Dihydroergotamine
Orthostatic Hypotension , Xerostomia ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Ergotamine Derivative
Controlled Drug Substance
No
Summary
Dihydroergotamine is used to treat migraines, which are severe headaches that can cause intense pain, nausea, and sensitivity to light. It provides relief during acute migraine attacks but is not used for preventing future migraines.
Dihydroergotamine works by narrowing blood vessels in the brain, which helps reduce headache symptoms. This action is similar to turning down the volume on a loudspeaker to reduce noise, thereby alleviating migraine pain.
Dihydroergotamine is usually given as a nasal spray or injection. For the nasal spray, adults typically use one spray in each nostril at the start of a migraine, with a maximum of 4 sprays in 24 hours. Injections are dosed by a healthcare provider.
Common side effects of dihydroergotamine include nausea, dizziness, and fatigue, which means feeling very tired. These effects are usually mild but can be more severe in some cases. If you notice new or worsening symptoms, contact your doctor.
Dihydroergotamine can cause serious side effects like high blood pressure and heart problems. It is not recommended for people with uncontrolled hypertension, which is high blood pressure, or coronary artery disease, which affects blood flow to the heart.
Indications and Purpose
How does dihydroergotamine work?
Dihydroergotamine works by narrowing blood vessels in the brain, which helps reduce migraine symptoms. Think of it like turning down the volume on a loudspeaker to reduce noise. This action helps alleviate headache pain and other migraine symptoms.
Is dihydroergotamine effective?
Dihydroergotamine is effective for treating migraines, which are severe headaches. It works by narrowing blood vessels in the brain, reducing headache symptoms. Clinical studies support its effectiveness in providing relief from migraine attacks.
What is dihydroergotamine?
Dihydroergotamine is a medication used to treat migraines, which are severe headaches. It belongs to a class of drugs called ergot alkaloids, which work by narrowing blood vessels in the brain to reduce headache symptoms. It's used for acute migraine relief, not for prevention.
Directions for Use
For how long do I take dihydroergotamine?
Dihydroergotamine is used for short-term relief of acute migraine attacks, not for long-term use. Use it only as needed and as prescribed by your doctor. Prolonged use can lead to medication-overuse headaches.
How do I dispose of dihydroergotamine?
Dispose of dihydroergotamine by taking it to a drug take-back program or collection site at a pharmacy or hospital. If unavailable, mix it with undesirable substances like used coffee grounds, seal in a plastic bag, and throw it away. This prevents harm to people and the environment.
How do I take dihydroergotamine?
Dihydroergotamine is usually administered as a nasal spray or injection. Follow your doctor's instructions on how to use it. The nasal spray is often used at the first sign of a migraine, and you should not exceed the recommended dose. Do not crush or mix the medication. It's important to avoid certain foods and drinks, like alcohol, while using this medicine. If you miss a dose, follow your doctor's advice on what to do next.
How long does it take for dihydroergotamine to start working?
Dihydroergotamine starts working within 30 minutes to 2 hours after administration. The time it takes to achieve full relief can vary based on individual factors like the severity of the migraine and how quickly the medication is taken after symptoms begin.
How should I store dihydroergotamine?
Store dihydroergotamine at room temperature, away from moisture and light. Keep it in a tightly closed container. Avoid storing it in humid places like bathrooms. Always keep it out of reach of children to prevent accidental ingestion.
What is the usual dose of dihydroergotamine?
The usual dose of dihydroergotamine varies based on the form and individual needs. For the nasal spray, adults typically use one spray in each nostril at the onset of a migraine, with a maximum of 4 sprays in 24 hours. For injections, the dose is usually determined by a healthcare provider. Always follow your doctor's specific dosing instructions.
Warnings and Precautions
Can dihydroergotamine be taken safely while breastfeeding?
Dihydroergotamine is not recommended while breastfeeding. It may pass into breast milk and affect the infant. Limited data is available on its effects, so it's best to avoid using it. Consult your doctor for safer alternatives if you're breastfeeding.
Can dihydroergotamine be taken safely while pregnant?
Dihydroergotamine is not recommended during pregnancy. It can affect blood flow to the fetus, which may cause harm. Limited human data is available, so it's best to avoid using it. Consult your doctor for safer alternatives if you're pregnant or planning to become pregnant.
Can I take dihydroergotamine with other prescription drugs?
Dihydroergotamine can interact with certain medications, increasing the risk of adverse effects. Avoid using it with other ergotamines or triptans, which are migraine medications, as this can lead to serious side effects. Always inform your doctor about all medications you're taking.
Does dihydroergotamine have adverse effects?
Adverse effects are unwanted reactions to a medication. Dihydroergotamine can cause nausea, dizziness, and fatigue. These effects are usually mild but can be more severe in some cases. Serious side effects include high blood pressure and heart problems. If you notice any new or worsening symptoms, contact your doctor immediately.
Does dihydroergotamine have any safety warnings?
Yes, dihydroergotamine has important safety warnings. It can cause serious side effects like high blood pressure and heart problems. It's not recommended for people with certain conditions like uncontrolled hypertension or coronary artery disease. Not following these warnings can lead to severe health issues. Always discuss your medical history with your doctor before using this medication.
Is dihydroergotamine addictive?
Dihydroergotamine is not considered addictive. It doesn't cause cravings or withdrawal symptoms. However, overuse can lead to medication-overuse headaches, which are headaches caused by taking too much headache medication. To avoid this, use dihydroergotamine only as prescribed by your doctor.
Is dihydroergotamine safe for the elderly?
Elderly individuals may be more sensitive to the effects of dihydroergotamine, which can cause dizziness and high blood pressure. It's important to monitor for these side effects and consult a doctor for appropriate dosing and safety measures.
Is it safe to drink alcohol while taking dihydroergotamine?
It's best to avoid alcohol while taking dihydroergotamine. Alcohol can increase the risk of side effects like dizziness and nausea. It may also worsen migraine symptoms. If you choose to drink, limit your intake and monitor for any adverse effects.
Is it safe to exercise while taking dihydroergotamine?
You can exercise while taking dihydroergotamine, but be cautious. This medication can cause dizziness, which might affect your ability to exercise safely. Avoid strenuous activities if you feel dizzy. Stay hydrated and listen to your body during workouts.
Is it safe to stop dihydroergotamine?
Dihydroergotamine is used for acute migraine relief, not long-term use. Stopping it doesn't cause withdrawal symptoms, but stopping during a migraine might leave symptoms unmanaged. Always follow your doctor's advice on when to use or stop the medication.
What are the most common side effects of dihydroergotamine?
Side effects are unwanted reactions to a medication. Common side effects of dihydroergotamine include nausea, dizziness, and fatigue. These effects vary from person to person. If you experience new symptoms after starting dihydroergotamine, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking dihydroergotamine?
Dihydroergotamine should not be used by people with uncontrolled hypertension, coronary artery disease, or severe liver or kidney problems. These are absolute contraindications due to severe risks. Use with caution if you have other health conditions, and always consult your doctor.
