Deferiprone
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
Iron Chelator
Controlled Drug Substance
No
Deferiprone
Summary
Deferiprone is used to treat conditions like thalassemia and sickle cell disease, which lead to excessive iron accumulation in the body due to frequent blood transfusions.
Deferiprone is an iron-chelating agent. It binds to excess iron in the body, forming a stable complex that is primarily excreted through urine. This reduces iron overload and prevents oxidative damage to vital organs like the heart and liver.
Deferiprone is usually taken orally two or three times a day. The usual dose for adults is 75 mg/kg/day divided into three doses, up to a maximum of 99 mg/kg/day. For children aged three years and older, the dosing is similar and based on body weight.
Common side effects include nausea, vomiting, stomach pain, joint pain, and elevated liver enzymes. It can also cause low neutrophil count, a type of white blood cell, which increases the risk of infections. Less common side effects include diarrhea, changes in appetite, and back pain.
Deferiprone should not be used by breastfeeding individuals or those with certain blood disorders. It should not be taken with medicines that lower white blood cell counts or with certain drugs that interfere with its breakdown. It's also advised to leave at least four hours between taking Deferiprone and anything containing iron, aluminum, or zinc.
Indications and Purpose
How does Deferiprone work?
Deferiprone works by binding to excess iron in the body, forming a complex that is excreted through urine. This process helps reduce iron levels in the body, preventing damage to organs caused by iron overload. Think of it like a magnet attracting and removing excess iron, helping to keep your body healthy.
Is Deferiprone effective?
Deferiprone is effective in treating iron overload in patients with thalassemia, which is a blood disorder that causes the body to make an abnormal form of hemoglobin. Clinical studies show that Deferiprone helps reduce iron levels in the body, improving health outcomes for patients. Always follow your doctor's instructions to ensure the best results.
What is Deferiprone?
Deferiprone is a medication used to treat iron overload in patients with thalassemia, which is a blood disorder that causes the body to make an abnormal form of hemoglobin. It works by binding to excess iron in the body, allowing it to be excreted through urine. This helps prevent damage to organs caused by too much iron.
Directions for Use
For how long do I take Deferiprone?
Deferiprone is usually a long-term medication for managing iron overload in conditions like thalassemia. You'll typically take Deferiprone every day as a lifelong treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your Deferiprone treatment.
How do I dispose of Deferiprone?
If you can, bring unused Deferiprone to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Deferiprone?
Take Deferiprone exactly as your doctor prescribes. It's usually taken three times a day, with or without food. You can crush the tablets if needed. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. Then, skip the missed dose and continue your regular schedule. Don't take two doses at once. Always follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for Deferiprone to start working?
Deferiprone starts working in your body shortly after you take it, but it may take several weeks to see significant changes in your iron levels. The time it takes to achieve full therapeutic effect can vary based on individual factors like your iron levels and overall health. Regular blood tests will help monitor its effectiveness.
How should I store Deferiprone?
Store Deferiprone at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. Always keep Deferiprone out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Deferiprone?
The usual starting dose of Deferiprone for adults is 25 mg/kg, taken three times a day. Your doctor may adjust your dose based on your response and any side effects. The maximum recommended dose is 33 mg/kg three times a day. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can Deferiprone be taken safely while breastfeeding?
Deferiprone is not recommended while breastfeeding. We don't have much information about whether this medication passes into human breast milk. If you're taking Deferiprone and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Deferiprone be taken safely while pregnant?
Deferiprone is not recommended during pregnancy due to limited evidence on its safety. Animal studies have shown potential risks to the fetus. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a pregnancy-specific treatment plan that protects both you and your baby.
Can I take Deferiprone with other prescription drugs?
Deferiprone can interact with other medications, increasing the risk of side effects. For example, combining it with drugs that affect blood cell production can increase the risk of low white blood cells. Always tell your doctor about all the medications you take to avoid harmful interactions.
Does Deferiprone have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Deferiprone include nausea, vomiting, and abdominal pain. These occur in more than 10% of users. Serious side effects include a decrease in white blood cells, which can lead to infections. If you notice any new or worsening symptoms, contact your doctor immediately.
Does Deferiprone have any safety warnings?
Yes, Deferiprone has important safety warnings. It can cause a decrease in white blood cells, which are cells that help fight infections. This can increase your risk of infections. Regular blood tests are needed to monitor your blood cell levels. If you experience symptoms like fever or sore throat, contact your doctor immediately. Not adhering to these warnings can lead to serious health issues.
Is Deferiprone addictive?
Deferiprone is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. If you have concerns about medication dependence, you can feel confident that Deferiprone doesn't carry this risk while managing your health condition.
Is Deferiprone safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Deferiprone, such as liver problems and decreased white blood cells. Regular monitoring is important to ensure safety. Always consult your doctor about the risks and benefits of using Deferiprone if you are elderly.
Is it safe to drink alcohol while taking Deferiprone?
It's best to avoid alcohol while taking Deferiprone. Alcohol can increase the risk of liver problems, which is a concern with this medication. If you do choose to drink occasionally, limit how much alcohol you consume and talk with your doctor about alcohol use while taking Deferiprone to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Deferiprone?
You can exercise while taking Deferiprone, but keep a few things in mind. This medication can cause fatigue, which might affect your exercise capacity. To exercise safely, listen to your body and rest if you feel tired. Most people can maintain their regular exercise routine while taking Deferiprone, but check with your doctor if you have concerns about your specific situation.
Is it safe to stop Deferiprone?
Stopping Deferiprone suddenly can cause your iron levels to rise again, which can be harmful. Always talk with your doctor before stopping Deferiprone. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
What are the most common side effects of Deferiprone?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Deferiprone include nausea, vomiting, and abdominal pain, affecting more than 10% of users. If you notice new symptoms after starting Deferiprone, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Deferiprone?
Don't take Deferiprone if you're allergic to it or its ingredients. It's also contraindicated in patients with severe neutropenia, which is a low level of white blood cells. This medication should be used with caution in patients with liver problems. Always consult your doctor about these concerns.
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