musculoskeletal pain, nausea, fatigue, vomiting, and diarrhea. Serious adverse effects can include severe musculoskeletal pain and nausea.
Elacestrant may cause fetal harm if administered to pregnant women. It may also pass into breast milk, so breastfeeding is not recommended during treatment and for one week after the last dose. The drug is contraindicated in patients with severe hepatic impairment.
Indications and Purpose
How does Elacestrant work?
Elacestrant works by blocking estrogen receptors, which are proteins that can promote the growth of certain cancer cells. By blocking these receptors, Elacestrant helps slow or stop the growth of cancer cells. Think of it like turning off a switch that allows cancer cells to grow. This action makes Elacestrant effective in treating certain types of breast cancer.
Is Elacestrant effective?
Elacestrant is effective for its approved uses. Clinical studies support its effectiveness in treating certain conditions. Your doctor will monitor your health to ensure the medication is working as intended. If you have concerns about its effectiveness, discuss them with your healthcare provider.
What is Elacestrant?
Elacestrant is a medication used to treat certain types of breast cancer. It works by blocking estrogen receptors, which are proteins that can promote the growth of cancer cells. Elacestrant is typically used when other treatments have not been effective. It is part of a class of drugs called selective estrogen receptor degraders, which help slow or stop the growth of cancer cells.
Directions for Use
For how long do I take Elacestrant?
Elacestrant is usually taken long-term for managing certain health conditions. The duration of use depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your Elacestrant treatment. They will guide you on the appropriate duration based on your health needs.
How do I dispose of Elacestrant?
Dispose of Elacestrant by taking it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, mix the medication with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away in the trash. This helps prevent harm to people and the environment.
How do I take Elacestrant?
Take Elacestrant as prescribed by your doctor, usually once daily. You can take it with or without food. Do not crush or chew the medication. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Follow your doctor's advice on any dietary or beverage restrictions.
How long does it take for Elacestrant to start working?
Elacestrant begins working in your body shortly after you take it. However, the time it takes to notice its full effects can vary. Some people may see improvements in their condition within weeks, while for others, it may take longer. How quickly Elacestrant works can depend on your overall health and how your body responds to the medication. Follow your doctor's instructions for the best results.
How should I store Elacestrant?
Store Elacestrant at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. Always keep Elacestrant out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Elacestrant?
The usual starting dose of Elacestrant for adults is determined by your doctor based on your specific health needs. It's typically taken once daily. Your doctor may adjust your dose if needed. Always follow your doctor's specific dosing instructions. Elacestrant is not typically used in children or the elderly without specific medical advice.
Warnings and Precautions
Can Elacestrant be taken safely while breastfeeding?
Elacestrant is not recommended while breastfeeding. Limited information is available about whether it passes into human breast milk. If you're taking Elacestrant and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Elacestrant be taken safely while pregnant?
Elacestrant isn't recommended during pregnancy. Limited information is available about its safety in pregnant women. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your health condition. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take Elacestrant with other prescription drugs?
Avoid using Elacestrant with strong or moderate CYP3A4 inducers and inhibitors, as they can alter Elacestrant's effectiveness and increase the risk of side effects. Consult your doctor about all medications you are taking to avoid potential interactions.
Does Elacestrant have adverse effects?
Adverse effects are unwanted reactions to a medication. Elacestrant can cause side effects, but most people tolerate it well. Common adverse effects include nausea and fatigue. Serious side effects are rare but require immediate medical attention. Always inform your doctor about any new or worsening symptoms while taking Elacestrant.
Does Elacestrant have any safety warnings?
Elacestrant has important safety warnings. It can cause side effects that require medical attention. Always follow your doctor's instructions and report any unusual symptoms. Not adhering to safety warnings can lead to serious health issues. If you experience any concerning symptoms, contact your healthcare provider immediately.
Is Elacestrant addictive?
Elacestrant is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. This medication works without affecting brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, you can feel confident that Elacestrant doesn't carry this risk.
Is Elacestrant safe for the elderly?
No overall differences in safety or effectiveness of Elacestrant were observed between patients 65 years or older compared to younger patients. However, there are insufficient data for patients 75 years or older to assess differences in safety or effectiveness. Elderly patients should be monitored closely for side effects.
Is it safe to drink alcohol while taking Elacestrant?
It's best to avoid alcohol while taking Elacestrant. Alcohol can interfere with the medication and increase the risk of side effects. If you choose to drink occasionally, limit your alcohol intake and watch for any warning signs. Talk with your doctor about alcohol use while taking Elacestrant for personalized advice.
Is it safe to exercise while taking Elacestrant?
You can exercise while taking Elacestrant, but be mindful of how your body feels. This medication can cause dehydration, so drink plenty of water before, during, and after exercise. If you feel dizzy or weak, slow down or stop exercising and rest. Consult your doctor if you have concerns about exercising while on Elacestrant.
Is it safe to stop Elacestrant?
Stopping Elacestrant suddenly can cause issues with your health condition. Always talk with your doctor before stopping the medication. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely.
What are the most common side effects of Elacestrant?
Side effects are unwanted reactions to a medication. Common side effects of Elacestrant include nausea and fatigue. These effects vary from person to person. If you notice new symptoms after starting Elacestrant, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Elacestrant?
Don't take Elacestrant if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Elacestrant should be used with caution in certain conditions. Always consult your doctor about any concerns or existing health conditions before starting Elacestrant.
