Dabrafenib
Melanoma
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
dabrafenib
Summary
Dabrafenib is used to treat certain types of cancer, such as melanoma, which is a skin cancer, with a specific BRAF mutation, which is a change in a gene that can lead to cancer growth.
Dabrafenib works by blocking the activity of a protein called BRAF, which is involved in cell growth. In certain cancers, BRAF is mutated and overactive, leading to uncontrolled cell growth. Dabrafenib inhibits this process, helping to slow or stop cancer progression.
The usual starting dose of Dabrafenib for adults is 150 mg taken twice daily. It is taken orally, which means by mouth, usually on an empty stomach, at least 1 hour before or 2 hours after a meal.
Common side effects of Dabrafenib include skin rashes, fever, and fatigue, which means feeling very tired. These effects vary from person to person and should be discussed with a doctor if they occur.
Dabrafenib can increase the risk of new skin cancers and may cause serious bleeding, fever, or heart problems. It is not recommended for use in patients with severe liver problems or during pregnancy, which is the period when a woman carries a developing fetus.
Indications and Purpose
How does Dabrafenib work?
Dabrafenib works by blocking the activity of a protein called BRAF, which is involved in cell growth. In certain cancers, BRAF is mutated and overactive, leading to uncontrolled cell growth. Dabrafenib inhibits this process, helping to slow or stop cancer progression. It's like turning off a switch that keeps cancer cells growing.
Is Dabrafenib effective?
Dabrafenib is effective in treating certain types of cancer, such as melanoma with a specific BRAF mutation. It works by blocking the activity of the BRAF protein, which helps stop cancer cell growth. Clinical studies show Dabrafenib can improve survival rates and reduce tumor size in patients with this mutation.
What is Dabrafenib?
Dabrafenib is a medication used to treat certain types of cancer, such as melanoma with a specific BRAF mutation. It belongs to a class of drugs called kinase inhibitors, which work by blocking the activity of proteins that promote cancer cell growth. Dabrafenib is often used in combination with other therapies to enhance its effectiveness.
Directions for Use
For how long do I take Dabrafenib?
Dabrafenib is usually a long-term medication for managing certain cancers. You'll typically take it every day as prescribed by your doctor. How long you'll need this medication depends on your body's response and any side effects. Always talk with your doctor before changing or stopping your Dabrafenib treatment.
How do I dispose of Dabrafenib?
Dispose of Dabrafenib by taking it to a drug take-back program or collection site at a pharmacy or hospital. If unavailable, mix it with undesirable substances like used coffee grounds, seal in a plastic bag, and throw it away. This prevents harm to people and the environment.
How do I take Dabrafenib?
Take Dabrafenib as prescribed by your doctor, usually twice daily, about 12 hours apart. It's best taken on an empty stomach, at least 1 hour before or 2 hours after a meal. Swallow the capsules whole; do not crush or open them. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose. Do not double up on doses.
How long does it take for Dabrafenib to start working?
Dabrafenib starts working in your body shortly after you take it, but noticeable effects may take weeks. The time it takes to achieve full therapeutic effect varies based on individual factors like your cancer type and overall health. Regular check-ups and tests help monitor its effectiveness. Follow your doctor's instructions for the best results.
How should I store Dabrafenib?
Store Dabrafenib at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms. If your pills came in packaging that isn't child-resistant, transfer them to a container that children can't easily open. Always store Dabrafenib out of children's reach.
What is the usual dose of Dabrafenib?
The usual starting dose of Dabrafenib for adults is 150 mg taken twice daily. Your doctor may adjust the dose based on your response and any side effects. It's important to follow your doctor's specific dosing instructions. Dabrafenib is not typically used in children or the elderly without careful monitoring.
Warnings and Precautions
Can Dabrafenib be taken safely while breastfeeding?
Dabrafenib is not recommended while breastfeeding. We don't have much information about whether it passes into human breast milk, but it could pose risks to a baby's developing organs. If you're taking Dabrafenib and want to breastfeed, talk with your doctor about safer medication options.
Can Dabrafenib be taken safely while pregnant?
Dabrafenib is not recommended during pregnancy. It can harm an unborn baby. We don't have much information about its use in pregnant women, but animal studies show potential risks. If you're pregnant or planning to become pregnant, talk with your doctor about safer treatment options.
Can I take Dabrafenib with other prescription drugs?
Dabrafenib can interact with strong inhibitors or inducers of CYP3A4 and CYP2C8, which may affect its concentration in the body. It can also decrease the effectiveness of hormonal contraceptives and other medications metabolized by these enzymes. Patients should inform their doctor of all medications they are taking to avoid potential interactions.
Does Dabrafenib have adverse effects?
Adverse effects are unwanted reactions to a medication. Dabrafenib can cause side effects like skin rashes, fever, and fatigue. Serious effects include new skin cancers and heart problems. If you notice any new or worsening symptoms, contact your doctor immediately. They can help determine if these are related to Dabrafenib and suggest appropriate actions.
Does Dabrafenib have any safety warnings?
Yes, Dabrafenib has important safety warnings. It can increase the risk of new skin cancers, so regular skin checks are important. It may also cause serious bleeding, fever, or heart problems. Not following these warnings can lead to severe health issues. Always discuss any concerns with your doctor and follow their advice closely.
Is Dabrafenib addictive?
Dabrafenib is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. This medication works by targeting specific proteins in cancer cells and doesn't affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, discuss them with your doctor.
Is Dabrafenib safe for the elderly?
In clinical studies, no overall differences in the effectiveness or safety of Dabrafenib were observed between elderly patients and younger adults. However, elderly patients may experience more serious adverse reactions and may require more frequent dose adjustments. It's important for elderly patients to be closely monitored by their healthcare provider while taking Dabrafenib.
Is it safe to drink alcohol while taking Dabrafenib?
It's best to avoid alcohol while taking Dabrafenib. Alcohol can increase the risk of liver problems and dehydration, which may worsen side effects like dizziness. If you choose to drink, limit your intake and watch for warning signs like nausea or dizziness. Talk with your doctor about alcohol use while on Dabrafenib.
Is it safe to exercise while taking Dabrafenib?
You can exercise while taking Dabrafenib, but be cautious. This medication can cause fatigue and dizziness, which might affect your exercise capacity. To exercise safely, stay hydrated and watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest.
Is it safe to stop Dabrafenib?
Stopping Dabrafenib suddenly can affect your treatment. It's used for long-term management of certain cancers. Stopping without medical advice could worsen your condition. Always talk with your doctor before stopping Dabrafenib. They might suggest a gradual reduction or alternative treatment to keep your condition under control.
What are the most common side effects of Dabrafenib?
Side effects are unwanted reactions to a medication. Common side effects of Dabrafenib include skin rashes, fever, and fatigue. These effects vary from person to person. If you notice new symptoms after starting Dabrafenib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Dabrafenib?
Don't take Dabrafenib if you're allergic to it or its ingredients. It's not for use in patients with severe liver problems. Caution is needed if you have heart issues or are pregnant. Always consult your doctor about these concerns to ensure Dabrafenib is safe for you.
