Droxidopa
Orthostatic Hypotension
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Summary
Droxidopa is used to treat neurogenic orthostatic hypotension, which is a condition where blood pressure drops when standing, causing dizziness and lightheadedness.
Droxidopa works by increasing norepinephrine levels, which is a chemical that helps maintain blood pressure by narrowing blood vessels.
The usual starting dose of Droxidopa for adults is 100 mg three times a day, with a maximum of 600 mg three times a day. It is taken orally.
Common side effects of Droxidopa include headache, dizziness, and nausea, which are usually mild and temporary.
Droxidopa can increase blood pressure, so regular monitoring is essential. It is contraindicated in patients with uncontrolled hypertension, which is high blood pressure.
Indications and Purpose
How does Droxidopa work?
Droxidopa works by increasing norepinephrine levels in the body, which helps maintain blood pressure. Norepinephrine is a chemical that narrows blood vessels, increasing blood pressure. Think of it like turning up the volume on a speaker to hear better. By boosting norepinephrine, Droxidopa helps prevent blood pressure from dropping when you stand up, reducing symptoms like dizziness.
Is Droxidopa effective?
Droxidopa is effective in treating neurogenic orthostatic hypotension, which is a condition where blood pressure drops when standing. It works by increasing norepinephrine levels, which helps maintain blood pressure. Clinical studies show Droxidopa improves symptoms like dizziness and lightheadedness in patients with this condition. Always follow your doctor's instructions to achieve the best results.
What is Droxidopa?
Droxidopa is a medication used to treat neurogenic orthostatic hypotension, which is a condition where blood pressure drops when standing. It belongs to a class of drugs called norepinephrine precursors. Droxidopa works by increasing norepinephrine levels, which helps maintain blood pressure. This medication is often used in combination with other therapies to manage symptoms effectively.
Directions for Use
For how long do I take Droxidopa?
Droxidopa is usually a long-term medication for managing neurogenic orthostatic hypotension, which is a drop in blood pressure when standing. You'll typically take Droxidopa every day as a lifelong treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Droxidopa treatment.
How do I dispose of Droxidopa?
Dispose of Droxidopa by taking it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Droxidopa?
Take Droxidopa as prescribed by your doctor. It's usually taken three times a day, with or without food. Swallow the capsules whole; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not double up on doses. Follow any dietary or beverage restrictions your doctor advises.
How long does it take for Droxidopa to start working?
Droxidopa begins working shortly after you take it, with effects noticeable within a few hours. However, the full therapeutic effect may take a few days to become apparent. Individual factors like your overall health and the severity of your condition can affect how quickly you notice improvements. Take Droxidopa exactly as prescribed for the best results.
How should I store Droxidopa?
Store Droxidopa at room temperature, away from moisture and light. Keep it in a tightly closed container. Avoid storing it in humid places like bathrooms, as moisture can affect the medication's effectiveness. Always keep Droxidopa out of children's reach to prevent accidental ingestion. Check the expiration date regularly and dispose of any unused or expired medication properly.
What is the usual dose of Droxidopa?
The usual starting dose of Droxidopa for adults is 100 mg three times a day. Your doctor may adjust your dose based on your response and needs. The maximum recommended dose is 600 mg three times a day. Always follow your doctor's specific dosing instructions. Special populations, such as the elderly, may require dose adjustments and careful monitoring.
Warnings and Precautions
Can Droxidopa be taken safely while breastfeeding?
The safety of Droxidopa while breastfeeding is not well-established. It's unclear if Droxidopa passes into breast milk or affects milk production. If you're breastfeeding or planning to breastfeed, talk with your doctor about the safest treatment options. They can help determine the best approach for managing your condition while ensuring your baby's safety.
Can Droxidopa be taken safely while pregnant?
The safety of Droxidopa during pregnancy is not well-established. Limited data is available, so it's important to weigh the benefits and risks with your doctor. If you're pregnant or planning to become pregnant, discuss the safest treatment options for your condition with your healthcare provider. They can help create a plan that protects both you and your baby.
Can I take Droxidopa with other prescription drugs?
Droxidopa can interact with certain medications, increasing the risk of high blood pressure. Be cautious when taking it with drugs that raise blood pressure, like certain antidepressants. Always inform your doctor about all medications you're taking to avoid interactions. They can help adjust your treatment plan to ensure safety and effectiveness.
Does Droxidopa have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Droxidopa include headache, dizziness, and nausea. These effects are usually mild. Serious side effects, like high blood pressure, are less common but require immediate medical attention. If you notice any new or worsening symptoms, contact your doctor. They can help determine if these symptoms are related to Droxidopa and suggest appropriate actions.
Does Droxidopa have any safety warnings?
Yes, Droxidopa has important safety warnings. It can increase blood pressure, so regular monitoring is essential. Not adhering to these warnings can lead to serious cardiovascular issues. If you experience symptoms like severe headache, chest pain, or shortness of breath, seek medical help immediately. Always follow your doctor's advice and report any unusual symptoms.
Is Droxidopa addictive?
Droxidopa is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Droxidopa works by affecting your body's ability to produce norepinephrine, which helps regulate blood pressure. This mechanism doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Droxidopa safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Droxidopa, such as increased blood pressure. It's important to monitor blood pressure regularly and adjust the dose as needed. The elderly may also be at higher risk for dizziness and falls. Always consult your doctor for personalized advice and monitoring while taking Droxidopa.
Is it safe to drink alcohol while taking Droxidopa?
It's best to avoid alcohol while taking Droxidopa. Alcohol can increase the risk of side effects like dizziness and low blood pressure. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like dizziness or fainting. Talk with your doctor about alcohol use while taking Droxidopa to get personalized advice based on your health situation.
Is it safe to exercise while taking Droxidopa?
You can exercise while taking Droxidopa, but be cautious. This medication can cause dizziness, especially when standing up quickly. To exercise safely, start slowly and avoid sudden movements. Drink plenty of water before, during, and after physical activity. If you feel dizzy or lightheaded, stop exercising and rest. Talk with your doctor if you have concerns about your exercise routine.
Is it safe to stop Droxidopa?
Stopping Droxidopa suddenly can cause your symptoms to return or worsen. It's usually used for long-term management of conditions like neurogenic orthostatic hypotension, which is a drop in blood pressure when standing. Always talk with your doctor before stopping Droxidopa. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control.
What are the most common side effects of Droxidopa?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Droxidopa include headache, dizziness, and nausea. These effects vary from person to person and are usually mild. If you notice new symptoms after starting Droxidopa, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Droxidopa?
Don't take Droxidopa if you're allergic to it or its ingredients. It's contraindicated in patients with uncontrolled hypertension, which is high blood pressure, due to the risk of exacerbating this condition. Use caution if you have a history of heart disease. Always consult your doctor about these concerns before starting Droxidopa.
