Desvenlafaxine
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Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Serotonin and Norepinephrine Reuptake Inhibitor
Controlled Drug Substance
No
Desvenlafaxine
Summary
Desvenlafaxine is primarily used to treat major depressive disorder and generalized anxiety disorder. It can also be used to manage symptoms of neuropathic pain, particularly in diabetic peripheral neuropathy, and in some cases for stress urinary incontinence.
Desvenlafaxine works by increasing the levels of serotonin and norepinephrine in the brain. These are neurotransmitters that help regulate mood and pain. By inhibiting their reuptake into nerve cells, it helps alleviate symptoms of depression and anxiety.
For adults, the usual starting dose of Desvenlafaxine is 50 mg once daily taken orally, with or without food. The dose may be increased based on individual response and tolerability, up to a maximum of 400 mg daily. It's important to take it at the same time each day.
Common side effects of Desvenlafaxine include nausea, dry mouth, dizziness, insomnia, constipation, and sweating. Serious adverse effects may include increased blood pressure, agitation, hallucinations, suicidal thoughts, and withdrawal symptoms upon abrupt discontinuation.
Desvenlafaxine should be used with caution in individuals with a history of high blood pressure, heart problems, or liver/kidney issues. It is contraindicated in those with uncontrolled glaucoma or a history of serotonin syndrome. Caution is also needed for those with a history of depression, bipolar disorder, or suicidal thoughts.
Indications and Purpose
How does Desvenlafaxine work?
Desvenlafaxine works by affecting neurotransmitters in the brain, which are chemicals that help regulate mood. It belongs to a class of medications called serotonin-norepinephrine reuptake inhibitors (SNRIs). These medications increase the levels of serotonin and norepinephrine, which are neurotransmitters that influence mood and emotions. Think of it like adjusting the volume on a radio to get a clearer sound. By balancing these chemicals, Desvenlafaxine helps improve mood and reduce symptoms of depression.
Is Desvenlafaxine effective?
Yes, Desvenlafaxine is effective for treating major depressive disorder, which is a condition characterized by persistent sadness and loss of interest in activities. Clinical studies show that Desvenlafaxine can significantly improve symptoms of depression, leading to better mood and increased energy levels. It works by affecting neurotransmitters in the brain, which are chemicals that help regulate mood. Your doctor will monitor your progress to ensure the medication is working effectively for you.
What is Desvenlafaxine?
Desvenlafaxine is a medication used to treat major depressive disorder, which is a condition characterized by persistent sadness and loss of interest in activities. It belongs to a class of drugs called serotonin-norepinephrine reuptake inhibitors (SNRIs), which work by increasing the levels of serotonin and norepinephrine in the brain. These neurotransmitters help regulate mood and emotions. Desvenlafaxine is primarily used for depression but may also be prescribed for other conditions as determined by your doctor.
Directions for Use
For how long do I take Desvenlafaxine?
Desvenlafaxine is usually taken long-term for managing chronic conditions like major depressive disorder. The duration of use depends on your response to the medication and your doctor's recommendations. It's important to follow your doctor's advice and not stop taking Desvenlafaxine without consulting them. Stopping suddenly can lead to withdrawal symptoms. Your doctor will guide you on how long to continue the medication based on your health needs and progress.
How do I dispose of Desvenlafaxine?
To dispose of Desvenlafaxine, take it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away. Always keep medications out of reach of children and pets.
How do I take Desvenlafaxine?
Take Desvenlafaxine once daily, usually in the morning, with or without food. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. There are no specific dietary restrictions, but avoid alcohol as it can increase side effects. Always follow your doctor's instructions regarding dosage and any specific advice they provide.
How long does it take for Desvenlafaxine to start working?
Desvenlafaxine may start to improve symptoms of depression within one to two weeks, but it can take several weeks to achieve its full therapeutic effect. Individual factors like age, overall health, and other medications can affect how quickly you notice improvements. It's important to take Desvenlafaxine exactly as prescribed and continue taking it even if you don't notice immediate changes. Regular check-ups with your doctor can help monitor your progress and adjust your treatment if needed.
How should I store Desvenlafaxine?
Store Desvenlafaxine at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Avoid storing it in humid places like bathrooms, as moisture can affect the medication's effectiveness. Desvenlafaxine does not require refrigeration. Always keep it out of reach of children and pets to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Desvenlafaxine?
The usual starting dose of Desvenlafaxine for adults is 50 mg once daily, with or without food. Your doctor may adjust the dose based on your response and needs. The maximum recommended dose is 100 mg per day. Desvenlafaxine is not typically used in children. Elderly patients may require careful monitoring due to potential side effects. Always follow your doctor's specific dosing instructions for your health needs.
Warnings and Precautions
Can Desvenlafaxine be taken safely while breastfeeding?
The safety of Desvenlafaxine while breastfeeding is not well-established. It's unclear if the medication passes into breast milk or affects the breastfed infant. Some studies suggest potential risks, so it's important to weigh the benefits and risks. If you're breastfeeding or planning to breastfeed, talk with your doctor about the safest treatment options. They can help create a plan that ensures the well-being of both you and your baby.
Can Desvenlafaxine be taken safely while pregnant?
The safety of Desvenlafaxine during pregnancy is not well-established. Limited evidence makes it difficult to provide definitive advice. Some studies suggest potential risks to the fetus, such as complications during delivery. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options. They can help create a plan that balances the benefits and risks of using Desvenlafaxine during pregnancy.
Can I take Desvenlafaxine with other prescription drugs?
Desvenlafaxine can interact with other medications, increasing the risk of side effects or reducing effectiveness. Major interactions include monoamine oxidase inhibitors (MAOIs), which can lead to serotonin syndrome, a serious condition caused by too much serotonin in the brain. Other interactions include blood thinners, which may increase bleeding risk, and other antidepressants, which can enhance side effects. Always inform your doctor about all medications you take to avoid interactions and ensure safe treatment.
Does Desvenlafaxine have adverse effects?
Yes, Desvenlafaxine can have adverse effects, which are unwanted reactions to a medication. Common adverse effects include nausea, dizziness, and dry mouth. These occur in more than 10% of users. Serious side effects, though rare, include serotonin syndrome and increased blood pressure. If you experience any severe or unusual symptoms, contact your doctor immediately. They can help determine if the symptoms are related to Desvenlafaxine and advise on the best course of action.
Does Desvenlafaxine have any safety warnings?
Yes, Desvenlafaxine has important safety warnings. It can increase the risk of serotonin syndrome, which is a serious condition caused by too much serotonin in the brain. Symptoms include confusion, rapid heart rate, and high blood pressure. Desvenlafaxine can also increase blood pressure, so regular monitoring is important. Not adhering to these warnings can lead to severe health issues. Always follow your doctor's advice and report any unusual symptoms immediately.
Is Desvenlafaxine addictive?
Desvenlafaxine is not considered addictive or habit-forming. It does not cause cravings or withdrawal symptoms typical of addictive substances. However, stopping Desvenlafaxine suddenly can lead to withdrawal symptoms like dizziness, irritability, or flu-like symptoms. To prevent these, your doctor may gradually reduce your dose when it's time to stop. Always follow your doctor's guidance when discontinuing the medication.
Is Desvenlafaxine safe for the elderly?
Desvenlafaxine can be used by the elderly, but they may be more vulnerable to side effects like dizziness, which can increase the risk of falls. The elderly may also have other health conditions or take multiple medications, which can affect how Desvenlafaxine works. Regular monitoring by a doctor is important to ensure safety and effectiveness. Dose adjustments may be necessary based on individual health needs. Always consult a doctor before starting or adjusting Desvenlafaxine.
Is it safe to drink alcohol while taking Desvenlafaxine?
It's best to avoid alcohol while taking Desvenlafaxine. Alcohol can increase the risk of side effects like dizziness and drowsiness, which can impair your ability to function safely. It may also worsen depression symptoms. If you choose to drink occasionally, limit your alcohol intake and be aware of how it affects you. Talk with your doctor about alcohol use while taking Desvenlafaxine to get personalized advice based on your health situation.
Is it safe to exercise while taking Desvenlafaxine?
Yes, it's generally safe to exercise while taking Desvenlafaxine. However, be aware that the medication can cause dizziness or fatigue, which might affect your exercise capacity. Start with light to moderate activities and listen to your body. If you feel dizzy or unusually tired, take a break and rest. Staying hydrated and maintaining a balanced diet can help support your energy levels. Consult your doctor if you have concerns about exercising while on Desvenlafaxine.
Is it safe to stop Desvenlafaxine?
It's not safe to stop Desvenlafaxine suddenly. Doing so can lead to withdrawal symptoms like dizziness, irritability, or flu-like symptoms. Desvenlafaxine is usually used for long-term treatment of chronic conditions like depression. If you need to stop taking it, your doctor will likely suggest gradually reducing your dose to minimize withdrawal effects. Always talk with your doctor before stopping Desvenlafaxine to ensure a safe and effective transition.
What are the most common side effects of Desvenlafaxine?
Common side effects of Desvenlafaxine include nausea, dizziness, dry mouth, and sweating. These side effects are unwanted reactions that can happen when taking a medication. They occur in more than 10% of users. If you notice new symptoms after starting Desvenlafaxine, they might be temporary or unrelated to the medication. It's important to talk with your doctor before stopping any medication. They can help determine if the side effects are related to Desvenlafaxine and suggest ways to manage them.
Who should avoid taking Desvenlafaxine?
Desvenlafaxine should not be used if you have an allergy to it or its ingredients. This is an absolute contraindication, meaning the drug must not be used due to severe risks. It should also be avoided if you are taking or have recently taken monoamine oxidase inhibitors (MAOIs), which are a type of antidepressant, due to the risk of serotonin syndrome. Always consult your doctor about any concerns or conditions before starting Desvenlafaxine.
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