Diethylstilbestrol
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Drug Status
Government Approvals
UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
None
Controlled Drug Substance
No
Summary
Diethylstilbestrol is used to treat menopausal symptoms, which are changes women experience when their menstrual periods stop, and certain cancers like prostate cancer, which is a disease where cells in the prostate grow uncontrollably. However, its use has declined due to safety concerns.
Diethylstilbestrol works by mimicking estrogen, which is a hormone that regulates various body functions. It binds to estrogen receptors, which are proteins that respond to estrogen, influencing cell growth and function. This can help manage symptoms like hot flashes or slow the growth of certain cancers.
Diethylstilbestrol is usually taken orally, which means by mouth, in tablet form. The typical dose for adults ranges from 1 to 3 mg per day, divided into smaller doses. It's important to follow your doctor's instructions on how to take it.
Common side effects of diethylstilbestrol include nausea, which is feeling sick to your stomach, vomiting, which is throwing up, and abdominal pain, which is discomfort in the stomach area. These effects can vary from person to person.
Diethylstilbestrol has important safety warnings. It can increase the risk of certain cancers and reproductive issues, especially when used during pregnancy. It should not be used by pregnant women or those with hormone-sensitive cancers, which are cancers that grow in response to hormones.
Indications and Purpose
How does diethylstilbestrol work?
Diethylstilbestrol is a synthetic estrogen that works by mimicking the effects of natural estrogen in the body. Estrogen is a hormone that regulates various functions, including reproductive health. Diethylstilbestrol binds to estrogen receptors, influencing cell growth and function. This can help manage symptoms like hot flashes or slow the growth of certain cancers. However, due to its risks, its use is limited. Always consult your doctor to understand how this medication works for your specific condition.
Is diethylstilbestrol effective?
Diethylstilbestrol was once used to treat certain conditions like menopausal symptoms and prostate cancer. However, its use has declined due to safety concerns. While it was effective in its intended uses, the risks associated with its use, such as increased cancer risk, have led to it being largely discontinued. Always consult your doctor for current and safer treatment options for your condition.
What is diethylstilbestrol?
Diethylstilbestrol is a synthetic estrogen, which is a hormone that regulates various functions in the body. It was used to treat menopausal symptoms and certain cancers, like prostate cancer. However, due to safety concerns, its use has declined. Diethylstilbestrol works by mimicking the effects of natural estrogen in the body. It's important to discuss with your doctor if this medication is appropriate for your condition, considering its risks and benefits.
Directions for Use
For how long do I take diethylstilbestrol?
Diethylstilbestrol is usually prescribed for specific conditions and the duration of use depends on your treatment plan. It's important to follow your doctor's instructions regarding how long to take this medication. Do not stop taking it without consulting your healthcare provider, as this could affect your treatment outcome. Your doctor will guide you on the appropriate duration based on your health needs and response to the medication.
How do I dispose of diethylstilbestrol?
To dispose of diethylstilbestrol, take it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take diethylstilbestrol?
Take diethylstilbestrol exactly as your doctor prescribes. It's usually taken once or twice daily, with or without food. Do not crush or chew the tablets. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not double up on doses. Avoid alcohol while taking this medication, as it can increase certain risks. Always follow your doctor's specific instructions regarding diet and fluid intake while on diethylstilbestrol.
How long does it take for diethylstilbestrol to start working?
The time it takes for diethylstilbestrol to work depends on the condition being treated. Some effects, like relief from menopausal symptoms, may be noticed within a few days. For conditions like cancer, it may take longer to see significant changes. Your doctor will monitor your progress and adjust your treatment as needed. It's important to take diethylstilbestrol exactly as prescribed and communicate with your healthcare provider about any changes you experience.
How should I store diethylstilbestrol?
Store diethylstilbestrol at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Avoid storing it in humid places like bathrooms, where moisture in the air could affect how well the medication works. Always store diethylstilbestrol out of children's reach to prevent accidental swallowing. Remember to check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of diethylstilbestrol?
The usual dose of diethylstilbestrol varies based on the condition being treated. For adults, the starting dose is typically 1 to 3 mg per day, taken in divided doses. Your doctor may adjust the dose based on your response and specific health needs. It's important to follow your doctor's dosing instructions carefully. Diethylstilbestrol is not commonly used in children or the elderly, so special considerations may apply. Always consult your healthcare provider for personalized dosing information.
Warnings and Precautions
Can diethylstilbestrol be taken safely while breastfeeding?
Diethylstilbestrol is not recommended while breastfeeding. There is limited information on whether it passes into breast milk, but due to its potential risks, it's best to avoid it. If you're taking diethylstilbestrol and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely. Your doctor can help you make informed decisions about your treatment and breastfeeding.
Can diethylstilbestrol be taken safely while pregnant?
Diethylstilbestrol is not safe to use during pregnancy. It has been linked to serious health issues in children exposed to it in the womb, including an increased risk of certain cancers and reproductive problems. If you are pregnant or planning to become pregnant, talk with your doctor about safer alternatives. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take diethylstilbestrol with other prescription drugs?
Diethylstilbestrol can interact with other medications, increasing the risk of adverse effects or reducing its effectiveness. It's important to inform your doctor about all the medications you are taking, including over-the-counter drugs and supplements. Your doctor can help identify any potential interactions and adjust your treatment plan accordingly. Regular communication with your healthcare provider ensures that your treatment remains safe and effective.
Does diethylstilbestrol have adverse effects?
Yes, diethylstilbestrol can have adverse effects, which are unwanted reactions to a medication. Common adverse effects include nausea, vomiting, and abdominal pain. More serious effects can include an increased risk of certain cancers and reproductive issues. If you notice any new or worsening symptoms, contact your doctor immediately. They can help determine if these symptoms are related to diethylstilbestrol and recommend appropriate actions to take.
Does diethylstilbestrol have any safety warnings?
Yes, diethylstilbestrol has important safety warnings. It was found to increase the risk of certain cancers and reproductive issues, especially when used during pregnancy. This medication can cause serious side effects, so it's crucial to follow your doctor's instructions and attend regular check-ups. Not adhering to safety warnings can lead to severe health consequences. If you experience any unusual symptoms, contact your healthcare provider immediately.
Is diethylstilbestrol addictive?
Diethylstilbestrol is not considered addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. This medication works by affecting hormone levels in the body, but it doesn't impact brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, discuss them with your doctor. They can provide reassurance and guidance on managing your treatment safely.
Is diethylstilbestrol safe for the elderly?
The elderly may be more vulnerable to the safety risks of diethylstilbestrol due to age-related changes in metabolism and organ function. This medication can increase the risk of certain cancers and other health issues. It's important for elderly patients to have regular check-ups and communicate with their healthcare provider about any concerns. Your doctor can help determine if diethylstilbestrol is appropriate for you and monitor your health closely while on this medication.
Is it safe to drink alcohol while taking diethylstilbestrol?
It's best to avoid alcohol while taking diethylstilbestrol. Alcohol can increase the risk of certain side effects and may interfere with the medication's effectiveness. Drinking alcohol can also worsen any potential liver issues. If you do choose to drink occasionally, limit how much alcohol you consume and watch for any unusual symptoms. Talk with your doctor about alcohol use while taking diethylstilbestrol to get personalized advice based on your specific health situation.
Is it safe to exercise while taking diethylstilbestrol?
You can exercise while taking diethylstilbestrol, but keep a few things in mind. This medication can cause side effects like dizziness or fatigue, which might affect your exercise capacity. To exercise safely, listen to your body and avoid strenuous activities if you feel unwell. Drink plenty of water before, during, and after physical activity. If you notice any unusual symptoms during exercise, slow down or stop and rest. Consult your doctor if you have concerns about exercising while on this medication.
Is it safe to stop diethylstilbestrol?
Stopping diethylstilbestrol suddenly can have serious health consequences. If you're taking it for a specific condition, stopping might worsen your symptoms or lead to complications. Always talk with your doctor before stopping diethylstilbestrol. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
What are the most common side effects of diethylstilbestrol?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of diethylstilbestrol include nausea, vomiting, and abdominal pain. These effects vary from person to person. If you notice new symptoms after starting diethylstilbestrol, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication. They can help determine if the side effects are related to diethylstilbestrol and suggest ways to manage them.
Who should avoid taking diethylstilbestrol?
Diethylstilbestrol has several important contraindications. It should not be used by pregnant women due to the risk of birth defects and cancer in offspring. People with a history of hormone-sensitive cancers, such as breast or prostate cancer, should avoid it. If you have any allergies to its ingredients, do not take this medication. Always consult your doctor to ensure diethylstilbestrol is safe for you, considering your medical history and current health conditions.
