Dasatinib
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
Definite
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
dasatinib
Summary
Dasatinib is used to treat chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL), which are types of cancer affecting blood and bone marrow.
Dasatinib works by blocking proteins called tyrosine kinases, which help cancer cells grow. By inhibiting these proteins, it slows or stops cancer cell growth.
The usual starting dose for adults is 100 mg once daily, taken as a tablet. Your doctor may adjust the dose based on your response and side effects.
Common side effects include low blood cell counts, which can increase infection risk, and fluid retention, which may cause swelling.
Dasatinib can cause fluid retention and increase bleeding risk. It's not recommended for those with severe liver issues or during pregnancy.
Indications and Purpose
How does Dasatinib work?
Dasatinib works by inhibiting certain proteins called tyrosine kinases, which are involved in the growth and spread of cancer cells. Think of it like turning off a switch that allows cancer cells to multiply. By blocking these proteins, Dasatinib helps slow down or stop the growth of cancer cells. This action makes it effective in treating certain types of leukemia, such as chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). Your doctor will monitor your progress to ensure the medication is working effectively.
Is Dasatinib effective?
Dasatinib is effective in treating certain types of cancer, such as chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). It works by inhibiting specific proteins that promote cancer cell growth. Clinical studies show that Dasatinib can significantly improve health outcomes in patients with these conditions. It helps reduce the number of cancer cells and can lead to remission. Your doctor will monitor your progress with regular tests to ensure the medication is working effectively.
What is Dasatinib?
Dasatinib is a medication used to treat certain types of cancer, such as chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). It belongs to a class of drugs called tyrosine kinase inhibitors, which work by blocking specific proteins that promote cancer cell growth. By inhibiting these proteins, Dasatinib helps slow down or stop the growth of cancer cells. It is usually used as part of a comprehensive treatment plan, which may include other therapies, to manage these conditions effectively.
Directions for Use
For how long do I take Dasatinib?
Dasatinib is usually a long-term medication for managing chronic conditions like chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). You'll typically take Dasatinib every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your conditions to worsen. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Dasatinib treatment.
How do I dispose of Dasatinib?
To dispose of Dasatinib, take it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away. Always keep it out of reach of children and pets.
How do I take Dasatinib?
Take Dasatinib exactly as your doctor prescribes. It's usually taken once daily, either in the morning or evening. You can take it with or without food, but avoid crushing or breaking the tablet. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Avoid grapefruit and grapefruit juice while taking Dasatinib, as they can affect how the medicine works.
How long does it take for Dasatinib to start working?
Dasatinib starts working in your body shortly after you take it, but the full therapeutic effects may take several weeks to become noticeable. The time it takes to see results can vary depending on individual factors like your overall health and the specific condition being treated. Regular blood tests and check-ups with your doctor will help monitor your progress. It's important to take Dasatinib exactly as prescribed for the best results. If you have any concerns about how the medication is working, talk with your healthcare provider.
How should I store Dasatinib?
Store Dasatinib at room temperature, away from moisture and light. Keep it in its original container with the lid tightly closed. Do not store it in the bathroom, where humidity can affect the medication. Always keep Dasatinib out of reach of children and pets to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication. If you have any questions about storage, ask your pharmacist or healthcare provider.
What is the usual dose of Dasatinib?
The usual starting dose of Dasatinib for adults is 100 mg once daily. Your doctor may adjust the dose based on your response and any side effects. The maximum recommended dose is 140 mg daily. For special populations, such as children or the elderly, dose adjustments may be necessary. Always follow your doctor's specific dosing instructions for your health needs. Do not change your dose without consulting your healthcare provider.
Warnings and Precautions
Can Dasatinib be taken safely while breastfeeding?
Dasatinib is not recommended while breastfeeding. There is limited information on whether it passes into human breast milk, but it may pose risks to a nursing infant. The medication could affect the baby's development. If you are taking Dasatinib and wish to breastfeed, talk with your doctor about safer alternatives. They can help you choose a treatment that allows you to nurse your baby safely. Always inform your healthcare provider about your breastfeeding plans.
Can Dasatinib be taken safely while pregnant?
Dasatinib is not recommended during pregnancy. It can harm an unborn baby, as it may affect fetal development. There is limited information on its use in pregnant women, but animal studies suggest potential risks. If you are pregnant or planning to become pregnant, talk with your doctor about the safest treatment options. They can help create a plan that protects both you and your baby. Always inform your healthcare provider if you become pregnant while taking Dasatinib.
Can I take Dasatinib with other prescription drugs?
Dasatinib can interact with several other medications, which may increase the risk of side effects or reduce its effectiveness. For example, antacids can interfere with Dasatinib absorption, and certain antibiotics or antifungals can increase its levels in the blood. Always inform your doctor about all the medications you are taking, including over-the-counter drugs and supplements. They can help manage these interactions and adjust your treatment plan if necessary. Regular monitoring is important to ensure safe and effective treatment.
Does Dasatinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Dasatinib include low blood cell counts, which can increase infection risk, and fluid retention, which may cause swelling. Serious side effects include bleeding and heart problems. If you notice any new or worsening symptoms, contact your doctor immediately. They can help determine if these are related to Dasatinib and adjust your treatment as needed. Regular monitoring is important to manage any adverse effects effectively.
Does Dasatinib have any safety warnings?
Yes, Dasatinib has important safety warnings. It can cause fluid retention, which may lead to swelling and shortness of breath. It may also increase the risk of bleeding and infections. Not following these warnings can lead to serious health issues. If you experience symptoms like unusual bruising, bleeding, or signs of infection, contact your doctor immediately. Regular monitoring by your healthcare provider is essential to manage these risks effectively.
Is Dasatinib addictive?
Dasatinib is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Dasatinib works by inhibiting certain proteins in cancer cells, which does not affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that Dasatinib doesn't carry this risk while managing your health condition.
Is Dasatinib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Dasatinib, such as fluid retention and low blood cell counts. These side effects can lead to serious health issues like heart problems and infections. Regular monitoring by a healthcare provider is important to manage these risks. Dose adjustments may be necessary based on the patient's overall health and response to treatment. Always consult with a doctor before starting Dasatinib if you are elderly.
Is it safe to drink alcohol while taking Dasatinib?
It's best to avoid alcohol while taking Dasatinib. Alcohol can increase the risk of liver damage and worsen side effects like dizziness or nausea. Drinking alcohol may also interfere with the effectiveness of the medication. If you choose to drink occasionally, limit your alcohol intake and watch for any warning signs like unusual fatigue or stomach pain. Talk with your doctor about alcohol use while taking Dasatinib to get personalized advice based on your health situation.
Is it safe to exercise while taking Dasatinib?
You can exercise while taking Dasatinib, but be mindful of your body's response. This medication can cause fatigue and dizziness, which might affect your exercise capacity. If you feel weak or dizzy during physical activity, slow down or stop and rest. Drink plenty of water to stay hydrated. Avoid strenuous activities or high-impact sports if you experience any side effects. Talk with your doctor about your exercise routine to ensure it's safe for your specific situation.
Is it safe to stop Dasatinib?
Stopping Dasatinib suddenly can be risky. It's usually used for long-term treatment of chronic conditions like cancer. Stopping it without medical advice can lead to a return or worsening of your condition. Always talk with your doctor before stopping Dasatinib. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
What are the most common side effects of Dasatinib?
Side effects are unwanted reactions to a medication. Common side effects of Dasatinib include low blood cell counts, which can increase infection risk, and fluid retention, which may cause swelling. Other side effects include nausea, diarrhea, and fatigue. These effects vary from person to person. If you notice new symptoms after starting Dasatinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Dasatinib?
Do not take Dasatinib if you are allergic to it or any of its ingredients. It is contraindicated in patients with severe liver impairment, as it can worsen liver function. Caution is needed in patients with heart problems, as Dasatinib can cause fluid retention and heart issues. Always inform your doctor about your medical history and any other medications you are taking. They can help determine if Dasatinib is safe for you.
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