Dapagliflozin + Saxagliptin
Find more information about this combination medication at the webpages for dapagliflozin and saxagliptin
Type 2 Diabetes Mellitus
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Advisory
- This medicine contains a combination of 2 drugs dapagliflozin and saxagliptin.
- dapagliflozin and saxagliptin are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
None
Controlled Drug Substance
NO
dapagliflozin + saxagliptin
Summary
Dapagliflozin and saxagliptin are used to manage type 2 diabetes, which is a condition where the body does not use insulin properly, leading to high blood sugar levels. These medications are prescribed when diet and exercise alone are not enough to control blood sugar. They are not suitable for type 1 diabetes, which is a different form of diabetes, or for diabetic ketoacidosis, which is a serious condition involving high blood acid levels.
Dapagliflozin works by blocking a protein in the kidneys called SGLT2, which helps remove excess glucose from the body through urine. Saxagliptin works by inhibiting the DPP-4 enzyme, which increases insulin production and decreases sugar production in the liver. Together, they help lower blood sugar levels in people with type 2 diabetes by addressing different aspects of glucose regulation in the body.
The usual adult daily dose for dapagliflozin is 10 mg, taken once daily. For saxagliptin, the typical dose is 5 mg, also taken once daily. Both medications are usually taken in the morning, with or without food. It's important to follow the healthcare provider's instructions and not to adjust the dose without consulting them.
Common side effects of dapagliflozin include urinary tract infections and increased urination. Saxagliptin may cause upper respiratory tract infections and headaches. Both medicines can lead to low blood sugar, especially when used with other diabetes medications. It's important to monitor for these side effects and consult a healthcare provider if they occur.
Important warnings for dapagliflozin include the risk of dehydration and urinary tract infections. Saxagliptin may increase the risk of heart failure. Both medicines can cause low blood sugar, especially when combined with other diabetes drugs. Contraindications include severe kidney disease for dapagliflozin and a history of serious allergic reactions to saxagliptin. Patients should discuss their medical history with their healthcare provider to ensure these medications are safe for them.
Indications and Purpose
How does combination of dapagliflozin and saxagliptin work?
Dapagliflozin works by blocking a protein in the kidneys called SGLT2, which helps remove excess glucose from the body through urine. Saxagliptin works by inhibiting the DPP-4 enzyme, which increases insulin production and decreases sugar production in the liver. Together, they help lower blood sugar levels in people with type 2 diabetes by addressing different aspects of glucose regulation in the body.
How does combination of Dapagliflozin and Saxagliptin work?
Dapagliflozin and Saxagliptin are medications used together to help manage type 2 diabetes. Dapagliflozin works by helping the kidneys remove glucose (sugar) from the bloodstream through urine. This process helps lower blood sugar levels. Saxagliptin, on the other hand, works by increasing the levels of certain natural substances in the body that help control blood sugar. It does this by inhibiting an enzyme called DPP-4, which results in increased insulin release and decreased sugar production by the liver. Together, these medications help improve blood sugar control in people with type 2 diabetes.
How does combination of Saxagliptin and Dapagliflozin work?
Saxagliptin works by inhibiting the DPP-4 enzyme, which increases the levels of incretin hormones, leading to increased insulin production after meals and decreased glucagon release. This helps lower blood sugar levels. Dapagliflozin, on the other hand, inhibits the SGLT2 protein in the kidneys, reducing glucose reabsorption and increasing glucose excretion in the urine. Together, these medications provide a dual mechanism of action, addressing both insulin production and glucose elimination to effectively manage blood sugar levels in type 2 diabetes.
How effective is combination of dapagliflozin and saxagliptin?
Clinical studies have shown that dapagliflozin and saxagliptin effectively lower blood sugar levels in people with type 2 diabetes. Dapagliflozin, by promoting glucose excretion through urine, and saxagliptin, by enhancing insulin secretion and reducing liver sugar production, both contribute to improved HbA1c levels. The combination of these two medicines has been proven to provide better blood sugar control than either medicine alone, offering a comprehensive approach to managing type 2 diabetes.
How effective is combination of Dapagliflozin and Saxagliptin?
The combination of Dapagliflozin and Saxagliptin is used to help control blood sugar levels in adults with type 2 diabetes. Dapagliflozin works by helping the kidneys remove glucose from the bloodstream, while Saxagliptin helps increase the levels of insulin produced after meals and decreases the amount of sugar made by the liver. Together, they can be more effective than using either drug alone, especially when combined with a healthy diet and exercise. However, the effectiveness can vary from person to person, and it's important to follow a healthcare provider's advice to achieve the best results.
How effective is combination of Saxagliptin and Dapagliflozin?
Clinical trials have demonstrated the effectiveness of Saxagliptin and Dapagliflozin in managing type 2 diabetes. Saxagliptin has been shown to improve glycemic control by increasing insulin production and reducing glucagon levels. Dapagliflozin effectively lowers blood sugar by promoting glucose excretion through urine. Together, they provide a comprehensive approach to diabetes management, addressing both insulin production and glucose elimination. Studies have also shown that Dapagliflozin reduces the risk of hospitalization for heart failure and can help manage kidney disease, further supporting its efficacy in treating diabetes-related complications.
Directions for Use
What is the usual dose of combination of dapagliflozin and saxagliptin?
The usual adult daily dose for dapagliflozin is 10 mg, taken once daily. For saxagliptin, the typical dose is 5 mg, also taken once daily. Both medications are usually taken in the morning, with or without food. It's important to follow the healthcare provider's instructions and not to adjust the dose without consulting them.
What is the usual dose of combination of Dapagliflozin and Saxagliptin?
The usual dose for the combination of Dapagliflozin and Saxagliptin is typically one tablet taken once daily. Each tablet usually contains 10 mg of Dapagliflozin and 5 mg of Saxagliptin. However, the exact dosage may vary based on individual health needs and should be determined by a healthcare provider. Dapagliflozin helps the kidneys remove glucose from the bloodstream, while Saxagliptin helps regulate insulin levels after eating.
What is the usual dose of combination of Saxagliptin and Dapagliflozin?
The usual adult daily dose for Saxagliptin is 5 mg, and for Dapagliflozin, it is 10 mg. These doses are typically taken once daily, with or without food. Saxagliptin works by increasing insulin production after meals, while Dapagliflozin helps the kidneys remove excess glucose from the body through urine. When combined, these medications provide a dual approach to managing blood sugar levels in adults with type 2 diabetes. It's important to follow the prescribed dosage and consult with a healthcare provider for any adjustments.
How does one take combination of dapagliflozin and saxagliptin?
Dapagliflozin and saxagliptin can be taken with or without food, usually in the morning. There are no specific food restrictions, but maintaining a balanced diet is important for managing diabetes. It's crucial to follow the healthcare provider's instructions and not to skip doses. Regular monitoring of blood sugar levels is recommended to ensure the medications are working effectively.
How does one take combination of Dapagliflozin and Saxagliptin?
Dapagliflozin and Saxagliptin are medications used together to help control blood sugar levels in adults with type 2 diabetes. They are usually taken as a single tablet that combines both drugs. It is important to follow your healthcare provider's instructions on how to take this medication. Typically, the tablet is taken once daily, with or without food. Dapagliflozin works by helping the kidneys remove glucose from the bloodstream, while Saxagliptin helps increase the levels of insulin produced after meals. Always take the medication at the same time each day to maintain an even level in your blood. Do not split or crush the tablet, and if you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Consult your healthcare provider for personalized advice and to ensure this medication is appropriate for your condition. For more detailed information, you can visit trusted sources like the NHS, DailyMeds, or the National Library of Medicine (NLM).
How does one take combination of Saxagliptin and Dapagliflozin?
Saxagliptin and Dapagliflozin can be taken with or without food, making them convenient for daily use. It's important to take them at the same time each day to maintain consistent blood levels. Patients should follow their healthcare provider's dietary recommendations, which typically include a balanced diet to help manage diabetes. There are no specific food restrictions associated with these medications, but maintaining a healthy diet and regular exercise is crucial for optimal diabetes management.
For how long is combination of dapagliflozin and saxagliptin taken?
Dapagliflozin and saxagliptin are typically used as long-term treatments for managing type 2 diabetes. The duration of use depends on individual response and the healthcare provider's recommendations. Regular follow-ups with the healthcare provider are important to assess the effectiveness and adjust the treatment plan as needed.
For how long is combination of Dapagliflozin and Saxagliptin taken?
The combination of Dapagliflozin and Saxagliptin is typically taken as a long-term treatment for managing type 2 diabetes. The duration of treatment depends on individual health needs and how well the medication is controlling blood sugar levels. It's important to follow the healthcare provider's instructions and have regular check-ups to assess the effectiveness and adjust the treatment as necessary. Always consult with a healthcare professional for personalized advice.
For how long is combination of Saxagliptin and Dapagliflozin taken?
Saxagliptin and Dapagliflozin are typically used as long-term treatments for managing type 2 diabetes. They are not cures for diabetes but are intended to help control blood sugar levels over time. Patients are usually advised to continue taking these medications as prescribed by their healthcare provider, even if they feel well, to maintain effective blood sugar management. Regular monitoring and consultations with a healthcare provider are essential to assess the ongoing effectiveness and make any necessary adjustments.
How long does it take for combination of dapagliflozin and saxagliptin to work?
Dapagliflozin and saxagliptin, when used together, start working within a few hours to help lower blood sugar levels. Dapagliflozin, which is a sodium-glucose co-transporter 2 (SGLT2) inhibitor, works by helping the kidneys remove glucose from the bloodstream. Saxagliptin, which is a dipeptidyl peptidase-4 (DPP-4) inhibitor, helps increase insulin production and decrease the amount of sugar made by the liver. Both medicines work together to improve blood sugar control in people with type 2 diabetes.
How long does it take for combination of Dapagliflozin and Saxagliptin to work?
The combination of Dapagliflozin and Saxagliptin typically starts to work within a few weeks. These medications help to lower blood sugar levels in people with type 2 diabetes. Dapagliflozin works by helping the kidneys remove glucose from the bloodstream, while Saxagliptin helps to increase insulin production and decrease the amount of sugar the liver makes. However, the exact time it takes to notice improvements can vary depending on individual factors such as diet, exercise, and overall health. It's important to follow your healthcare provider's instructions and have regular check-ups to monitor your progress.
How long does it take for combination of Saxagliptin and Dapagliflozin to work?
Saxagliptin and Dapagliflozin, when used together, start working relatively quickly to help control blood sugar levels. Saxagliptin works by increasing insulin production after meals, which can lead to noticeable effects soon after ingestion. Dapagliflozin, on the other hand, works by helping the kidneys remove excess glucose from the body through urine, which also begins to take effect shortly after administration. While the exact time frame can vary based on individual factors, patients may start to see improvements in blood sugar levels within a few days of starting the medication. Both medications work together to provide a comprehensive approach to managing type 2 diabetes.
Warnings and Precautions
Are there harms and risks from taking combination of dapagliflozin and saxagliptin?
Common side effects of dapagliflozin include urinary tract infections and increased urination, while saxagliptin may cause upper respiratory tract infections and headaches. Both medicines can lead to low blood sugar, especially when used with other diabetes medications. Significant adverse effects include the risk of dehydration with dapagliflozin and potential heart failure with saxagliptin. It's important to monitor for these side effects and consult a healthcare provider if they occur.
Are there harms and risks from taking combination of Dapagliflozin and Saxagliptin?
Yes, there are potential harms and risks when taking a combination of Dapagliflozin and Saxagliptin. Dapagliflozin is a medication that helps lower blood sugar levels by causing the kidneys to remove sugar from the body through urine. Saxagliptin helps control blood sugar by increasing the levels of insulin produced after meals. When taken together, these medications can increase the risk of certain side effects. Some common side effects include urinary tract infections, genital infections, and low blood sugar levels (hypoglycemia). More serious risks can include dehydration, which may lead to kidney problems, and a rare but serious condition called ketoacidosis, where the body produces high levels of blood acids called ketones. It's important to discuss with a healthcare provider before starting these medications to understand the potential risks and to ensure they are appropriate for your health condition.
Are there harms and risks from taking combination of Saxagliptin and Dapagliflozin?
Common side effects of Saxagliptin include sore throat, headache, and joint pain, while Dapagliflozin may cause increased urination, stuffy or runny nose, and sore throat. Both medications can lead to changes in blood sugar levels, with symptoms of low blood sugar including shaking, hunger, and sweating. Serious adverse effects include pancreatitis for Saxagliptin and urinary tract infections for Dapagliflozin. Both medications may cause allergic reactions, and Dapagliflozin can lead to dehydration and ketoacidosis. Patients should be aware of these potential side effects and consult their healthcare provider if they experience any severe symptoms.
Can I take combination of dapagliflozin and saxagliptin with other prescription drugs?
Dapagliflozin and saxagliptin can interact with other diabetes medications, increasing the risk of low blood sugar. Saxagliptin may interact with strong CYP3A4/5 inhibitors, which can increase saxagliptin levels in the body. It's important to inform healthcare providers of all prescription medications being taken to manage potential interactions effectively. Regular monitoring of blood sugar levels and adjusting medication doses as needed can help manage these interactions.
Can I take combination of Dapagliflozin and Saxagliptin with other prescription drugs?
Dapagliflozin and Saxagliptin are medications used to manage blood sugar levels in people with type 2 diabetes. When considering taking these drugs with other prescription medications, it is important to consult with a healthcare professional. This is because combining medications can sometimes lead to interactions that may affect how well the drugs work or increase the risk of side effects. According to the NHS, some medications can interact with Dapagliflozin and Saxagliptin, potentially altering their effectiveness or increasing side effects. For example, certain diuretics (water pills) may increase the risk of dehydration when taken with Dapagliflozin. Additionally, other diabetes medications may need to be adjusted to prevent low blood sugar levels. The NLM also advises that patients should inform their healthcare provider about all the medications they are taking, including over-the-counter drugs and supplements, to ensure safe and effective use of Dapagliflozin and Saxagliptin. In summary, while it is possible to take Dapagliflozin and Saxagliptin with other prescription drugs, it should be done under the guidance of a healthcare professional to manage potential interactions and side effects.
Can I take combination of Saxagliptin and Dapagliflozin with other prescription drugs?
Saxagliptin and Dapagliflozin can interact with certain prescription drugs. Saxagliptin's effectiveness can be affected by strong CYP3A4/5 inhibitors like ketoconazole, which can increase its concentration. Dapagliflozin may interact with diuretics, increasing the risk of dehydration. Both medications can increase the risk of hypoglycemia when used with insulin or insulin secretagogues. It's crucial for patients to inform their healthcare provider about all medications they are taking to manage potential interactions effectively and adjust dosages if necessary.
Can I take combination of dapagliflozin and saxagliptin if I am pregnant?
The safety of dapagliflozin and saxagliptin during pregnancy is not well established. Dapagliflozin is generally not recommended during the second and third trimesters due to potential risks to the developing baby. Saxagliptin's effects during pregnancy are also unclear, and it should be used only if the potential benefits justify the risks. Pregnant women should consult their healthcare provider to discuss the safest treatment options for managing diabetes during pregnancy.
Can I take combination of Dapagliflozin and Saxagliptin if I am pregnant?
It is not recommended to take Dapagliflozin and Saxagliptin during pregnancy. According to the NHS and other trusted sources, these medications may not be safe for use during pregnancy as they can potentially harm the developing baby. It is important to consult with a healthcare professional for advice and to discuss alternative treatments for managing your condition during pregnancy.
Can I take combination of Saxagliptin and Dapagliflozin if I am pregnant?
Saxagliptin and Dapagliflozin are not recommended during pregnancy due to potential risks to the developing fetus. Animal studies have shown adverse effects on fetal development, particularly with Dapagliflozin, which can affect kidney development. There is limited data on the use of these medications in pregnant women, so the potential risks are not fully understood. Women who are pregnant or planning to become pregnant should discuss alternative diabetes management options with their healthcare provider to ensure the safety of both mother and child.
Can I take combination of dapagliflozin and saxagliptin while breastfeeding?
The safety of dapagliflozin and saxagliptin during lactation and breastfeeding is not well established. Dapagliflozin is generally not recommended as it may pass into breast milk and affect the nursing infant. Saxagliptin's presence in breast milk is unknown, and caution is advised. Breastfeeding mothers should consult their healthcare provider to weigh the benefits and risks of using these medications while nursing.
Can I take combination of Dapagliflozin and Saxagliptin while breastfeeding?
According to the NHS and NLM, there is limited information on the safety of taking Dapagliflozin and Saxagliptin while breastfeeding. Dapagliflozin is a medication used to lower blood sugar levels in people with type 2 diabetes, and Saxagliptin is another medication that helps control blood sugar levels. Both medications may pass into breast milk, and their effects on a nursing infant are not well studied. It is important to consult with a healthcare professional to weigh the potential benefits and risks before using these medications while breastfeeding.
Can I take combination of Saxagliptin and Dapagliflozin while breastfeeding?
The safety of Saxagliptin and Dapagliflozin during lactation and breastfeeding is not well established. It is unknown whether these medications are excreted in human milk, but animal studies have shown that both drugs can be present in the milk of lactating animals. Due to the potential for serious adverse reactions in breastfed infants, it is generally advised that women do not breastfeed while taking these medications. Patients should discuss alternative treatments with their healthcare provider if they are breastfeeding or planning to breastfeed.
Who should avoid taking combination of dapagliflozin and saxagliptin?
Important warnings for dapagliflozin include the risk of dehydration and urinary tract infections. Saxagliptin may increase the risk of heart failure. Both medicines can cause low blood sugar, especially when combined with other diabetes drugs. Contraindications include severe kidney disease for dapagliflozin and a history of serious allergic reactions to saxagliptin. Patients should discuss their medical history with their healthcare provider to ensure these medications are safe for them.
Who should avoid taking combination of Dapagliflozin and Saxagliptin?
According to trusted sources like the NHS and NLM, certain individuals should avoid taking the combination of Dapagliflozin and Saxagliptin. These include: 1. **People with Severe Kidney Problems**: This combination is not recommended for individuals with severe kidney issues, as it can worsen their condition. 2. **Individuals with a History of Pancreatitis**: Those who have had inflammation of the pancreas should avoid this combination, as it may increase the risk of recurrence. 3. **Patients with Type 1 Diabetes**: This combination is not suitable for people with type 1 diabetes, as it is intended for type 2 diabetes management. 4. **Pregnant or Breastfeeding Women**: The safety of this combination during pregnancy or breastfeeding is not well established, so it should be avoided unless specifically advised by a healthcare provider. 5. **People with Allergies to the Ingredients**: Anyone who has had an allergic reaction to Dapagliflozin, Saxagliptin, or any of their components should not take this combination. Always consult with a healthcare professional before starting or stopping any medication.
Who should avoid taking combination of Saxagliptin and Dapagliflozin?
Important warnings for Saxagliptin include the risk of pancreatitis and heart failure, while Dapagliflozin carries warnings for dehydration, urinary tract infections, and ketoacidosis. Both medications are contraindicated in patients with severe renal impairment and those with a history of serious hypersensitivity reactions to the drugs. Patients should be aware of the symptoms of these conditions and seek medical attention if they occur. Regular monitoring and communication with a healthcare provider are essential to manage these risks effectively.
