Desipramine
Depressive Disorder, Pain ... show more
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Tricyclic Antidepressant
Controlled Drug Substance
NO
Desipramine
Summary
Desipramine is primarily used for the treatment of depression. It helps improve mood and mental balance in individuals with depressive disorders.
Desipramine works by increasing certain natural substances in the brain that help maintain mental balance. It blocks the reuptake of norepinephrine and serotonin in the brain, restoring normal levels of these neurotransmitters.
For adults, the usual daily dose of Desipramine is between 100 mg to 200 mg per day. In more severe cases, the dose may be increased to 300 mg per day if necessary. It's taken orally, with or without food.
Common side effects include nausea, drowsiness, and dry mouth. Serious adverse effects can include irregular heartbeat, seizures, and severe mood changes.
Desipramine carries a risk of suicidal thoughts, especially in young people. It should not be used with MAOIs or in those with recent heart attacks. It's not recommended for children or during breastfeeding.
Indications and Purpose
How does Desipramine work?
Desipramine works by blocking the re-uptake of norepinephrine and serotonin in the brain, which helps to restore normal levels of these neurotransmitters and improve mood balance. This action helps alleviate symptoms of depression.
Is Desipramine effective?
Desipramine is a tricyclic antidepressant that works by increasing certain natural substances in the brain needed for mental balance. It is effective in treating depression, with therapeutic effects often seen within 2 to 3 weeks of starting treatment.
What is Desipramine?
Desipramine is a tricyclic antidepressant used to treat depression. It works by increasing the levels of certain natural substances in the brain that help maintain mental balance. It is important to follow your doctor's instructions and report any side effects.
Directions for Use
For how long do I take Desipramine?
Desipramine is typically used for several weeks to see its full benefits. It may take 2 to 3 weeks to feel the full effect. The duration of use depends on the individual's response and the doctor's recommendation.
How do I take Desipramine?
Desipramine can be taken with or without food, usually at the same time each day. There are no specific food restrictions, but it is important to follow your doctor's instructions and discuss any dietary concerns with them.
How long does it take for Desipramine to start working?
Desipramine may take 2 to 3 weeks to show its full benefits. Some people may notice improvements in their symptoms sooner, but it is important to continue taking the medication as prescribed and attend follow-up appointments with your doctor.
How should I store Desipramine?
Store Desipramine in its original container, tightly closed, at room temperature away from excess heat and moisture. Keep it out of reach of children and dispose of it properly through a take-back program if no longer needed.
What is the usual dose of Desipramine?
For adults, the usual daily dose of Desipramine is between 100 mg to 200 mg per day. In more severe cases, the dose may be increased to 300 mg per day if necessary. Desipramine is not recommended for use in children.
Warnings and Precautions
Can Desipramine be taken safely while breastfeeding?
Desipramine is not recommended while breastfeeding due to potential risks to the infant. If treatment is necessary, discuss the risks and benefits with your doctor to determine the best course of action.
Can Desipramine be taken safely while pregnant?
Desipramine should be used during pregnancy only if the potential benefits justify the risks. There is a pregnancy registry for monitoring outcomes, but strong evidence on fetal harm is not established. Consult your doctor for personalized advice.
Can I take Desipramine with other prescription drugs?
Desipramine should not be used with MAOIs due to the risk of serotonin syndrome. It may interact with other medications like cimetidine, SSRIs, and certain anticholinergic drugs, requiring dose adjustments or additional monitoring.
Is Desipramine safe for the elderly?
For elderly patients, lower doses of Desipramine are recommended due to increased sensitivity and potential for side effects. The elderly may experience a higher risk of falls and confusion. Close monitoring and dose adjustments are advised.
Is it safe to drink alcohol while taking Desipramine?
Drinking alcohol while taking Desipramine can exaggerate the effects of alcohol, potentially increasing the risk of side effects such as drowsiness and impaired judgment. It is advisable to avoid alcohol or consult your doctor for guidance.
Is it safe to exercise while taking Desipramine?
Desipramine may cause drowsiness or dizziness, which could affect your ability to exercise safely. It is important to understand how the medication affects you before engaging in physical activities. Consult your doctor for personalized advice.
Who should avoid taking Desipramine?
Desipramine carries a risk of suicidal thoughts, especially in young people. It should not be used with MAOIs or in those with recent heart attacks. Patients should be monitored for mood changes, and it is not recommended for children.