Crizotinib
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Crizotinib
Summary
Crizotinib is used primarily to treat nonsmall cell lung cancer (NSCLC) and certain types of anaplastic large cell lymphoma (ALCL). It is specifically used for NSCLC that is positive for ALK (anaplastic lymphoma kinase) or ROS1 mutations, and other cancers with similar mutations.
Crizotinib works by targeting specific proteins produced by genetic mutations in certain cancers, including ALK and ROS1. By inhibiting these proteins, it slows down or halts the growth of cancer cells.
The usual dose for adults is 250 mg, taken orally twice a day with or without food. Crizotinib is taken in capsule form, swallowed whole without crushing or chewing them. It's important to take them at the same time each day.
Common side effects of Crizotinib include nausea, diarrhea, fatigue, and vision problems. Some patients may also experience mood changes, sleep problems, headaches, and weight loss. More serious risks include liver damage, lung problems, and heart issues.
Crizotinib should not be used by those with known allergies to Crizotinib or any of its ingredients, or those with certain heart, liver, or lung issues. It's not recommended during pregnancy or breastfeeding. It may interact with other medications, vitamins, and supplements, especially those affecting liver enzymes. Regular monitoring by a doctor is necessary during treatment.
Indications and Purpose
How does Crizotinib work?
Crizotinib targets abnormal proteins produced by genetic mutations in certain cancers, including ALK and ROS1. By inhibiting these proteins, it slows down or halts cancer cell growth.
Is Crizotinib effective?
Crizotinib is effective for cancers with specific genetic mutations, such as ALK and ROS1, and has shown to reduce tumor size or slow cancer progression in clinical studies.
What is Crizotinib?
Crizotinib is a medication used primarily to treat non-small cell lung cancer (NSCLC) and certain types of anaplastic large cell lymphoma (ALCL). It works by targeting specific proteins that promote cancer cell growth, slowing down or stopping the progression of the cancer.
Directions for Use
For how long do I take Crizotinib?
The duration of treatment depends on the type of cancer being treated, the individual’s response to the drug, and the healthcare provider's recommendations. Continue taking Crizotinib until your doctor advises you otherwise.
How do I take Crizotinib?
Crizotinib is taken by mouth in capsule form. Swallow the capsules whole, without crushing or chewing them. Take them at the same time each day to maintain a regular schedule, and avoid consuming grapefruit or grapefruit juice.
How long does it take for Crizotinib to start working?
Crizotinib may start showing benefits within a few weeks of treatment, but the response varies depending on the individual's cancer type and progression. Regular monitoring by your doctor is necessary to assess its effectiveness.
How should I store Crizotinib?
Store Crizotinib at room temperature, away from moisture and heat. Keep it out of reach of children and do not use the medication after its expiration date.
What is the usual dose of Crizotinib?
The usual dose for adults is 250 mg taken orally twice a day with or without food. It’s essential to follow the prescribed dosage based on your condition and doctor’s instructions.
Warnings and Precautions
Can Crizotinib be taken safely while breastfeeding?
It is not recommended to breastfeed while taking Crizotinib, as the drug may pass into breast milk and potentially harm the infant.
Can Crizotinib be taken safely while pregnant?
Crizotinib is not recommended during pregnancy due to potential harm to the unborn baby. Women should use effective contraception and consult their doctor if pregnancy is suspected during treatment.
Can I take Crizotinib with other prescription drugs?
Crizotinib may interact with medications that affect the CYP3A enzymes in the liver, including other cancer drugs, antibiotics, and antifungal medications. Always inform your doctor of any medications you are taking.
Is Crizotinib safe for the elderly?
Elderly patients may experience a higher risk of side effects like liver toxicity, and doses may need to be adjusted accordingly. Monitor closely with regular health checks.
Is it safe to drink alcohol while taking Crizotinib?
Alcohol should be limited or avoided as it may increase liver strain. Talk to your doctor about safe alcohol use during treatment.
Is it safe to exercise while taking Crizotinib?
Moderate exercise is generally safe, but excessive physical strain may worsen side effects like fatigue. Listen to your body and speak with your doctor about the level of exercise appropriate for your condition.
Who should avoid taking Crizotinib?
People with known allergies to Crizotinib or any of its ingredients, or those with certain heart, liver, or lung issues, should avoid using this medication. Consult your doctor for a thorough assessment before starting.
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