Deutetrabenazine
Chorea, Tardive Dyskinesia
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
deutetrabenazine
Summary
Deutetrabenazine is used to treat chorea, which are involuntary movements, associated with Huntington's disease. It helps reduce these movements, improving the quality of life for patients. It may also be used for other conditions involving involuntary movements as determined by a doctor.
Deutetrabenazine works by inhibiting a protein called vesicular monoamine transporter 2 (VMAT2), which is involved in the storage and release of certain brain chemicals. By blocking VMAT2, it reduces the activity of these chemicals, helping to control involuntary movements.
The usual starting dose for adults is 6 mg taken twice daily. The dose may be adjusted by a doctor based on individual response and needs, with a maximum recommended dose of 48 mg per day. It is taken orally, with or without food.
Common side effects include drowsiness, fatigue, and insomnia, which is difficulty sleeping. These effects are usually mild to moderate. If you experience severe or persistent symptoms, it's important to talk to your doctor.
Deutetrabenazine can increase the risk of depression and suicidal thoughts, especially in those with a history of depression. It is contraindicated in people with severe liver problems. Always consult your doctor about any concerns before starting this medication.
Indications and Purpose
How does Deutetrabenazine work?
Deutetrabenazine works by inhibiting a protein called vesicular monoamine transporter 2 (VMAT2), which is involved in the storage and release of certain chemicals in the brain. By blocking VMAT2, Deutetrabenazine reduces the activity of these chemicals, helping to control involuntary movements. Think of it like turning down the volume on a radio to reduce noise. This action helps manage symptoms of chorea in Huntington's disease, improving movement control and quality of life.
Is Deutetrabenazine effective?
Deutetrabenazine is effective for treating chorea, which is involuntary movements, associated with Huntington's disease. Clinical studies show it significantly reduces chorea symptoms, improving patients' quality of life. The medication works by decreasing the activity of certain chemicals in the brain that are involved in movement control. Evidence supports its effectiveness for this indication, making it a valuable treatment option for managing chorea in Huntington's disease. Always follow your doctor's instructions to achieve the best results.
What is Deutetrabenazine?
Deutetrabenazine is a medication used to treat chorea, which is involuntary movements, associated with Huntington's disease. It belongs to a class of drugs called vesicular monoamine transporter 2 (VMAT2) inhibitors. Deutetrabenazine works by reducing the activity of certain chemicals in the brain that are involved in movement control. This helps decrease the involuntary movements that occur in Huntington's disease. It's also used for other conditions involving involuntary movements, as determined by your doctor.
Directions for Use
For how long do I take Deutetrabenazine?
Deutetrabenazine is usually a long-term medication for managing chronic conditions like Huntington's disease. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your conditions to worsen. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Deutetrabenazine treatment.
How do I dispose of Deutetrabenazine?
Dispose of Deutetrabenazine properly to avoid harm. If possible, take unused medicine to a drug take-back program or collection site at a pharmacy or hospital. If no take-back program is available, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away. This helps prevent accidental ingestion or environmental harm.
How do I take Deutetrabenazine?
Take Deutetrabenazine exactly as your doctor prescribes. Usually, you start with a low dose, which can be adjusted based on your response. It's typically taken twice daily, with or without food. Swallow the tablets whole; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose and continue your regular schedule. Avoid taking two doses at once. Follow any dietary or beverage restrictions your doctor advises while on this medication.
How long does it take for Deutetrabenazine to start working?
Deutetrabenazine may start to work within a few days, but it can take several weeks to achieve its full therapeutic effect. The time it takes to notice improvements can vary based on individual factors like your condition and response to the medication. Regular check-ups with your doctor are important to monitor your progress. They can help determine if the medication is working effectively and make any necessary adjustments to your treatment plan.
How should I store Deutetrabenazine?
Store Deutetrabenazine at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Avoid storing it in humid places like bathrooms, where moisture can affect the medication's effectiveness. Always keep Deutetrabenazine out of children's reach to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication. Follow your pharmacist's instructions for safe storage.
What is the usual dose of Deutetrabenazine?
The usual starting dose of Deutetrabenazine for adults is 6 mg twice daily. Your doctor may adjust the dose based on your response and needs. The maximum recommended dose is 48 mg per day. Dose adjustments may be necessary for special populations, such as the elderly or those with liver problems. Always follow your doctor's specific dosing instructions for your health needs. Do not change your dose without consulting your healthcare provider.
Warnings and Precautions
Can Deutetrabenazine be taken safely while breastfeeding?
The safety of Deutetrabenazine while breastfeeding is not well-established. It's unclear if the medication passes into breast milk or affects the breastfed infant. Due to limited information, it's best to consult your doctor before using Deutetrabenazine while breastfeeding. They can help weigh the potential risks and benefits and suggest safer alternatives if necessary. Always discuss your treatment options with your healthcare provider to ensure the safety of both you and your baby.
Can Deutetrabenazine be taken safely while pregnant?
The safety of Deutetrabenazine during pregnancy is not well-established. Limited evidence makes it difficult to provide definitive advice. Animal studies suggest potential risks, but human data is lacking. If you're pregnant or planning to become pregnant, discuss the risks and benefits with your doctor. They can help determine the safest treatment plan for you and your baby. Always consult your healthcare provider before starting or continuing Deutetrabenazine during pregnancy.
Can I take Deutetrabenazine with other prescription drugs?
Deutetrabenazine has some concerning drug interactions. It should not be used with monoamine oxidase inhibitors (MAOIs), which are a type of antidepressant, as this can increase the risk of serious side effects. Caution is needed when used with other medications that affect serotonin levels, as this can lead to serotonin syndrome, which is a potentially life-threatening condition. Always inform your doctor about all medications you take to prevent harmful interactions. Your doctor can help manage your treatment safely.
Does Deutetrabenazine have adverse effects?
Adverse effects are unwanted reactions to a medication. Deutetrabenazine can cause adverse effects like drowsiness, fatigue, and insomnia, which are common. Serious adverse effects include depression and suicidal thoughts, which require immediate medical attention. If you notice any new or worsening symptoms, contact your doctor. They can help determine if these symptoms are related to Deutetrabenazine and suggest appropriate actions. Always report any adverse effects to your healthcare provider to ensure safe and effective treatment.
Does Deutetrabenazine have any safety warnings?
Yes, Deutetrabenazine has important safety warnings. It can increase the risk of depression and suicidal thoughts, especially in people with a history of depression. Not adhering to these warnings can lead to serious mental health issues. If you experience mood changes, depression, or suicidal thoughts, contact your doctor immediately. Regular monitoring by your healthcare provider is essential to manage these risks effectively. Always discuss any concerns with your doctor to ensure safe use of Deutetrabenazine.
Is Deutetrabenazine addictive?
Deutetrabenazine is not considered addictive or habit-forming. It does not cause physical or psychological dependence. The medication works by affecting certain chemicals in the brain, but it doesn't alter brain chemistry in a way that leads to addiction. You won't experience cravings or withdrawal symptoms when stopping Deutetrabenazine. If you have concerns about medication dependence, discuss them with your doctor. They can provide reassurance and guidance on managing your treatment safely.
Is Deutetrabenazine safe for the elderly?
Elderly individuals may be more vulnerable to the side effects of Deutetrabenazine, such as drowsiness and dizziness. These effects can increase the risk of falls and injuries. The medication is generally safe for the elderly, but careful monitoring is essential. Your doctor may start with a lower dose and adjust it based on your response. Regular check-ups are important to ensure the medication is working effectively and safely. Always discuss any concerns with your healthcare provider.
Is it safe to drink alcohol while taking Deutetrabenazine?
It's best to avoid alcohol while taking Deutetrabenazine. Alcohol can increase the risk of side effects like drowsiness and dizziness, which can impair your ability to function safely. Drinking alcohol may also worsen any mood changes or depression associated with Deutetrabenazine. If you choose to drink occasionally, limit your alcohol intake and watch for any warning signs. Talk with your doctor about alcohol use while taking Deutetrabenazine to get personalized advice based on your health situation.
Is it safe to exercise while taking Deutetrabenazine?
You can exercise while taking Deutetrabenazine, but be cautious. This medication can cause drowsiness or dizziness, which might affect your ability to exercise safely. Start with light activities and see how your body responds. If you feel dizzy or unusually tired, stop exercising and rest. Drink plenty of water to stay hydrated. Most people can maintain their regular exercise routine while taking Deutetrabenazine, but check with your doctor if you have concerns about your specific situation.
Is it safe to stop Deutetrabenazine?
It's not safe to stop Deutetrabenazine suddenly without consulting your doctor. This medication is often used long-term for chronic conditions like Huntington's disease. Stopping it abruptly can worsen symptoms or cause withdrawal effects. Always talk with your doctor before stopping Deutetrabenazine. They might suggest gradually reducing your dose to prevent complications. Your doctor will help you make any medication changes safely to protect your health.
What are the most common side effects of Deutetrabenazine?
Side effects are unwanted reactions to a medication. Common side effects of Deutetrabenazine include drowsiness, fatigue, and insomnia, affecting more than 10% of users. These side effects are usually mild to moderate. If you experience new symptoms after starting Deutetrabenazine, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication. They can help determine if the side effects are related to Deutetrabenazine and suggest ways to manage them.
Who should avoid taking Deutetrabenazine?
Deutetrabenazine has important contraindications. Do not use it if you have untreated or inadequately treated depression, as it can worsen this condition. It's also contraindicated in people with hepatic impairment, which is severe liver problems, because the drug is processed by the liver. Caution is needed if you have a history of depression or suicidal thoughts. Always consult your doctor about these concerns before starting Deutetrabenazine to ensure it's safe for you.
