Dextromethorphan + Promethazine
Find more information about this combination medication at the webpages for Promethazine and Dextromethorphan
Allergic Conjunctivitis, Perennial Allergic Rhinitis ... show more
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Advisory
- This medicine contains a combination of 2 drugs Dextromethorphan and Promethazine.
- Each of these drugs treats a different disease or symptom.
- Treating different diseases with different medicines allows doctors to adjust the dose of each medicine separately. This prevents overmedication or undermedication.
- Most doctors advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Phenothiazine and Sigma-1 Agonist and Uncompetitive N-methyl-D-aspartate Receptor Antagonist
Controlled Drug Substance
NO
Summary
Dextromethorphan and Promethazine are used to relieve symptoms of colds, allergies, and coughs. Dextromethorphan suppresses coughs, while Promethazine reduces allergy symptoms like runny nose, sneezing, and itching. However, these medications do not treat the underlying cause of these symptoms.
Dextromethorphan works by decreasing activity in the brain area that triggers coughing. Promethazine blocks histamine action in the body, reducing allergy symptoms. Together, they provide comprehensive relief from cough and allergy symptoms.
Adults typically take 10 to 20 mg of Dextromethorphan every 4 to 6 hours, not exceeding 120 mg in 24 hours. Promethazine is usually dosed at 25 mg before bedtime or 12.5 mg before meals and at bedtime. When combined, the syrup form is often dosed at 5 mL every 4 to 6 hours, not exceeding 30 mL in 24 hours.
Common side effects include drowsiness, dizziness, and nausea. Promethazine may cause dry mouth, blurred vision, and constipation, while Dextromethorphan can lead to lightheadedness and stomach pain. More serious effects include respiratory depression and allergic reactions like rash or swelling.
Promethazine should not be used in children under 2 years due to the risk of fatal respiratory depression. Dextromethorphan should not be used with monoamine oxidase inhibitors (MAOIs) due to the risk of serotonin syndrome, a potentially life-threatening condition. Both medications can cause drowsiness, so caution is advised when driving or operating machinery.
Indications and Purpose
How does combination of Dextromethorphan and Promethazine work?
The combination of Dextromethorphan and Promethazine works by addressing symptoms of cough and allergies. Dextromethorphan is a cough suppressant that affects the signals in the brain that trigger the cough reflex, helping to reduce the urge to cough. Promethazine is an antihistamine that relieves allergy symptoms such as runny nose, sneezing, and itching by blocking the action of histamine, a substance in the body that causes allergic symptoms. Together, they help manage symptoms of cold, allergies, or other respiratory illnesses.
How does combination of Promethazine and Dextromethorphan work?
Promethazine and dextromethorphan work by targeting different pathways in the body to alleviate symptoms. Dextromethorphan acts on the brain to suppress the cough reflex, providing relief from persistent coughing. Promethazine blocks histamine receptors, reducing symptoms of allergies such as runny nose and itching. Together, they provide a comprehensive approach to managing symptoms of colds and allergies, though they do not address the underlying cause of these symptoms.
How effective is combination of Dextromethorphan and Promethazine?
The combination of Dextromethorphan and Promethazine is used to treat symptoms caused by the common cold, allergies, or other breathing illnesses. Dextromethorphan is a cough suppressant that works by affecting the signals in the brain that trigger cough reflex. Promethazine is an antihistamine that relieves allergy symptoms such as runny nose and sneezing. Together, they can be effective in reducing cough and other related symptoms. However, it's important to use this combination only as directed by a healthcare professional, as it can cause side effects and may not be suitable for everyone. For instance, it can cause drowsiness, so activities requiring alertness should be avoided. Always consult with a healthcare provider to ensure it's appropriate for your specific condition.
How effective is combination of Promethazine and Dextromethorphan?
The effectiveness of promethazine and dextromethorphan is supported by their pharmacological actions. Dextromethorphan is a well-known antitussive that effectively suppresses the cough reflex, while promethazine, an antihistamine, reduces allergy symptoms by blocking histamine receptors. Clinical use and patient reports confirm their efficacy in providing symptomatic relief from coughs and allergies. Together, they offer a dual approach to managing symptoms, though they do not address the underlying causes of these conditions.
Directions for Use
What is the usual dose of combination of Dextromethorphan and Promethazine?
The usual dose of the combination of Dextromethorphan and Promethazine can vary based on the specific formulation and the patient's age. For adults and children over 12 years, a common dose might be 5 ml to 10 ml every 4 to 6 hours, not exceeding 30 ml in 24 hours. For children aged 6 to 12 years, the dose is typically lower, around 2.5 ml to 5 ml every 4 to 6 hours, with a maximum of 20 ml in 24 hours. It's important to follow the specific dosing instructions provided by a healthcare professional or the medication's packaging. Dextromethorphan is a cough suppressant, while Promethazine is an antihistamine that can help with allergy symptoms and nausea.
What is the usual dose of combination of Promethazine and Dextromethorphan?
For adults, the typical dose of dextromethorphan is 10 to 20 mg every 4 to 6 hours, not exceeding 120 mg in 24 hours. Promethazine is usually dosed at 25 mg before bedtime or 12.5 mg before meals and at bedtime, depending on the condition being treated. When combined, the syrup form of promethazine with dextromethorphan is often dosed at 5 mL every 4 to 6 hours, not exceeding 30 mL in 24 hours. It's important to follow the specific dosing instructions provided by a healthcare provider or on the medication label.
How does one take combination of Dextromethorphan and Promethazine?
Dextromethorphan and Promethazine are medications often used together to relieve symptoms of cough and cold. Dextromethorphan is a cough suppressant, which means it helps reduce the urge to cough. Promethazine is an antihistamine, which helps with allergy symptoms and can also make you feel drowsy, which might help you rest. When taking this combination, it's important to follow the dosage instructions provided by your healthcare provider or those on the medication packaging. Typically, this medication is taken by mouth, with or without food. It's crucial not to exceed the recommended dose, as doing so can increase the risk of side effects. Common side effects may include drowsiness, dizziness, or dry mouth. If you experience severe side effects or signs of an allergic reaction, such as difficulty breathing or swelling, seek medical attention immediately. Always consult with a healthcare professional before starting any new medication to ensure it's appropriate for your specific health needs.
How does one take combination of Promethazine and Dextromethorphan?
Promethazine and dextromethorphan can be taken with or without food, but taking them with food may help reduce stomach upset. It's important to follow the dosing instructions on the label or as prescribed by a healthcare provider. Avoid consuming alcohol while taking this medication, as it can increase drowsiness and other side effects. Additionally, users should be cautious about taking other medications that may contain similar ingredients to avoid overdose.
For how long is combination of Dextromethorphan and Promethazine taken?
The combination of Dextromethorphan and Promethazine is typically taken for a short period, usually not exceeding 7 days. This is because it is used to relieve symptoms of cough and cold, which are generally temporary conditions. It's important to follow the dosage and duration instructions provided by a healthcare professional or as indicated on the medication packaging. If symptoms persist beyond this period, it is advisable to consult a healthcare provider for further evaluation.
For how long is combination of Promethazine and Dextromethorphan taken?
Promethazine and dextromethorphan are typically used for short-term relief of symptoms associated with colds, allergies, and coughs. The duration of use is generally limited to a few days, often not exceeding 7 days, unless directed otherwise by a healthcare provider. This is because these medications are intended to alleviate symptoms rather than treat the underlying cause, and prolonged use can lead to side effects or mask more serious conditions.
How long does it take for combination of Dextromethorphan and Promethazine to work?
The combination of Dextromethorphan and Promethazine typically begins to work within 30 minutes to 1 hour after taking it. Dextromethorphan is a cough suppressant, and Promethazine is an antihistamine that helps with allergy symptoms and can also have a sedative effect. Together, they help reduce coughing and relieve allergy symptoms. However, the exact time can vary depending on individual factors such as metabolism and overall health.
How long does it take for combination of Promethazine and Dextromethorphan to work?
Promethazine and dextromethorphan work relatively quickly after administration. Dextromethorphan, an antitussive, typically begins to relieve cough within 15 to 30 minutes after oral intake. Promethazine, an antihistamine, starts to show effects within 20 minutes of oral administration. Both medications are absorbed from the gastrointestinal tract, allowing them to act swiftly. The combination of these two medicines provides relief from cough and allergy symptoms, with effects generally lasting between 4 to 6 hours, although promethazine's effects may persist up to 12 hours.
Warnings and Precautions
Are there harms and risks from taking combination of Dextromethorphan and Promethazine?
Yes, there are potential harms and risks from taking a combination of Dextromethorphan and Promethazine. Dextromethorphan is a cough suppressant, and Promethazine is an antihistamine used to treat allergy symptoms. When taken together, they can cause increased drowsiness, dizziness, and confusion. This combination can also lead to serious side effects such as respiratory depression, which is a condition where breathing becomes inadequate. This is particularly risky for children, the elderly, and individuals with certain health conditions. It's important to use these medications only as prescribed by a healthcare professional and to be aware of these potential risks. For more detailed information, you can refer to trusted sources like the NHS or NLM.
Are there harms and risks from taking combination of Promethazine and Dextromethorphan?
Common side effects of promethazine and dextromethorphan include drowsiness, dizziness, and nausea. Promethazine may also cause dry mouth, blurred vision, and constipation, while dextromethorphan can lead to lightheadedness and stomach pain. Significant adverse effects include respiratory depression, especially in children, and allergic reactions such as rash or swelling. Both medications can cause nervous system effects, so caution is advised when performing tasks that require alertness.
Can I take combination of Dextromethorphan and Promethazine with other prescription drugs?
Dextromethorphan and Promethazine are medications that can interact with other prescription drugs, potentially causing side effects or reducing effectiveness. Dextromethorphan is a cough suppressant, while Promethazine is an antihistamine used to treat allergy symptoms and nausea. According to the NHS, it's important to consult with a healthcare professional before combining these medications with other drugs, especially those that affect the central nervous system, such as antidepressants, sedatives, or pain relievers. These combinations can increase the risk of side effects like drowsiness, dizziness, or difficulty breathing. The NLM also advises checking with a doctor or pharmacist to ensure that there are no harmful interactions with your current medications. Always provide a full list of your medications to your healthcare provider to receive the best advice. For more detailed information, you can visit trusted sources like the NHS or NLM websites.
Can I take combination of Promethazine and Dextromethorphan with other prescription drugs?
Promethazine and dextromethorphan can interact with several prescription drugs. Dextromethorphan should not be used with monoamine oxidase inhibitors (MAOIs) due to the risk of serotonin syndrome. Promethazine can enhance the sedative effects of CNS depressants like alcohol, sedatives, and narcotics. Both medications should be used cautiously with other drugs that affect the central nervous system to avoid excessive sedation or respiratory depression.
Can I take combination of Dextromethorphan and Promethazine if I am pregnant?
It is important to consult with a healthcare professional before taking any medication during pregnancy, including the combination of Dextromethorphan and Promethazine. According to the NHS, some medications can be harmful to the developing baby, and a doctor can help determine if the benefits outweigh the risks in your specific situation. Dextromethorphan is a cough suppressant, and Promethazine is an antihistamine used to treat allergies and nausea, but their safety during pregnancy should be evaluated by a healthcare provider.
Can I take combination of Promethazine and Dextromethorphan if I am pregnant?
The safety of promethazine and dextromethorphan during pregnancy is not fully established. Promethazine is categorized as pregnancy category C, indicating that risk to the fetus cannot be ruled out. Dextromethorphan's safety in pregnancy is also uncertain, and it should be used only if clearly needed. Pregnant women should consult their healthcare provider to evaluate the potential benefits and risks before using these medications.
Can I take combination of Dextromethorphan and Promethazine while breastfeeding?
According to the NHS, it is generally advised to avoid taking Dextromethorphan and Promethazine while breastfeeding unless specifically recommended by a healthcare professional. Dextromethorphan is a cough suppressant, and Promethazine is an antihistamine used to treat allergies and nausea. Both can pass into breast milk and may affect a nursing baby. It's important to consult with a healthcare provider to weigh the potential risks and benefits before using these medications while breastfeeding.
Can I take combination of Promethazine and Dextromethorphan while breastfeeding?
The safety of promethazine and dextromethorphan during lactation is not well-established. Promethazine is known to be excreted in breast milk and may cause irritability or sedation in nursing infants. There is no specific information on dextromethorphan's excretion in breast milk, but caution is advised. Nursing mothers should consult their healthcare provider before using these medications to weigh the potential benefits against the risks to the infant.
Who should avoid taking combination of Dextromethorphan and Promethazine?
People who should avoid taking the combination of Dextromethorphan and Promethazine include: 1. **Children under 2 years old**: This combination can cause serious breathing problems in young children. 2. **Individuals with breathing problems**: People with conditions like asthma or chronic obstructive pulmonary disease (COPD) should avoid this combination as it can worsen breathing difficulties. 3. **Those with certain medical conditions**: People with a history of seizures, liver disease, or heart problems should consult a doctor before using this combination. 4. **Pregnant or breastfeeding women**: They should seek medical advice before taking these medications as they can affect the baby. 5. **People taking certain medications**: Those on medications that cause drowsiness or have similar effects should avoid this combination to prevent excessive sedation or other side effects. 6. **Individuals with allergies to the ingredients**: Anyone with known allergies to Dextromethorphan, Promethazine, or similar drugs should not take this combination. Always consult a healthcare professional before starting any new medication to ensure it is safe based on your health history and current medications.
Who should avoid taking combination of Promethazine and Dextromethorphan?
Promethazine and dextromethorphan have several important warnings. Promethazine should not be used in children under 2 years due to the risk of fatal respiratory depression. Dextromethorphan should not be used with MAOIs. Both medications can cause drowsiness and should be used with caution when driving or operating machinery. They should be avoided in individuals with respiratory issues like asthma or COPD, and caution is advised in those with liver disease or a history of drug abuse.
