Cyclosporine
Focal Segmental Glomerulosclerosis, Rheumatoid Arthritis ... show more
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Possible
Pharmaceutical Class
Calcineurin Inhibitor Immunosuppressant
Controlled Drug Substance
NO
Cyclosporine
Learn more about this medicine -
Click HereSummary
Cyclosporine is used primarily to prevent organ rejection after a transplant. It's also used to treat autoimmune conditions like rheumatoid arthritis, psoriasis, and certain conditions like nephrotic syndrome.
Cyclosporine works by suppressing your immune system. It inhibits specific immune cells called T-cells, preventing them from attacking foreign tissues in transplants or causing inflammation in autoimmune diseases.
Cyclosporine is usually taken orally, either as a capsule or liquid, once or twice a day. For organ transplants, the usual adult dose is 5-10 mg/kg daily, divided into two doses. For autoimmune diseases, doses can range from 2.5 mg/kg to 5 mg/kg per day.
Common side effects of Cyclosporine include kidney damage, high blood pressure, increased hair growth, nausea, and tremors. Some people may experience mood swings, changes in appetite, or sleep problems.
Cyclosporine should be avoided by people with active infections, uncontrolled hypertension, or kidney problems. It's not recommended for pregnant women or those planning pregnancy, and it's excreted in breast milk, so breastfeeding while on this medication is not advised.
Indications and Purpose
How does Cyclosporine work?
Cyclosporine works by inhibiting the action of specific immune cells (T-cells), preventing them from attacking foreign tissues in the case of a transplant or stopping them from causing inflammation in autoimmune diseases.
How does one know if Cyclosporine is working?
For transplants, regular blood tests and monitoring by a healthcare provider will indicate how well cyclosporine is working. For autoimmune diseases, improved symptoms such as reduced inflammation, pain, or skin condition indicate effectiveness.
Is Cyclosporine effective?
Yes, cyclosporine is proven to be highly effective in preventing organ rejection after transplant and managing symptoms of autoimmune diseases by suppressing the immune system.
What is Cyclosporine?
Cyclosporine is an immunosuppressive medication used to prevent organ rejection after a transplant and to treat autoimmune conditions such as rheumatoid arthritis and psoriasis. It works by suppressing the immune system to prevent it from attacking the transplanted organ or causing inflammation in autoimmune diseases.
What is Cyclosporine used for?
Cyclosporine is used to prevent rejection in organ transplant patients and treat autoimmune diseases such as rheumatoid arthritis, psoriasis, and certain conditions like nephrotic syndrome.
Directions for Use
For how long do I take Cyclosporine?
Cyclosporine is typically taken for the long-term, especially for organ transplant patients to prevent rejection. For autoimmune conditions, the duration varies depending on response and doctor's recommendations.
How do I take Cyclosporine?
Cyclosporine should be taken orally in the form of a capsule or liquid, usually once or twice a day. It can be taken with or without food. Make sure to take it at the same time each day to maintain consistent blood levels.
How long does it take for Cyclosporine to start working?
It may take several weeks for cyclosporine to start working. In organ transplant cases, it helps prevent rejection immediately after surgery, while autoimmune conditions may take longer to show improvement.
How should I store Cyclosporine?
Store cyclosporine at room temperature, away from direct sunlight and moisture. Keep it in the original container to protect it from light and keep it out of the reach of children.
What is the usual dose of Cyclosporine?
The usual adult dose for organ transplant is 5–10 mg/kg daily, divided into two doses. For autoimmune diseases, doses can range from 2.5 mg/kg to 5 mg/kg per day. Dosages depend on individual factors such as weight and the specific condition.
Warnings and Precautions
Can Cyclosporine be taken safely while breastfeeding?
Cyclosporine is excreted in breast milk, so it is not recommended for breastfeeding. Consult your doctor for advice on whether to breastfeed while taking this medication.
Can Cyclosporine be taken safely while pregnant?
Cyclosporine may harm the unborn baby and should only be taken during pregnancy if necessary. Talk to your doctor if you are pregnant or planning to become pregnant while taking cyclosporine.
Can I take Cyclosporine with other prescription drugs?
Cyclosporine interacts with numerous medications such as certain antifungals, antibiotics, blood pressure medications, and statins. Discuss all other medications with your healthcare provider to avoid potential interactions.
Can I take Cyclosporine with vitamins or supplements?
Cyclosporine can interact with some vitamins or supplements, particularly those affecting liver enzymes (like St. John's Wort) or certain minerals (like potassium). Consult your doctor before taking any supplements.
Is Cyclosporine safe for the elderly?
Elderly people may be more sensitive to the effects of cyclosporine, especially its impact on kidney function. They may require closer monitoring and lower doses. Always discuss with the doctor before starting treatment.
Is it safe to drink alcohol while taking Cyclosporine?
Drinking alcohol with cyclosporine can increase the risk of liver damage, kidney issues, or interfere with its effectiveness. It’s advisable to limit or avoid alcohol consumption while taking this medication.
Is it safe to exercise while taking Cyclosporine?
Moderate exercise is generally safe while on cyclosporine, but be mindful of overexertion, as cyclosporine can increase your risk of dehydration and muscle cramps. Stay well-hydrated and consult your doctor if unsure.
Who should avoid taking Cyclosporine?
People with active infections, uncontrolled hypertension, kidney problems, or those who are allergic to cyclosporine should avoid it. Pregnant women or those planning pregnancy should consult their doctor.
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