Dantrolene
Multiple Sclerosis, Cerebral Palsy ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Skeletal Muscle Relaxant
Controlled Drug Substance
No
Dantrolene
Summary
Dantrolene is used to treat muscle spasticity associated with conditions like spinal cord injuries, stroke, multiple sclerosis, and cerebral palsy. It is also used to prevent and treat malignant hyperthermia, a serious condition that causes a rapid rise in body temperature and severe muscle contractions.
Dantrolene works by relaxing skeletal muscles. It interferes with the release of calcium from the sarcoplasmic reticulum in muscle cells, which reduces muscle contractions. This helps alleviate muscle stiffness and spasms associated with various conditions.
For adults, the usual dosage for chronic spasticity starts at 25 mg once daily, gradually increasing to 100 mg three times a day if needed. For children, the dosage starts at 0.5 mg/kg once daily, increasing to 2 mg/kg three times a day if necessary. Always follow your doctor's instructions.
Common side effects of Dantrolene include drowsiness, dizziness, muscle weakness, and diarrhea. Serious adverse effects include liver damage, seizures, and difficulty breathing. If you experience any severe side effects, contact your doctor immediately.
Dantrolene can cause severe liver damage, so it should not be used in patients with liver disease. Regular liver function tests are recommended. It may cause drowsiness and dizziness, affecting the ability to drive. Avoid alcohol as it can worsen side effects.
Indications and Purpose
How does Dantrolene work?
Dantrolene works by interfering with the release of calcium in muscle cells, which reduces muscle contractions. Think of it like turning down the volume on a radio to reduce noise. This action helps relax the muscles, improving mobility and reducing discomfort. Dantrolene is effective for conditions like muscle spasticity and malignant hyperthermia.
Is Dantrolene effective?
Dantrolene is effective for treating muscle spasticity, which is a condition where muscles are continuously contracted, causing stiffness or tightness. It works by relaxing the muscles, improving mobility and reducing discomfort. Clinical studies support its effectiveness in managing conditions like multiple sclerosis and cerebral palsy. Always follow your doctor's instructions for the best results.
What is Dantrolene?
Dantrolene is a muscle relaxant used to treat muscle spasticity, which is a condition where muscles are continuously contracted, causing stiffness or tightness. It works by relaxing the muscles, improving mobility and reducing discomfort. Dantrolene is also used to treat a rare condition called malignant hyperthermia, which is a severe reaction to certain drugs used during surgery.
Directions for Use
For how long do I take Dantrolene?
Dantrolene is usually taken long-term for managing chronic conditions like muscle spasticity. The duration of use depends on your response to the medication and any side effects you experience. Always follow your doctor's instructions and talk with them before changing or stopping your Dantrolene treatment.
How do I dispose of Dantrolene?
Dispose of Dantrolene by taking it to a drug take-back program or collection site at a pharmacy or hospital. If that's not possible, mix the medication with an undesirable substance like used coffee grounds, seal it in a plastic bag, and throw it away in the trash. This helps prevent harm to people and the environment.
How do I take Dantrolene?
Take Dantrolene exactly as prescribed by your doctor. It's usually taken once daily, with or without food. You can crush the tablet if needed. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose. Don't take two doses at once. Avoid alcohol while on this medication, as it can increase certain risks. Always follow your doctor's specific advice about diet and fluid intake.
How long does it take for Dantrolene to start working?
Dantrolene begins working in your body shortly after you take it, but the full effects may take a few days to become noticeable. The time it takes to achieve its full therapeutic effect can vary based on individual factors like your condition and overall health. Always take Dantrolene as prescribed for the best results.
How should I store Dantrolene?
Store Dantrolene at room temperature, away from moisture and light. Keep it in a tightly closed container. Avoid storing it in humid places like bathrooms. Always keep Dantrolene out of children's reach to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Dantrolene?
The usual starting dose of Dantrolene for adults is typically determined by your doctor based on your specific condition. It's important to follow your doctor's dosing instructions carefully. The dose may be adjusted based on your response to the medication. Always consult your doctor for personalized dosing information.
Warnings and Precautions
Can Dantrolene be taken safely while breastfeeding?
Dantrolene is not recommended while breastfeeding. Limited information is available on whether it passes into breast milk. If you're taking Dantrolene and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Dantrolene be taken safely while pregnant?
Dantrolene is not recommended during pregnancy unless absolutely necessary. Limited data is available on its safety in pregnant women. Animal studies suggest potential risks to the fetus. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options for your condition.
Can I take Dantrolene with other prescription drugs?
Dantrolene can interact with certain medications, increasing the risk of side effects. For example, combining it with other muscle relaxants or sedatives can enhance drowsiness. It's important to inform your doctor about all medications you're taking to avoid potential interactions. Your doctor can provide guidance on safe medication combinations.
Does Dantrolene have adverse effects?
Adverse effects are unwanted reactions to a medication. Dantrolene can cause side effects like drowsiness, dizziness, and muscle weakness. These effects vary in frequency and severity. Serious side effects include liver damage, which requires immediate medical attention. Always inform your doctor about any new or worsening symptoms while taking Dantrolene.
Does Dantrolene have any safety warnings?
Yes, Dantrolene has important safety warnings. It can cause liver damage, so regular liver function tests are recommended. Symptoms like nausea, vomiting, or jaundice, which is yellowing of the skin or eyes, require immediate medical attention. Dantrolene can also cause muscle weakness, so be cautious if you need to perform tasks requiring strength. Always follow your doctor's instructions and report any unusual symptoms.
Is Dantrolene addictive?
Dantrolene is not considered addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Dantrolene works by affecting muscle function and doesn't impact brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, you can feel confident that Dantrolene doesn't carry this risk.
Is Dantrolene safe for the elderly?
Elderly individuals may be more vulnerable to the side effects of Dantrolene, such as liver damage and muscle weakness. It's important for older adults to be closely monitored by their doctor while taking this medication. Dose adjustments may be necessary to ensure safety and effectiveness.
Is it safe to drink alcohol while taking Dantrolene?
It's best to avoid alcohol while taking Dantrolene. Alcohol can increase the risk of liver damage and enhance side effects like dizziness and drowsiness. If you choose to drink occasionally, limit your alcohol intake and watch for any warning signs. Talk with your doctor about alcohol use while taking Dantrolene for personalized advice.
Is it safe to exercise while taking Dantrolene?
You can exercise while taking Dantrolene, but be cautious. Dantrolene can cause muscle weakness and dizziness, which might affect your ability to exercise safely. Drink plenty of water before, during, and after physical activity. If you notice dizziness or unusual fatigue, slow down or stop exercising and rest. Consult your doctor if you have concerns.
Is it safe to stop Dantrolene?
It's important to consult your doctor before stopping Dantrolene. Stopping suddenly can cause your symptoms to return or worsen. Your doctor might suggest gradually reducing your dose to avoid any potential issues. Always follow your doctor's guidance to ensure safe discontinuation of the medication.
What are the most common side effects of Dantrolene?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Dantrolene include drowsiness, dizziness, and muscle weakness. These effects vary from person to person. If you notice new symptoms after starting Dantrolene, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Dantrolene?
Dantrolene should not be used if you have liver disease, as it can cause liver damage. It's also contraindicated in people with a known allergy to Dantrolene. Use caution if you have heart or lung problems, as Dantrolene can affect these systems. Always consult your doctor about your medical history before starting Dantrolene.
