Dorzolamide
Open-Angle Glaucoma
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Carbonic Anhydrase Inhibitor
Controlled Drug Substance
No
Summary
Dorzolamide is used to treat elevated eye pressure, which can lead to glaucoma, a condition that damages the optic nerve and can cause vision loss.
Dorzolamide works by inhibiting carbonic anhydrase, which is an enzyme that reduces fluid production in the eye, thereby lowering eye pressure.
Dorzolamide is usually administered as an eye drop, with the typical dosage being one drop in the affected eye(s) three times a day.
Common side effects of dorzolamide include mild eye discomfort, burning, or stinging, which are usually temporary.
Dorzolamide should not be used by individuals with severe kidney problems or allergies to its ingredients, as it may worsen these conditions.
Indications and Purpose
How does dorzolamide work?
Dorzolamide works by inhibiting an enzyme called carbonic anhydrase, which reduces fluid production in the eye. This action decreases eye pressure, similar to turning down a faucet to reduce water flow. By lowering pressure, dorzolamide helps prevent damage to the optic nerve and vision loss in conditions like glaucoma.
Is dorzolamide effective?
Dorzolamide is effective in reducing elevated eye pressure, which helps manage conditions like glaucoma. It works by decreasing fluid production in the eye, leading to lower pressure. Clinical studies support its effectiveness in controlling eye pressure and preventing vision loss. Always use dorzolamide as prescribed by your doctor for the best results.
What is dorzolamide?
Dorzolamide is a medication used to lower eye pressure in conditions like glaucoma. It belongs to a class of drugs called carbonic anhydrase inhibitors, which reduce fluid production in the eye. This helps decrease pressure and prevent vision loss. Dorzolamide is typically used as an eye drop and can be part of a combination therapy with other medications.
Directions for Use
For how long do I take dorzolamide?
Dorzolamide is usually a long-term medication for managing ongoing eye conditions like glaucoma. You'll typically use dorzolamide every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your condition to worsen. Always talk with your doctor before changing or stopping your dorzolamide treatment.
How do I dispose of dorzolamide?
If you can, bring unused dorzolamide to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw it in the trash at home. But first, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take dorzolamide?
Dorzolamide is usually administered as an eye drop. You should use it as directed by your doctor, typically one drop in the affected eye(s) three times a day. Do not crush or ingest the drops. If you miss a dose, apply it as soon as you remember unless it's almost time for your next dose. Then skip the missed dose and continue your regular schedule. Avoid touching the dropper tip to any surface to prevent contamination.
How long does it take for dorzolamide to start working?
Dorzolamide starts working within hours of application, helping to lower eye pressure. However, the full therapeutic effect may take a few days to become noticeable. Consistent use as prescribed is important for maintaining its benefits. If you have concerns about how quickly dorzolamide is working, discuss them with your doctor.
How should I store dorzolamide?
Store dorzolamide at room temperature, away from light and moisture. Keep the bottle tightly closed when not in use. Avoid storing it in humid places like bathrooms. Always keep dorzolamide out of children's reach to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of dorzolamide?
The usual dose of dorzolamide for adults is one drop in the affected eye(s) three times a day. This frequency helps manage eye pressure effectively. Always follow your doctor's specific dosing instructions. If you have any concerns or experience side effects, consult your healthcare provider for guidance.
Warnings and Precautions
Can dorzolamide be taken safely while breastfeeding?
The safety of dorzolamide while breastfeeding isn't well-established. It's unclear if this medication passes into breast milk. If you're breastfeeding or planning to breastfeed, talk with your doctor about the safest treatment options for managing your eye condition. They can help you make an informed decision that protects both you and your baby.
Can dorzolamide be taken safely while pregnant?
The safety of dorzolamide during pregnancy isn't well-established. Limited data is available, so it's important to weigh the benefits and risks with your doctor. If you're pregnant or planning to become pregnant, discuss the safest treatment options for managing your eye condition with your healthcare provider.
Can I take dorzolamide with other prescription drugs?
Dorzolamide may interact with other eye medications, especially those that also lower eye pressure. Combining these can increase the risk of side effects. Always inform your doctor about all medications you're using, including eye drops, to avoid potential interactions. Your doctor can help manage your treatment safely.
Does dorzolamide have adverse effects?
Adverse effects are unwanted reactions to a medication. With dorzolamide, common adverse effects include eye discomfort or burning. These effects are usually mild. Serious side effects, like severe eye pain or vision changes, are rare but require immediate medical attention. Always inform your doctor about any new or worsening symptoms while using dorzolamide.
Does dorzolamide have any safety warnings?
Dorzolamide has important safety warnings. It can cause eye irritation or allergic reactions. If you experience severe eye pain, redness, or vision changes, seek medical help. Avoid using dorzolamide if you have severe kidney problems, as it may worsen your condition. Always follow your doctor's instructions and report any unusual symptoms.
Is dorzolamide addictive?
Dorzolamide is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop using it. It works by reducing eye pressure and doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to use more than prescribed.
Is dorzolamide safe for the elderly?
Elderly individuals may be more sensitive to the effects of dorzolamide. They might experience side effects like eye irritation or discomfort more frequently. It's important for elderly users to have regular check-ups with their doctor to monitor their response to the medication. Always follow your doctor's guidance when using dorzolamide.
Is it safe to drink alcohol while taking dorzolamide?
There's no well-established interaction between dorzolamide and alcohol. However, it's always best to consume alcohol in moderation and discuss any concerns with your doctor. Alcohol can sometimes cause dehydration, which may affect your overall health. If you have specific questions about alcohol use while taking dorzolamide, consult your healthcare provider.
Is it safe to exercise while taking dorzolamide?
You can exercise while using dorzolamide. This medication doesn't typically limit exercise capacity. However, if you experience dizziness or unusual fatigue, take a break and rest. Stay hydrated and listen to your body during physical activity. If you have concerns about exercising while using dorzolamide, consult your doctor for personalized advice.
Is it safe to stop dorzolamide?
It's important to consult your doctor before stopping dorzolamide. Stopping suddenly can lead to increased eye pressure, which may harm your vision. Your doctor might suggest a gradual reduction or an alternative treatment to manage your condition safely. Always follow your doctor's guidance when making changes to your medication.
What are the most common side effects of dorzolamide?
Side effects are unwanted reactions that can happen when taking a medication. With dorzolamide, common side effects include eye discomfort, burning, or stinging. These effects are usually mild and temporary. If you notice new symptoms after starting dorzolamide, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking dorzolamide?
Don't use dorzolamide if you're allergic to it or its ingredients. Serious allergic reactions, which cause rash, hives, or swelling that makes breathing difficult, require immediate medical help. Dorzolamide shouldn't be used by people with severe kidney problems, as it might worsen kidney function. Always consult your doctor about these concerns.
