Dolutegravir + Lamivudine
Find more information about this combination medication at the webpages for Dolutegravir and Lamivudine
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Advisory
- This medicine contains a combination of 2 drugs Dolutegravir and Lamivudine.
- Dolutegravir and Lamivudine are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
None
Controlled Drug Substance
NO
Summary
Dolutegravir and Lamivudine are used together to treat HIV-1 infection, which is a type of virus that attacks the immune system, in adults and adolescents who have not been treated with HIV medications before or who have a stable viral load. This combination helps reduce the amount of HIV in the blood, preventing the progression to AIDS, which is a severe stage of HIV infection that leads to a weakened immune system and increased risk of infections and cancers.
Dolutegravir works by blocking the integrase enzyme, which is a protein that helps the virus insert its genetic material into the DNA of human cells, stopping the virus from multiplying. Lamivudine works by inhibiting the reverse transcriptase enzyme, which is a protein that helps the virus convert its RNA into DNA, a crucial step for viral replication. Together, they effectively reduce the viral load, which is the amount of virus in the blood, helping to control the infection and prevent disease progression.
The usual adult daily dose for the combination of Dolutegravir and Lamivudine is one tablet taken orally once a day. Each tablet contains 50 mg of Dolutegravir and 300 mg of Lamivudine. This fixed-dose combination is designed to simplify the treatment regimen by combining both active ingredients into a single tablet, ensuring that patients receive the correct dose of each medication. It is important to take the medication exactly as prescribed by a healthcare provider to maintain effective viral suppression.
Common side effects of Dolutegravir and Lamivudine include headache, nausea, diarrhea, trouble sleeping, tiredness, and anxiety. These are generally mild and may improve as your body adjusts to the medication. However, significant adverse effects can include hypersensitivity reactions, which are severe allergic reactions, liver problems, and lactic acidosis, which is a buildup of lactic acid in the body that can be serious. Patients should be aware of symptoms such as rash, fever, or jaundice, and seek medical attention if they occur.
Dolutegravir and Lamivudine should not be taken with dofetilide, a medication used to treat irregular heartbeats, due to the risk of serious side effects. Patients with a history of hepatitis B or C should be closely monitored, as stopping Lamivudine can lead to severe exacerbations of hepatitis B. Additionally, Dolutegravir has been associated with a small risk of neural tube defects when taken at conception. Patients should inform their healthcare provider of any allergies or medical conditions before starting treatment, and breastfeeding is generally not recommended due to the risk of transmitting HIV to the infant.
Indications and Purpose
How does combination of Dolutegravir and Lamivudine work?
The combination of Dolutegravir and Lamivudine is used to treat HIV, the virus that causes AIDS. Dolutegravir is an integrase inhibitor, which means it blocks the virus from integrating its genetic material into human cells, a crucial step in the virus's replication process. Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI), which works by blocking reverse transcriptase, an enzyme the virus needs to make copies of itself. Together, these drugs help reduce the amount of HIV in the body, maintain a healthy immune system, and decrease the risk of developing HIV-related illnesses.
How does combination of Lamivudine and Dolutegravir work?
Lamivudine and dolutegravir work by targeting different stages of the HIV replication cycle. Lamivudine is a nucleoside analogue reverse transcriptase inhibitor (NRTI) that prevents the virus from converting its RNA into DNA, a crucial step for viral replication. Dolutegravir is an integrase strand transfer inhibitor (INSTI) that blocks the integrase enzyme, preventing the integration of viral DNA into the host cell's genome. Together, they effectively reduce the viral load in the body, helping to control the infection and prevent disease progression.
How effective is combination of Dolutegravir and Lamivudine?
The combination of Dolutegravir and Lamivudine is an effective treatment for HIV. Dolutegravir is an integrase inhibitor, which means it blocks the virus from integrating its genetic material into human cells, a crucial step in the virus's replication process. Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI), which prevents the virus from making copies of itself. Together, these drugs work to reduce the amount of HIV in the body, helping to keep the immune system healthy and reducing the risk of HIV-related illnesses. According to the NHS and other trusted sources, this combination is generally well-tolerated and effective in achieving viral suppression in many patients.
How effective is combination of Lamivudine and Dolutegravir?
The effectiveness of lamivudine and dolutegravir is supported by clinical trials that demonstrate their ability to significantly reduce viral load in patients with HIV-1. Studies have shown that this combination can achieve and maintain viral suppression in treatment-naïve patients and those who are virologically suppressed on a stable regimen. The unique action of lamivudine as an NRTI and dolutegravir as an INSTI provides a dual mechanism of action that effectively inhibits viral replication, leading to improved immune function and reduced risk of HIV-related complications.
Directions for Use
What is the usual dose of combination of Dolutegravir and Lamivudine?
The usual dose of the combination of Dolutegravir and Lamivudine for adults is one tablet taken once daily. This combination is used to treat HIV infection. Dolutegravir is an antiretroviral medication that helps to prevent the virus from multiplying, while Lamivudine is another antiretroviral that works by blocking the virus's ability to replicate. It's important to follow the healthcare provider's instructions and not to change the dose without consulting them.
What is the usual dose of combination of Lamivudine and Dolutegravir?
The usual adult daily dose for the combination of lamivudine and dolutegravir is one tablet taken orally once a day. Each tablet contains 50 mg of dolutegravir and 300 mg of lamivudine. This fixed-dose combination is designed to simplify the treatment regimen by combining both active ingredients into a single tablet, ensuring that patients receive the correct dose of each medication. It is important to take the medication exactly as prescribed by a healthcare provider to maintain effective viral suppression.
How does one take combination of Dolutegravir and Lamivudine?
Dolutegravir and Lamivudine are taken together as a single tablet, usually once a day. It is important to follow the dosage instructions provided by your healthcare provider. This combination is used to treat HIV, and it works by reducing the amount of virus in the body, helping the immune system to function better. Always take the medication at the same time each day to maintain an even level in your bloodstream. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. Do not double up on doses. For more detailed information, you can refer to trusted sources like the NHS or NLM.
How does one take combination of Lamivudine and Dolutegravir?
Lamivudine and dolutegravir can be taken with or without food, but it is important to take the medication at the same time every day to maintain consistent drug levels in the body. If taking antacids or supplements containing calcium or iron, these should be taken at least 2 hours after or 6 hours before the medication to avoid interactions. Patients should follow their healthcare provider's instructions and not alter the dosage or stop taking the medication without consulting their doctor.
For how long is combination of Dolutegravir and Lamivudine taken?
The combination of Dolutegravir and Lamivudine is typically taken as a long-term treatment for HIV. The exact duration can vary depending on individual health conditions and response to the medication. It is important to follow the healthcare provider's instructions and not stop taking the medication without consulting them, as it is used to manage HIV infection effectively.
For how long is combination of Lamivudine and Dolutegravir taken?
Lamivudine and dolutegravir are typically used as a long-term treatment for HIV-1 infection. Patients are advised to continue taking the medication daily as prescribed by their healthcare provider, even if they feel well, to maintain viral suppression and prevent the progression of the disease. The duration of use is generally indefinite, as there is currently no cure for HIV, and ongoing treatment is necessary to manage the infection effectively.
How long does it take for combination of Dolutegravir and Lamivudine to work?
The combination of Dolutegravir and Lamivudine is used to treat HIV. According to the NHS, it can take a few weeks for the medication to start reducing the amount of HIV in your body. However, it may take several months for your immune system to improve and for you to feel better. It's important to take the medication exactly as prescribed and attend regular check-ups to monitor your progress.
How long does it take for combination of Lamivudine and Dolutegravir to work?
Lamivudine and dolutegravir work together to reduce the amount of HIV in the blood. While the exact time it takes for the combination to start working can vary, patients may begin to see a reduction in viral load within a few weeks of starting treatment. Dolutegravir, an integrase strand transfer inhibitor, and lamivudine, a nucleoside analogue reverse transcriptase inhibitor, both act to inhibit the replication of the virus, which helps in reducing the viral load. However, the full effect in terms of viral suppression might take several weeks to months, depending on individual response and adherence to the medication regimen.
Warnings and Precautions
Are there harms and risks from taking combination of Dolutegravir and Lamivudine?
Dolutegravir and Lamivudine are medications used together to treat HIV. While they are generally safe, there are some potential risks and side effects to be aware of. 1. **Common Side Effects**: These can include headache, diarrhea, nausea, and trouble sleeping. These are usually mild and may go away as your body adjusts to the medication. 2. **Serious Side Effects**: Although rare, some people may experience more serious side effects such as liver problems, which can cause symptoms like yellowing of the skin or eyes, dark urine, or pain in the upper right part of the stomach. 3. **Allergic Reactions**: Some individuals might have an allergic reaction, which can be serious. Symptoms can include rash, itching, swelling, severe dizziness, or trouble breathing. 4. **Drug Interactions**: Dolutegravir and Lamivudine can interact with other medications, which might increase the risk of side effects or reduce the effectiveness of the treatment. It's important to inform your healthcare provider about all the medications you are taking. 5. **Pregnancy and Breastfeeding**: If you are pregnant or breastfeeding, consult your doctor as these medications can affect the baby. Always discuss any concerns or symptoms with your healthcare provider to ensure safe and effective use of these medications.
Are there harms and risks from taking combination of Lamivudine and Dolutegravir?
Common side effects of lamivudine and dolutegravir include headache, nausea, diarrhea, trouble sleeping, tiredness, and anxiety. Significant adverse effects can include hypersensitivity reactions, liver problems, and lactic acidosis. Patients should be aware of symptoms such as rash, fever, or jaundice, and seek medical attention if they occur. Regular monitoring by a healthcare provider is important to manage any potential side effects and ensure the medication is working effectively.
Can I take combination of Dolutegravir and Lamivudine with other prescription drugs?
Dolutegravir and Lamivudine are medications used to treat HIV. When taking these drugs, it's important to be aware of potential interactions with other prescription medications. According to the NHS, some drugs can affect how well Dolutegravir and Lamivudine work or increase the risk of side effects. For example, certain antacids or supplements containing calcium, magnesium, or iron can interfere with the absorption of Dolutegravir. It's recommended to take these at least two hours before or six hours after Dolutegravir. Additionally, the NLM advises that you should inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements, to avoid harmful interactions. Your doctor can help adjust dosages or suggest alternative treatments if necessary. Always consult with your healthcare provider before starting any new medication to ensure it's safe to use with Dolutegravir and Lamivudine.
Can I take combination of Lamivudine and Dolutegravir with other prescription drugs?
Significant prescription drug interactions with lamivudine and dolutegravir include dofetilide, which should not be taken with this combination due to the risk of serious side effects. Additionally, medications such as carbamazepine and rifampin can decrease dolutegravir levels, requiring dosage adjustments. Patients should inform their healthcare provider of all medications they are taking to manage potential interactions and ensure the effectiveness of their HIV treatment.
Can I take combination of Dolutegravir and Lamivudine if I am pregnant?
According to the NHS, Dolutegravir and Lamivudine are medications used to treat HIV. If you are pregnant, it is important to consult your healthcare provider before taking these medications. Dolutegravir has been associated with a small risk of birth defects if taken at the time of conception or in the early stages of pregnancy. Your doctor will weigh the benefits and risks to determine the best treatment plan for you and your baby. Always follow your healthcare provider's advice regarding medication use during pregnancy.
Can I take combination of Lamivudine and Dolutegravir if I am pregnant?
Lamivudine and dolutegravir can be used during pregnancy, but there are some considerations. Dolutegravir has been associated with a small risk of neural tube defects when taken at conception. However, studies have shown no significant increase in birth defects overall. Pregnant individuals should discuss the benefits and risks with their healthcare provider, and there is a pregnancy registry to monitor outcomes for those exposed to these medications during pregnancy.
Can I take combination of Dolutegravir and Lamivudine while breastfeeding?
According to the NHS, Dolutegravir and Lamivudine are medications used to treat HIV. When it comes to breastfeeding, the NHS advises that women with HIV should not breastfeed to prevent the risk of transmitting the virus to the baby. This is because even if the viral load is undetectable, there is still a small risk of transmission through breast milk. Therefore, it is generally recommended to avoid breastfeeding while taking these medications. Always consult with a healthcare provider for personalized advice.
Can I take combination of Lamivudine and Dolutegravir while breastfeeding?
Lamivudine and dolutegravir are present in human milk, and breastfeeding is generally not recommended for individuals with HIV-1 due to the risk of transmitting the virus to the infant. Additionally, there is a potential for adverse reactions in the breastfed infant, similar to those seen in adults. Healthcare providers typically advise against breastfeeding while on this medication to prevent HIV transmission and protect the infant's health.
Who should avoid taking combination of Dolutegravir and Lamivudine?
People who should avoid taking the combination of Dolutegravir and Lamivudine include those who have a known allergy to either of these medications. Additionally, individuals with severe liver problems should be cautious, as these drugs can affect liver function. Pregnant women or those planning to become pregnant should consult their healthcare provider, as Dolutegravir has been associated with a risk of birth defects. It's also important for people taking certain other medications that interact with Dolutegravir and Lamivudine to avoid this combination. Always consult a healthcare professional before starting or stopping any medication.
Who should avoid taking combination of Lamivudine and Dolutegravir?
Important warnings for lamivudine and dolutegravir include the risk of hypersensitivity reactions, liver problems, and lactic acidosis. Patients with a history of hepatitis B or C should be closely monitored, as discontinuation of lamivudine can lead to severe exacerbations of hepatitis B. The combination is contraindicated in patients taking dofetilide due to the risk of serious side effects. Patients should inform their healthcare provider of any allergies or medical conditions before starting treatment.
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