Deferasirox
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
NO
Pharmaceutical Class
Iron Chelator
Controlled Drug Substance
No
deferasirox
Summary
Deferasirox is used to treat chronic iron overload, which is an excess of iron in the body due to frequent blood transfusions. It is often prescribed for patients with conditions like thalassemia or sickle cell anemia, where regular transfusions are necessary.
Deferasirox works by binding to excess iron in the body, which allows it to be excreted through urine and feces. This process helps prevent damage to organs caused by too much iron, making it effective for treating chronic iron overload.
The usual starting dose of Deferasirox for adults is 20 mg per kilogram of body weight, taken once daily. It should be taken on an empty stomach, at least 30 minutes before eating. The dose may be adjusted based on response and blood tests, with a maximum of 40 mg per kilogram daily.
Common side effects of Deferasirox include nausea, vomiting, diarrhea, and abdominal pain. These effects are usually mild to moderate. If you experience severe or persistent symptoms, it's important to talk with your doctor.
Deferasirox should not be used in patients with severe kidney or liver problems, as it can worsen these conditions. It is also contraindicated in patients with high-risk myelodysplastic syndromes or advanced malignancies. Regular monitoring of kidney and liver function is necessary.
Indications and Purpose
How does Deferasirox work?
Deferasirox works by binding to excess iron in the body, allowing it to be excreted through urine and feces. Think of it like a magnet attracting iron particles, helping to remove them from your body. This process helps prevent damage to organs caused by too much iron, making it effective for treating chronic iron overload.
Is Deferasirox effective?
Deferasirox is effective in treating chronic iron overload due to blood transfusions. It works by binding to excess iron, allowing it to be excreted from the body. Clinical studies show it significantly reduces iron levels in patients, improving health outcomes. Always follow your doctor's instructions for the best results.
What is Deferasirox?
Deferasirox is a medication used to treat chronic iron overload, which is an excess of iron in the body due to blood transfusions. It belongs to a class of drugs called iron chelators, which work by binding to excess iron and allowing it to be excreted from the body. This helps prevent damage to organs caused by too much iron.
Directions for Use
For how long do I take Deferasirox?
Deferasirox is usually a long-term medication for managing chronic iron overload. You'll typically take it daily as a lifelong treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response and any side effects you experience. Always talk with your doctor before changing or stopping your treatment.
How do I dispose of Deferasirox?
Dispose of unused Deferasirox by taking it to a drug take-back program or collection site at a pharmacy or hospital. If unavailable, mix the medication with an undesirable substance like used coffee grounds, seal it in a plastic bag, and throw it away in the trash. This prevents harm to people and the environment.
How do I take Deferasirox?
Take Deferasirox once daily, preferably on an empty stomach, at least 30 minutes before eating. It should not be crushed or chewed. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. Then skip the missed dose and continue your normal schedule. Never take two doses at once. Avoid taking it with dairy products or antacids containing aluminum or magnesium.
How long does it take for Deferasirox to start working?
Deferasirox starts working in your body shortly after you take it, but it may take several weeks to see significant changes in iron levels. The full therapeutic effect can take months, depending on your condition and response to treatment. Regular blood tests help monitor its effectiveness. Always take it as prescribed for the best results.
How should I store Deferasirox?
Store Deferasirox at room temperature, away from moisture and light. Keep it in a tightly closed container. Do not store it in humid places like bathrooms. Always keep it out of reach of children to prevent accidental ingestion. Check the expiration date regularly and dispose of any unused or expired medication properly.
What is the usual dose of Deferasirox?
The usual starting dose of Deferasirox for adults is 20 mg/kg once daily. Your doctor may adjust the dose based on your response and blood tests. The maximum recommended dose is 40 mg/kg daily. For children, the dose is based on body weight and requires careful monitoring. Always follow your doctor's specific dosing instructions.
Warnings and Precautions
Can Deferasirox be taken safely while breastfeeding?
Deferasirox is not recommended while breastfeeding due to limited information on its excretion into breast milk. Potential risks to the infant's developing organs, like kidneys, are a concern. If you're taking Deferasirox and want to breastfeed, discuss safer medication options with your doctor.
Can Deferasirox be taken safely while pregnant?
Deferasirox is not recommended during pregnancy due to limited safety data. Animal studies suggest potential risks, but human data is lacking. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take Deferasirox with other prescription drugs?
Deferasirox can interact with certain medications, increasing the risk of adverse effects. For example, it can interact with anticoagulants, increasing bleeding risk. It may also interact with other iron chelators, leading to increased side effects. Always inform your doctor about all medications you are taking to prevent interactions.
Does Deferasirox have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Deferasirox include nausea, vomiting, diarrhea, and abdominal pain. Serious effects can include kidney or liver problems and gastrointestinal bleeding. If you notice any new or worsening symptoms, contact your doctor immediately. Regular monitoring helps manage these risks.
Does Deferasirox have any safety warnings?
Yes, Deferasirox has important safety warnings. It can cause kidney and liver problems, and regular monitoring of kidney and liver function is necessary. It may also cause gastrointestinal bleeding. Not adhering to these warnings can lead to serious health issues. Always follow your doctor's advice and report any unusual symptoms immediately.
Is Deferasirox addictive?
Deferasirox is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. This medication works by removing excess iron from the body and does not affect brain chemistry in ways that could lead to addiction. You can feel confident that Deferasirox doesn't carry this risk.
Is Deferasirox safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Deferasirox, such as kidney and liver problems. Regular monitoring is important to ensure safety. Discuss any concerns with your doctor, who can adjust the treatment plan based on your specific health needs.
Is it safe to drink alcohol while taking Deferasirox?
It's best to avoid alcohol while taking Deferasirox. Alcohol can increase the risk of liver problems, which are a concern with this medication. If you choose to drink, limit your intake and watch for symptoms like nausea or abdominal pain. Talk with your doctor about alcohol use while on Deferasirox.
Is it safe to exercise while taking Deferasirox?
You can exercise while taking Deferasirox, but be mindful of potential side effects like dizziness or fatigue. These might affect your exercise capacity. To exercise safely, stay hydrated and watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest.
Is it safe to stop Deferasirox?
Stopping Deferasirox suddenly can lead to a buildup of iron in your body, which can be harmful. Always talk with your doctor before stopping the medication. They might suggest gradually reducing your dose or switching to a different treatment to manage your condition safely.
What are the most common side effects of Deferasirox?
Side effects are unwanted reactions to a medication. Common side effects of Deferasirox include nausea, vomiting, diarrhea, and abdominal pain. These occur in a significant number of patients. If you experience new symptoms, they might be temporary or unrelated to the medication. Always talk with your doctor before stopping any medication.
Who should avoid taking Deferasirox?
Deferasirox should not be used in patients with severe kidney or liver problems, as it can worsen these conditions. It is also contraindicated in patients with high-risk myelodysplastic syndromes or advanced malignancies. Always consult your doctor about any health concerns before starting Deferasirox.
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