Dacomitinib
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
dacomitinib
Summary
Dacomitinib is used to treat non-small cell lung cancer, which is a type of lung cancer. It helps slow the progression of the disease by blocking proteins that promote cancer cell growth. Dacomitinib is typically used as a long-term treatment to manage cancer and improve survival.
Dacomitinib works by blocking certain proteins called tyrosine kinases, which help cancer cells grow and spread. Think of it like turning off a switch that powers cancer cell growth. By inhibiting these proteins, Dacomitinib slows down the progression of non-small cell lung cancer, helping to control the disease and improve survival.
The usual starting dose of Dacomitinib for adults is 45 mg once daily. Your doctor may adjust your dose based on your response and any side effects. Always follow your doctor's specific dosing instructions for your personal health needs. If you have any concerns about your dose, discuss them with your healthcare provider.
Common side effects of Dacomitinib include diarrhea, rash, and mouth sores. These effects vary from person to person. If you notice new symptoms after starting Dacomitinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Dacomitinib has important safety warnings. It can cause serious lung problems, such as interstitial lung disease, which is inflammation and scarring of the lung tissue. If you experience new or worsening cough, shortness of breath, or difficulty breathing, contact your doctor immediately. Dacomitinib can also cause severe diarrhea, which may lead to dehydration.
Indications and Purpose
How does Dacomitinib work?
Dacomitinib works by blocking certain proteins called tyrosine kinases, which help cancer cells grow and spread. Think of it like turning off a switch that powers cancer cell growth. By inhibiting these proteins, Dacomitinib slows down the progression of non-small cell lung cancer, helping to control the disease and improve survival. This mechanism makes it an effective treatment option for patients with this type of cancer.
Is Dacomitinib effective?
Dacomitinib is effective for treating non-small cell lung cancer, which is a type of lung cancer. It works by blocking certain proteins that help cancer cells grow. Clinical studies show Dacomitinib can improve progression-free survival, which is the length of time during and after treatment that a patient lives with the disease without it getting worse. Your doctor will monitor your response to the medication to ensure it's working effectively for you.
What is Dacomitinib?
Dacomitinib is a medication used to treat non-small cell lung cancer, which is a type of lung cancer. It belongs to a class of drugs called tyrosine kinase inhibitors, which work by blocking certain proteins that help cancer cells grow. Dacomitinib is used to slow the progression of cancer and improve survival in patients with this condition. It is usually prescribed as a long-term treatment.
Directions for Use
For how long do I take Dacomitinib?
Dacomitinib is usually a long-term medication for managing non-small cell lung cancer. You'll typically take it every day as prescribed by your doctor. The duration of use depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Dacomitinib treatment.
How do I dispose of Dacomitinib?
Dispose of unused Dacomitinib by taking it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Dacomitinib?
Take Dacomitinib as prescribed by your doctor, usually once daily. You can take it with or without food. Do not crush or chew the tablet. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Avoid taking two doses at once. Follow your doctor's specific advice about diet and fluid intake while taking this medication.
How long does it take for Dacomitinib to start working?
Dacomitinib starts working in your body shortly after you take it, but the full therapeutic effects may take several weeks to become noticeable. The time it takes to see results can vary depending on individual factors like your overall health and how your body responds to the medication. Regular check-ups with your doctor are important to monitor your progress and adjust your treatment as needed.
How should I store Dacomitinib?
Store Dacomitinib at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms, where moisture could affect how well the medication works. Always store Dacomitinib out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Dacomitinib?
The usual starting dose of Dacomitinib for adults is 45 mg once daily. Your doctor may adjust your dose based on your response and any side effects. Always follow your doctor's specific dosing instructions for your personal health needs. If you have any concerns about your dose, discuss them with your healthcare provider.
Warnings and Precautions
Can Dacomitinib be taken safely while breastfeeding?
Dacomitinib is not recommended while breastfeeding. There is limited information on whether it passes into human breast milk, but it may pose risks to a nursing infant. If you're taking Dacomitinib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Dacomitinib be taken safely while pregnant?
Dacomitinib is not recommended during pregnancy. There is limited information on its safety in pregnant women, and it may harm an unborn baby. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take Dacomitinib with other prescription drugs?
Dacomitinib can interact with medications that affect stomach acid, such as proton pump inhibitors and H2-receptor antagonists. It can also increase the concentration of drugs metabolized by CYP2D6, potentially leading to increased side effects. Always inform your doctor of all medications you are taking.
Does Dacomitinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Dacomitinib include diarrhea, rash, and mouth sores. These effects vary in frequency and severity. Serious side effects can include lung problems and severe diarrhea. If you experience any new or worsening symptoms, contact your doctor. They can help determine if these symptoms are related to Dacomitinib and recommend appropriate actions.
Does Dacomitinib have any safety warnings?
Yes, Dacomitinib has important safety warnings. It can cause serious lung problems, such as interstitial lung disease, which is inflammation and scarring of the lung tissue. If you experience new or worsening cough, shortness of breath, or difficulty breathing, contact your doctor immediately. Dacomitinib can also cause severe diarrhea, which may lead to dehydration. Drink plenty of fluids and inform your doctor if you experience severe or persistent diarrhea. Always follow your doctor's advice and report any new or worsening symptoms.
Is Dacomitinib addictive?
Dacomitinib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Dacomitinib works by targeting specific proteins in cancer cells, and this mechanism doesn't affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, you can feel confident that Dacomitinib doesn't carry this risk.
Is Dacomitinib safe for the elderly?
Elderly patients (65 years and older) may experience a higher incidence of severe side effects, more frequent dose interruptions, and more frequent discontinuations of Dacomitinib. It is important for elderly patients to be closely monitored by their healthcare provider to manage any adverse reactions effectively.
Is it safe to drink alcohol while taking Dacomitinib?
It's best to avoid alcohol while taking Dacomitinib. Alcohol can worsen side effects like dehydration and liver problems. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like nausea or dizziness. Talk with your doctor about alcohol use while taking Dacomitinib to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Dacomitinib?
You can exercise while taking Dacomitinib, but be cautious. This medication can cause side effects like fatigue and dehydration, which might affect your exercise capacity. To exercise safely, drink plenty of water before, during, and after physical activity. Watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest. Check with your doctor if you have concerns about your specific situation.
Is it safe to stop Dacomitinib?
Stopping Dacomitinib suddenly can affect your treatment. If you're taking it for cancer, stopping could allow the cancer to progress. Always talk with your doctor before stopping Dacomitinib. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
What are the most common side effects of Dacomitinib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Dacomitinib include diarrhea, rash, and mouth sores. These effects vary from person to person. If you notice new symptoms after starting Dacomitinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Dacomitinib?
Dacomitinib should not be used if you are allergic to it or any of its ingredients. Serious allergic reactions, which cause rash, hives, or swelling that makes breathing difficult, require immediate medical help. Always inform your doctor about any allergies you have. Your doctor will assess the risks and benefits before prescribing Dacomitinib.
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