Crofelemer
Diarrhea
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Antidiarrheal
Controlled Drug Substance
No
crofelemer
Summary
Crofelemer is used to treat diarrhea in people with HIV/AIDS who are on antiretroviral therapy, which is a treatment that uses drugs to control HIV infection. It helps manage symptoms and improve the quality of life for those affected.
Crofelemer works by normalizing the flow of chloride ions, which are particles that carry an electric charge, in the intestines. This helps reduce diarrhea by maintaining the right balance of fluids in the intestines, similar to adjusting a faucet to control water flow.
The usual dose of Crofelemer for adults is 125 mg taken twice daily. It can be taken with or without food. Always follow your doctor's specific dosing instructions for your personal health needs.
Common side effects of Crofelemer include upper respiratory tract infections, which affect the nose and throat, and bronchitis, which is inflammation of the airways. These occur in a small percentage of people taking this medication.
Crofelemer should not be used if you are allergic to it or any of its ingredients. Serious allergic reactions require immediate medical help. Always inform your doctor about any allergies you have before starting Crofelemer.
Indications and Purpose
How does Crofelemer work?
Crofelemer works by normalizing the flow of chloride ions in the intestines, which helps reduce diarrhea. Think of it like adjusting a faucet to control water flow. By regulating chloride flow, Crofelemer helps maintain the right balance of fluids in the intestines, reducing diarrhea. This makes it effective for managing diarrhea in people with HIV/AIDS on antiretroviral therapy.
Is Crofelemer effective?
Yes, Crofelemer is effective for treating diarrhea in people with HIV/AIDS on antiretroviral therapy. It works by normalizing the flow of chloride ions in the intestines, which helps reduce diarrhea. Clinical studies have shown that Crofelemer significantly reduces the frequency of diarrhea in affected individuals, improving their quality of life.
What is Crofelemer?
Crofelemer is a medication used to treat diarrhea in people with HIV/AIDS on antiretroviral therapy. It belongs to a class of medicines called anti-diarrheals. Crofelemer works by normalizing the flow of chloride ions in the intestines, which helps reduce diarrhea. It's used as a complementary treatment to manage symptoms and improve quality of life.
Directions for Use
For how long do I take Crofelemer?
Crofelemer is usually taken long-term for managing diarrhea in people with HIV/AIDS on antiretroviral therapy. The duration of use depends on your condition and how well you respond to the medication. Always follow your doctor's instructions and talk with them before making any changes to your treatment plan.
How do I dispose of Crofelemer?
Dispose of Crofelemer by taking it to a drug take-back program or collection site at a pharmacy or hospital. If that's not possible, mix the medication with an undesirable substance like used coffee grounds, seal it in a plastic bag, and throw it away in the trash. This helps prevent harm to people and the environment.
How do I take Crofelemer?
Take Crofelemer as directed by your doctor. It's usually taken twice daily, with or without food. Swallow the tablets whole; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific instructions.
How long does it take for Crofelemer to start working?
Crofelemer begins working in your body shortly after you take it. You may start to notice a reduction in diarrhea within a few days. However, the full therapeutic effect may take a couple of weeks. Individual factors like your overall health and the severity of your symptoms can affect how quickly you see results. Follow your doctor's instructions for the best outcome.
How should I store Crofelemer?
Store Crofelemer at room temperature, away from moisture and light. Keep it in its original container with the lid tightly closed. Do not store it in the bathroom, where humidity can affect the medication. Always keep Crofelemer out of reach of children and pets. Check the expiration date regularly and dispose of any expired medication properly.
What is the usual dose of Crofelemer?
The usual dose of Crofelemer for adults is 125 mg taken twice daily. This dose is typically taken with or without food. Always follow your doctor's specific dosing instructions for your personal health needs. If you have any questions about your dose, consult your healthcare provider.
Warnings and Precautions
Can Crofelemer be taken safely while breastfeeding?
The safety of Crofelemer while breastfeeding is not well-established. It's unclear if the medication passes into breast milk. If you're breastfeeding or planning to breastfeed, talk with your doctor about the safest treatment options. Your doctor can help determine the best approach for managing your condition while ensuring your baby's safety.
Can Crofelemer be taken safely while pregnant?
The safety of Crofelemer during pregnancy is not well-established. There is limited information on its use in pregnant women. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options for managing your condition. Your doctor can help create a plan that protects both you and your baby.
Can I take Crofelemer with other prescription drugs?
Crofelemer does not have clinically relevant interactions with nelfinavir, zidovudine, or lamivudine. However, it has the potential to inhibit certain transporters in the gut. Patients should inform their doctor of all medications they are taking to avoid potential interactions.
Does Crofelemer have adverse effects?
Adverse effects are unwanted reactions to a medication. With Crofelemer, common adverse effects include upper respiratory tract infections and bronchitis. These occur in a small percentage of users. Serious side effects are rare but can include severe diarrhea or allergic reactions. If you notice any new or worsening symptoms, contact your doctor immediately.
Does Crofelemer have any safety warnings?
Yes, Crofelemer has safety warnings. It's important to take it as prescribed to avoid potential side effects. If you experience severe diarrhea, dehydration, or any allergic reactions, seek medical attention immediately. Not adhering to safety warnings can lead to complications, so always follow your doctor's advice and report any unusual symptoms.
Is Crofelemer addictive?
No, Crofelemer is not addictive or habit-forming. It doesn't cause dependency or withdrawal symptoms when you stop taking it. Crofelemer works by affecting the intestines to help manage diarrhea, and this mechanism doesn't lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed.
Is Crofelemer safe for the elderly?
Clinical studies with Crofelemer did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently than younger patients. Therefore, elderly patients should use Crofelemer with caution and under the guidance of a healthcare provider.
Is it safe to drink alcohol while taking Crofelemer?
There are no well-established interactions between Crofelemer and alcohol. However, it's generally a good idea to limit alcohol consumption while taking any medication. Alcohol can cause dehydration, which might worsen diarrhea. If you choose to drink, do so in moderation and stay hydrated. Talk with your doctor for personalized advice.
Is it safe to exercise while taking Crofelemer?
Yes, it's safe to exercise while taking Crofelemer. This medication doesn't typically limit exercise capacity. However, if you experience diarrhea, stay hydrated during physical activity to prevent dehydration. If you notice any unusual symptoms during exercise, such as dizziness or fatigue, slow down or stop and rest. Consult your doctor if you have concerns.
Is it safe to stop Crofelemer?
Yes, it's generally safe to stop Crofelemer, but always consult your doctor first. Crofelemer is used for managing diarrhea in certain conditions, and stopping it might cause symptoms to return. There are no known withdrawal symptoms, but your doctor can guide you on how to stop safely and discuss alternative treatments if needed.
What are the most common side effects of Crofelemer?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Crofelemer include upper respiratory tract infections and bronchitis. These occur in a small percentage of people taking this medication. If you notice new symptoms after starting Crofelemer, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Crofelemer?
Crofelemer should not be used if you are allergic to it or any of its ingredients. Serious allergic reactions require immediate medical help. Always inform your doctor about any allergies you have. There are no specific contraindications related to other medical conditions, but always consult your doctor before starting Crofelemer.
