Desipramine
Depressive Disorder, Pain ... show more
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Tricyclic Antidepressant
Controlled Drug Substance
No
desipramine
Summary
Desipramine is used to treat depression, which is a mood disorder causing persistent sadness, and certain types of nerve pain, which refers to discomfort caused by nerve damage.
Desipramine works by affecting neurotransmitters, which are chemicals in the brain that influence mood and pain perception, helping to improve mood and reduce pain.
The usual starting dose for adults is 25 to 50 mg per day, taken once or divided into smaller doses. For elderly patients, the starting dose is usually 10 to 25 mg per day.
Common side effects include dry mouth, which is a lack of saliva, constipation, which is difficulty in bowel movements, and dizziness, which is a sensation of spinning.
Desipramine can increase the risk of suicidal thoughts, especially in young people, and may cause heart problems, which are issues with heart function. It should not be used if you have severe heart problems.
Indications and Purpose
How does Desipramine work?
Desipramine works by affecting neurotransmitters, which are chemicals in the brain that influence mood and pain perception. It belongs to a class of drugs called tricyclic antidepressants. Think of neurotransmitters as messengers that help brain cells communicate. Desipramine helps balance these messengers, improving mood and reducing pain. This makes it effective for treating depression and certain types of nerve pain. The medication's effects may take several weeks to become noticeable.
Is Desipramine effective?
Yes, Desipramine is effective for treating depression and certain types of nerve pain. It works by affecting chemicals in the brain that influence mood and pain perception. Clinical studies show that Desipramine can significantly improve symptoms of depression and reduce nerve pain. However, individual responses can vary. It's important to follow your doctor's instructions and give the medication time to work, as it may take several weeks to see full benefits.
What is Desipramine?
Desipramine is a medication used to treat depression. It belongs to a class of drugs called tricyclic antidepressants, which work by affecting chemicals in the brain that influence mood. Desipramine is primarily used for depression but can also be used for certain types of nerve pain. It helps improve mood and relieve pain by balancing neurotransmitters, which are chemicals that transmit signals in the brain. Desipramine is usually part of a comprehensive treatment plan that includes therapy and lifestyle changes.
Directions for Use
For how long do I take Desipramine?
Desipramine is usually taken long-term for chronic conditions like depression. The duration of use depends on your response to the medication and your doctor's advice. For some, it may be a lifelong treatment, while others may use it for a shorter period. Always follow your doctor's instructions and discuss any concerns about the duration of your treatment. Do not stop taking Desipramine without consulting your doctor.
How do I dispose of Desipramine?
To dispose of Desipramine, take it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away.
How do I take Desipramine?
Take Desipramine as prescribed by your doctor, usually once or twice daily. It's best to take it at the same time each day, either in the morning or evening. You can take it with or without food. If you have trouble swallowing pills, ask your doctor if it can be crushed. Avoid alcohol while taking Desipramine, as it can increase side effects. If you miss a dose, take it as soon as you remember, unless it's close to your next dose. In that case, skip the missed dose. Never double up on doses.
How long does it take for Desipramine to start working?
Desipramine may start to work within a few days, but it can take several weeks to achieve its full therapeutic effect. The time it takes to work can vary based on individual factors like age, overall health, and the condition being treated. It's important to take Desipramine exactly as prescribed and give it time to work. If you don't notice improvement after a few weeks, talk with your doctor. They may adjust your dose or suggest other treatment options.
How should I store Desipramine?
Store Desipramine at room temperature, away from moisture and light. Keep it in a tightly closed container to protect it from damage. Avoid storing it in humid places like bathrooms, as moisture can affect its effectiveness. If your pills came in packaging that isn't child-resistant, transfer them to a container that children can't easily open. Always store Desipramine out of children's reach to prevent accidental swallowing.
What is the usual dose of Desipramine?
The usual starting dose of Desipramine for adults is 25 to 50 mg per day, taken once or divided into smaller doses. Your doctor may adjust the dose based on your response and needs. The maximum recommended dose is 300 mg per day. For elderly patients, the starting dose is usually lower, around 10 to 25 mg per day, to minimize side effects. Always follow your doctor's specific dosing instructions for your health needs.
Warnings and Precautions
Can Desipramine be taken safely while breastfeeding?
Desipramine is not recommended while breastfeeding. Limited information is available on whether it passes into breast milk. However, there is a potential risk of adverse effects on the breastfed infant, such as sedation or irritability. If you're taking Desipramine and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Desipramine be taken safely while pregnant?
Desipramine is not recommended during pregnancy unless absolutely necessary. Limited evidence is available on its safety during pregnancy. Some studies suggest potential risks to the unborn baby, such as withdrawal symptoms after birth. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options. Your doctor can help create a plan that protects both you and your baby.
Can I take Desipramine with other prescription drugs?
Desipramine can interact with several prescription drugs. Major interactions include those with MAO inhibitors, which can cause serious side effects like high blood pressure. Moderate interactions occur with other antidepressants, which may increase the risk of side effects. Always inform your doctor about all medications you are taking to avoid interactions. Your doctor can adjust your treatment plan to ensure safety and effectiveness.
Does Desipramine have adverse effects?
Yes, Desipramine can have adverse effects, which are unwanted reactions to a medication. Common adverse effects include dry mouth, constipation, and dizziness. These occur in a small percentage of users. Serious side effects, like heart problems or seizures, are rare but require immediate medical attention. If you notice any new or worsening symptoms, contact your doctor. They can help determine if the symptoms are related to Desipramine and adjust your treatment if needed.
Does Desipramine have any safety warnings?
Yes, Desipramine has important safety warnings. It can increase the risk of suicidal thoughts, especially in young people. It may also cause heart problems, such as arrhythmias, which are irregular heartbeats. Not following these warnings can lead to serious health issues. If you experience mood changes, chest pain, or irregular heartbeats, seek medical help immediately. Always discuss any concerns with your doctor and follow their advice closely.
Is Desipramine addictive?
Desipramine is not considered addictive or habit-forming. It does not cause cravings or withdrawal symptoms when you stop taking it. However, some people may experience physical dependence, which means their body gets used to the medication. To avoid dependence, follow your doctor's instructions and do not take more than prescribed. If you have concerns about dependence, talk with your doctor for guidance.
Is Desipramine safe for the elderly?
Desipramine can be used by the elderly, but with caution. Older adults are more vulnerable to side effects like dizziness, confusion, and heart problems. These risks are due to age-related changes in the body. Doctors usually start with a lower dose for elderly patients to minimize side effects. Regular monitoring is important to ensure safety and effectiveness. Always follow your doctor's advice when taking Desipramine.
Is it safe to drink alcohol while taking Desipramine?
It's best to avoid alcohol while taking Desipramine. Alcohol can increase the risk of side effects like drowsiness and dizziness. It can also interfere with the effectiveness of the medication. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like increased drowsiness or dizziness. Talk with your doctor about alcohol use while taking Desipramine to get personalized advice.
Is it safe to exercise while taking Desipramine?
Yes, you can exercise while taking Desipramine, but be mindful of side effects. This medication can cause dizziness or drowsiness, which might affect your ability to exercise safely. Start with light activities and see how your body responds. Drink plenty of water to stay hydrated. If you feel dizzy or unusually tired, stop exercising and rest. Talk with your doctor if you have concerns about your exercise routine.
Is it safe to stop Desipramine?
It's not safe to stop Desipramine suddenly. Doing so can cause withdrawal symptoms like nausea, headache, and irritability. Desipramine is usually used long-term for conditions like depression. Stopping it abruptly can worsen your condition. Always talk with your doctor before stopping Desipramine. They may suggest gradually reducing your dose to minimize withdrawal symptoms and keep your condition under control.
What are the most common side effects of Desipramine?
Common side effects of Desipramine include dry mouth, constipation, and dizziness. These are unwanted reactions that can happen when taking the medication. The frequency of these side effects varies, but they are generally not experienced by everyone. If you notice new symptoms after starting Desipramine, they might be temporary or unrelated to the medication. It's important to talk with your doctor before stopping any medication.
Who should avoid taking Desipramine?
Desipramine should not be used if you have a known allergy to it or its ingredients. It's also contraindicated in people who have recently had a heart attack or have severe heart problems, as it can worsen these conditions. Caution is needed if you have a history of seizures or bipolar disorder. Always consult your doctor about your medical history before starting Desipramine to ensure it's safe for you.
