Deflazacort
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Corticosteroid
Controlled Drug Substance
NO
Deflazacort
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Click HereSummary
Deflazacort is a medication used to treat Duchenne muscular dystrophy (DMD), a muscle weakening disease, in children aged 5 and older.
Deflazacort works by reducing inflammation and suppressing the immune system. It turns into an active form that attaches to a part of cells called the glucocorticoid receptor. This triggers a series of events that reduce production of inflammatory substances and suppress the immune response.
Deflazacort is taken once daily by mouth. The recommended dose is about 0.9 mg for each kilogram of body weight. It can be taken with or without food, but not with grapefruit juice.
Common side effects include weight gain, increased appetite, a round face (Cushingoid appearance), upper respiratory infections (common cold), frequent urination, nose and throat inflammation, excessive hair growth, and irritability.
Deflazacort should not be taken by people who are allergic to it or any of its ingredients. It should be used with caution during pregnancy and breastfeeding. Stopping Deflazacort suddenly can lead to steroid withdrawal syndrome, causing symptoms like loss of appetite, nausea, vomiting, tiredness, and headache.
Indications and Purpose
What is Deflazacort used for?
Deflazacort is primarily indicated for the treatment of Duchenne muscular dystrophy (DMD) in patients 5 years of age and older. It helps improve muscle strength and function in individuals with this condition.
How does Deflazacort work?
Deflazacort is a corticosteroid that reduces inflammation and alters the immune system's response. It works by decreasing the production of substances that cause inflammation and suppressing the immune system to prevent tissue damage.
Is Deflazacort effective?
Deflazacort has been shown to be effective in treating Duchenne muscular dystrophy (DMD) by improving muscle strength and function. Clinical studies have demonstrated its benefits in managing symptoms and slowing disease progression in patients with DMD.
How does one know if Deflazacort is working?
The benefit of Deflazacort is evaluated through regular medical check-ups, where doctors assess symptom improvement and monitor for side effects. Blood pressure and lab tests may be conducted to ensure the medication is working effectively and safely.
Directions for Use
What is the usual dose of Deflazacort?
For adults, the usual maintenance dose of Deflazacort is typically within the range of 3 to 18 mg per day, depending on the condition being treated. For children, the dose is often calculated based on body weight, typically ranging from 0.25 to 1.5 mg/kg/day. Always follow your doctor's specific dosage instructions.
How do I take Deflazacort?
Deflazacort can be taken with or without food, but should not be taken with grapefruit juice. If you have difficulty swallowing tablets, they can be crushed and mixed with applesauce. Always follow your doctor's instructions regarding dosage and administration.
For how long do I take Deflazacort?
The duration of Deflazacort use varies depending on the condition being treated and the patient's response to the medication. It can be used for short-term treatment of acute conditions or long-term management of chronic diseases. Always follow your doctor's guidance on the duration of use.
How long does it take for Deflazacort to start working?
Deflazacort typically begins to work within a few hours to a few days, depending on the condition being treated. However, noticeable improvements in symptoms may take longer. Always follow your doctor's guidance and report any concerns about effectiveness.
How should I store Deflazacort?
Store Deflazacort in its original container, tightly closed, at room temperature away from excess heat and moisture. Do not store it in the bathroom. Dispose of any unused suspension liquid after one month. Keep it out of reach of children.
Warnings and Precautions
Who should avoid taking Deflazacort?
Deflazacort should not be used by individuals with known hypersensitivity to the drug or its ingredients. It can cause serious side effects like adrenal insufficiency, Cushing's syndrome, and increased risk of infections. Patients should avoid live vaccines and inform their doctor of any existing health conditions before starting treatment.
Can I take Deflazacort with other prescription drugs?
Deflazacort interacts with CYP3A4 inhibitors and inducers, which can alter its effectiveness. It should not be used with grapefruit juice, and caution is advised when taken with drugs like clarithromycin or rifampin. Always inform your doctor of all medications you are taking.
Can I take Deflazacort with vitamins or supplements?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
Can Deflazacort be taken safely while pregnant?
Deflazacort should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There is no strong evidence from human studies on fetal harm, but corticosteroids can cross the placenta and may affect fetal development. Consult your doctor for personalized advice.
Can Deflazacort be taken safely while breastfeeding?
Deflazacort can pass into breast milk and may affect a nursing infant. The benefits of breastfeeding should be weighed against the potential risks of the medication. Consult your doctor for personalized advice on using Deflazacort while breastfeeding.
Is Deflazacort safe for the elderly?
Elderly patients using Deflazacort should be monitored closely due to the increased risk of osteoporosis, hypertension, and other side effects. It's important to use the lowest effective dose and to have regular check-ups with a healthcare provider to manage any potential complications.
Is it safe to exercise while taking Deflazacort?
Deflazacort does not inherently limit the ability to exercise. However, it may cause muscle weakness or joint pain, which could affect physical activity. If you experience these symptoms, consult your doctor for advice on managing them while maintaining an exercise routine.
Is it safe to drink alcohol while taking Deflazacort?
From all available and reliable information, there is no confirmed data on this. Please consult a doctor for personalized advice.
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