Deflazacort
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Corticosteroid
Controlled Drug Substance
No
Deflazacort
Summary
Deflazacort is a medication used to treat Duchenne muscular dystrophy (DMD), a muscle weakening disease, in children aged 5 and older.
Deflazacort works by reducing inflammation and suppressing the immune system. It turns into an active form that attaches to a part of cells called the glucocorticoid receptor. This triggers a series of events that reduce production of inflammatory substances and suppress the immune response.
Deflazacort is taken once daily by mouth. The recommended dose is about 0.9 mg for each kilogram of body weight. It can be taken with or without food, but not with grapefruit juice.
Common side effects include weight gain, increased appetite, a round face (Cushingoid appearance), upper respiratory infections (common cold), frequent urination, nose and throat inflammation, excessive hair growth, and irritability.
Deflazacort should not be taken by people who are allergic to it or any of its ingredients. It should be used with caution during pregnancy and breastfeeding. Stopping Deflazacort suddenly can lead to steroid withdrawal syndrome, causing symptoms like loss of appetite, nausea, vomiting, tiredness, and headache.
Indications and Purpose
How does Deflazacort work?
Deflazacort is a corticosteroid that reduces inflammation and alters the immune system's response. It works by decreasing the production of substances that cause inflammation and suppressing the immune system to prevent tissue damage.
Is Deflazacort effective?
Deflazacort has been shown to be effective in treating Duchenne muscular dystrophy (DMD) by improving muscle strength and function. Clinical studies have demonstrated its benefits in managing symptoms and slowing disease progression in patients with DMD.
What is Deflazacort?
Deflazacort is a corticosteroid used to treat Duchenne muscular dystrophy (DMD) by reducing inflammation and modifying the immune system. It helps improve muscle function and slows disease progression. The medication works by decreasing inflammation and altering immune responses.
Directions for Use
For how long do I take Deflazacort?
The duration of Deflazacort use varies depending on the condition being treated and the patient's response to the medication. It can be used for short-term treatment of acute conditions or long-term management of chronic diseases. Always follow your doctor's guidance on the duration of use.
How do I dispose of Deflazacort?
If you can, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so they don't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag and throw it away.
How do I take Deflazacort?
Deflazacort can be taken with or without food, but should not be taken with grapefruit juice. If you have difficulty swallowing tablets, they can be crushed and mixed with applesauce. Always follow your doctor's instructions regarding dosage and administration.
How long does it take for Deflazacort to start working?
Deflazacort typically begins to work within a few hours to a few days, depending on the condition being treated. However, noticeable improvements in symptoms may take longer. Always follow your doctor's guidance and report any concerns about effectiveness.
How should I store Deflazacort?
Store Deflazacort in its original container, tightly closed, at room temperature away from excess heat and moisture. Do not store it in the bathroom. Dispose of any unused suspension liquid after one month. Keep it out of reach of children.
What is the usual dose of Deflazacort?
For adults, the usual maintenance dose of Deflazacort is typically within the range of 3 to 18 mg per day, depending on the condition being treated. For children, the dose is often calculated based on body weight, typically ranging from 0.25 to 1.5 mg/kg/day. Always follow your doctor's specific dosage instructions.
Warnings and Precautions
Can Deflazacort be taken safely while breastfeeding?
Deflazacort can pass into breast milk and may affect a nursing infant. The benefits of breastfeeding should be weighed against the potential risks of the medication. Consult your doctor for personalized advice on using Deflazacort while breastfeeding.
Can Deflazacort be taken safely while pregnant?
Deflazacort should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There is no strong evidence from human studies on fetal harm, but corticosteroids can cross the placenta and may affect fetal development. Consult your doctor for personalized advice.
Can I take Deflazacort with other prescription drugs?
Deflazacort interacts with CYP3A4 inhibitors and inducers, which can alter its effectiveness. It should not be used with grapefruit juice, and caution is advised when taken with drugs like clarithromycin or rifampin. Always inform your doctor of all medications you are taking.
Does Deflazacort have adverse effects?
Adverse effects are unwanted or harmful effects caused by a medicine. Deflazacort can cause adverse effects like weight gain, increased appetite, mood changes, and high blood pressure. Serious but rare effects include vision problems and severe mood swings, which need immediate medical attention. Always report new symptoms to your healthcare provider and consult them before stopping the medicine.
Does Deflazacort have any safety warnings?
Deflazacort comes with safety warnings. It can weaken the immune system, increasing infection risk. Watch for signs like fever or sore throat. It may cause high blood pressure or blood sugar changes, so monitor these regularly. Long-term use can lead to bone thinning, so discuss calcium supplements with your doctor. Always report unusual symptoms to your healthcare provider.
Is Deflazacort addictive?
Deflazacort is not known to be addictive or habit-forming. It does not cause physical or psychological dependence. However, it's important to follow your doctor's instructions and not to stop taking it suddenly without medical advice. If you have concerns about your medication, discuss them with your healthcare provider.
Is Deflazacort safe for the elderly?
Elderly patients using Deflazacort should be monitored closely due to the increased risk of osteoporosis, hypertension, and other side effects. It's important to use the lowest effective dose and to have regular check-ups with a healthcare provider to manage any potential complications.
Is it safe to drink alcohol while taking Deflazacort?
Most people tolerate Deflazacort well, and occasional alcoholic drinks should not affect the way this medicine works. There are no well-established interactions between Deflazacort and alcohol. However, alcohol can increase the risk of stomach irritation and other side effects. It's best to consume alcohol in moderation and consult your healthcare provider if you have any concerns.
Is it safe to exercise while taking Deflazacort?
Deflazacort does not inherently limit the ability to exercise. However, it may cause muscle weakness or joint pain, which could affect physical activity. If you experience these symptoms, consult your doctor for advice on managing them while maintaining an exercise routine.
Is it safe to stop Deflazacort?
Deflazacort is often used for long-term management of chronic conditions. Stopping it suddenly can lead to withdrawal symptoms or a flare-up of the condition being treated. There may be life-threatening risks if stopped abruptly, especially if taken for a long time. Always consult your doctor before stopping Deflazacort to ensure a safe and gradual reduction in dosage.
What are the most common side effects of Deflazacort?
A side effect is an unwanted effect of a medicine. Common side effects of Deflazacort include weight gain, increased appetite, mood changes, high blood pressure, and trouble sleeping. These may occur when starting the medicine and might not be related to it. Always talk to your healthcare provider before stopping any medicine, as they can help manage side effects.
Who should avoid taking Deflazacort?
Deflazacort should not be used by individuals with known hypersensitivity to the drug or its ingredients. It can cause serious side effects like adrenal insufficiency, Cushing's syndrome, and increased risk of infections. Patients should avoid live vaccines and inform their doctor of any existing health conditions before starting treatment.
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