Crizotinib
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
crizotinib
Summary
Crizotinib is used to treat non-small cell lung cancer, which is a type of cancer affecting the lungs, with specific genetic mutations. These mutations make the cancer cells grow and spread, and Crizotinib helps to slow or stop this process.
Crizotinib works by blocking proteins called tyrosine kinases, which help cancer cells grow and spread. By turning off these proteins, Crizotinib can slow or stop the growth of cancer cells, making it effective for certain genetic mutations.
The usual starting dose of Crizotinib for adults is 250 mg taken orally twice daily. It is important to follow your doctor's instructions and not to crush or chew the capsules. The dose may be adjusted based on your response and any side effects.
Common side effects of Crizotinib include nausea, diarrhea, and vision changes. These effects can vary in frequency and severity among patients. If you experience any new or worsening symptoms, it's important to contact your doctor.
Crizotinib can cause liver problems, vision issues, and heart rhythm changes. It is not recommended for people with severe liver problems or those who are pregnant. Regular monitoring is important, and any unusual symptoms should be reported to your doctor immediately.
Indications and Purpose
How does Crizotinib work?
Crizotinib works by blocking certain proteins called tyrosine kinases, which help cancer cells grow and spread. Think of it like turning off a switch that powers cancer cell growth. By inhibiting these proteins, Crizotinib can slow or stop the growth of cancer cells. This action makes it effective for treating cancers with specific genetic mutations, such as non-small cell lung cancer. Your doctor will monitor your response to ensure the medication is working effectively.
Is Crizotinib effective?
Crizotinib is effective for treating certain types of cancer, such as non-small cell lung cancer with specific genetic mutations. Clinical studies show that Crizotinib can shrink tumors and slow cancer progression. It works by blocking proteins that help cancer cells grow. The effectiveness of Crizotinib can vary based on individual factors, such as the specific genetic makeup of the cancer. Your doctor will monitor your response to the medication to ensure it's working effectively for you.
What is Crizotinib?
Crizotinib is a medication used to treat certain types of cancer, such as non-small cell lung cancer with specific genetic mutations. It belongs to a class of drugs called tyrosine kinase inhibitors, which block proteins that help cancer cells grow. By targeting these proteins, Crizotinib can slow or stop the growth of cancer cells. It's used alone or in combination with other therapies, depending on the specific cancer type and stage.
Directions for Use
For how long do I take Crizotinib?
Crizotinib is usually taken long-term for managing certain types of cancer, like non-small cell lung cancer. The duration of use depends on your response to the medication and any side effects you experience. Your doctor will monitor your condition and adjust your treatment as needed. Always talk with your doctor before changing or stopping your Crizotinib treatment to ensure your health condition remains under control.
How do I dispose of Crizotinib?
Dispose of unused Crizotinib by taking it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away. Always keep medications out of reach of children and pets.
How do I take Crizotinib?
Take Crizotinib exactly as your doctor prescribes. It's usually taken twice daily, with or without food. Swallow the capsules whole; do not crush or chew them. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose. Do not take two doses at once. Avoid grapefruit and grapefruit juice while taking Crizotinib, as they can affect how the medicine works. Always follow your doctor's specific instructions regarding your medication.
How long does it take for Crizotinib to start working?
Crizotinib begins working in your body shortly after you take it, but the full therapeutic effect may take several weeks. The time it takes to see noticeable benefits can vary based on individual factors, such as the specific type of cancer and your overall health. Regular monitoring by your doctor will help assess how well Crizotinib is working for you. Always take it exactly as prescribed for the best results.
How should I store Crizotinib?
Store Crizotinib at room temperature, away from moisture and light. Keep it in a tightly closed container. Do not store it in humid places like bathrooms, as moisture can affect the medication's effectiveness. Always keep Crizotinib out of reach of children and pets. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Crizotinib?
The usual starting dose of Crizotinib for adults is 250 mg taken orally twice daily. Your doctor may adjust the dose based on your response and any side effects. It's important to follow your doctor's dosing instructions carefully. The maximum recommended dose is typically 250 mg twice daily. Dose adjustments may be necessary for special populations, such as those with liver or kidney issues. Always consult your doctor for personalized dosing guidance.
Warnings and Precautions
Can Crizotinib be taken safely while breastfeeding?
Crizotinib is not recommended while breastfeeding. We don't have much information about whether it passes into human breast milk. However, it could potentially affect a baby's development. If you're taking Crizotinib and want to breastfeed, talk with your doctor about safer medication options. They can help you find a treatment that allows you to nurse your baby safely.
Can Crizotinib be taken safely while pregnant?
Crizotinib is not recommended during pregnancy due to potential risks to the unborn baby. Animal studies suggest it may harm fetal development. We have limited information about its use in pregnant women. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options. Your doctor can help create a pregnancy-specific plan that protects both you and your baby.
Can I take Crizotinib with other prescription drugs?
Crizotinib can interact with certain medications, increasing the risk of side effects or reducing effectiveness. For example, drugs that affect liver enzymes, like certain antifungals or antibiotics, can alter Crizotinib levels in your body. Always inform your doctor about all medications you're taking to avoid potential interactions. Your doctor can adjust your treatment plan to ensure safety and effectiveness.
Does Crizotinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Crizotinib include nausea, diarrhea, and vision changes. These effects vary in frequency and severity. Serious side effects can include liver problems and heart rhythm changes. If you notice any new or worsening symptoms, contact your doctor immediately. They can help determine if these symptoms are related to Crizotinib and provide appropriate care.
Does Crizotinib have any safety warnings?
Yes, Crizotinib has important safety warnings. It can cause liver problems, vision issues, and heart rhythm changes. Regular monitoring of liver function and heart health is recommended. If you experience symptoms like yellowing of the skin, vision changes, or irregular heartbeat, seek medical attention immediately. Not adhering to these warnings can lead to serious health consequences. Always follow your doctor's advice and report any unusual symptoms promptly.
Is Crizotinib addictive?
Crizotinib is not considered addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Crizotinib works by targeting specific proteins in cancer cells and does not affect brain chemistry in a way that leads to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, rest assured that Crizotinib does not carry this risk.
Is Crizotinib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Crizotinib, such as liver problems and heart rhythm changes. Regular monitoring is important to ensure safety. Crizotinib can be used in the elderly, but dose adjustments may be necessary based on individual health conditions. Always consult your doctor for personalized advice and monitoring while taking Crizotinib.
Is it safe to drink alcohol while taking Crizotinib?
It's best to avoid alcohol while taking Crizotinib. Alcohol can increase the risk of liver problems, which Crizotinib can also cause. Drinking alcohol may worsen side effects like dizziness or nausea. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like unusual fatigue or stomach pain. Talk with your doctor about alcohol use while taking Crizotinib to get personalized advice based on your health situation.
Is it safe to exercise while taking Crizotinib?
You can exercise while taking Crizotinib, but be cautious. This medication can cause dizziness or fatigue, which might affect your exercise capacity. To exercise safely, drink plenty of water and avoid strenuous activities if you feel unwell. Watch for signs of dizziness or unusual fatigue during physical activity. If you notice these symptoms, slow down or stop exercising and rest. Always check with your doctor if you have concerns about exercising while on Crizotinib.
Is it safe to stop Crizotinib?
Stopping Crizotinib suddenly can affect your treatment outcome. If you're taking it for cancer, stopping might allow the cancer to progress. Always talk with your doctor before stopping Crizotinib. They might suggest a gradual reduction or an alternative treatment to maintain control over your condition. Your doctor will help you make any medication changes safely to protect your health.
What are the most common side effects of Crizotinib?
Side effects are unwanted reactions to a medication. Common side effects of Crizotinib include nausea, diarrhea, and vision changes. These occur in varying frequencies among patients. If you experience new symptoms after starting Crizotinib, they might be temporary or unrelated to the medication. Always talk with your doctor before stopping any medication. They can help determine if the side effects are related to Crizotinib and suggest ways to manage them.
Who should avoid taking Crizotinib?
Crizotinib should not be used if you are allergic to it or its ingredients. Serious allergic reactions require immediate medical help. Crizotinib is not recommended for people with severe liver problems, as it can worsen liver function. Caution is needed if you have heart rhythm issues, as Crizotinib can affect heart rhythm. Always consult your doctor about any health concerns before starting Crizotinib to ensure it's safe for you.
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