Ceritinib
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
ceritinib
Summary
Ceritinib is used to treat non-small cell lung cancer, which is a type of lung cancer. It is specifically for patients whose cancer has a genetic mutation in the ALK gene, which is a gene that can promote cancer cell growth.
Ceritinib works by blocking a protein called ALK, which is involved in the growth of cancer cells. By inhibiting this protein, Ceritinib can slow or stop the growth of cancer cells, helping to reduce tumor size and slow disease progression.
The usual starting dose of Ceritinib for adults is 450 mg taken once daily on an empty stomach, which means at least 2 hours before or after a meal. The maximum recommended dose is 750 mg daily. Always follow your doctor's specific dosing instructions.
Common side effects of Ceritinib include nausea, diarrhea, and abdominal pain, which occur in more than 10% of people taking the medication. These side effects can vary from person to person, and it's important to talk with your doctor if you experience new symptoms.
Ceritinib can cause serious lung problems, liver problems, and heart rhythm changes. It is not recommended for people with severe liver problems. Always inform your doctor about your medical history and any other medications you are taking to avoid potential risks.
Indications and Purpose
How does Ceritinib work?
Ceritinib works by blocking a protein called ALK, which is involved in the growth of cancer cells. Think of it like turning off a switch that allows cancer cells to multiply. By inhibiting this protein, Ceritinib can slow or stop the growth of cancer cells in non-small cell lung cancer. This action helps reduce tumor size and slow disease progression. Ceritinib is effective for patients with a specific genetic mutation in their cancer cells, making it a targeted therapy.
Is Ceritinib effective?
Ceritinib is effective for treating non-small cell lung cancer, which is a type of lung cancer. It works by blocking certain proteins that help cancer cells grow. Clinical studies show that Ceritinib can shrink tumors and slow cancer progression in patients with this type of cancer. The effectiveness of Ceritinib may vary based on individual health conditions and genetic factors. Your doctor will monitor your response to the medication through regular check-ups and tests to ensure it's working effectively for you.
What is Ceritinib?
Ceritinib is a medication used to treat non-small cell lung cancer, which is a type of lung cancer. It belongs to a class of drugs called ALK inhibitors, which work by blocking certain proteins that help cancer cells grow. By inhibiting these proteins, Ceritinib can slow or stop the growth of cancer cells. It's typically used in patients whose cancer has a specific genetic mutation. Ceritinib is often used when other treatments have not been effective or are not suitable.
Directions for Use
For how long do I take Ceritinib?
Ceritinib is usually a long-term medication for managing non-small cell lung cancer. You'll typically take Ceritinib every day as a continuous treatment unless your doctor suggests otherwise. The duration of use depends on your body's response, any side effects you experience, and changes in your overall health. Stopping this medication without medical advice could cause your condition to worsen. Always talk with your doctor before changing or stopping your Ceritinib treatment to ensure your health condition remains under control.
How do I dispose of Ceritinib?
To dispose of Ceritinib, bring unused medicine to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw Ceritinib in the trash at home. First, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Ceritinib?
Take Ceritinib exactly as your doctor prescribes. It's usually taken once daily. You should take it on an empty stomach, which means at least 2 hours before or after a meal. Do not crush or chew the capsules. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Always follow your doctor's specific instructions regarding food, beverages, and missed doses while taking Ceritinib.
How long does it take for Ceritinib to start working?
Ceritinib begins working in your body shortly after you start taking it, but the full therapeutic effects may take several weeks to become noticeable. The time it takes to see results can vary based on individual factors like your overall health and how your body responds to the medication. Regular check-ups and imaging tests with your doctor will help monitor the effectiveness of Ceritinib. It's important to take the medication exactly as prescribed for the best results.
How should I store Ceritinib?
Store Ceritinib at room temperature, away from moisture and light. Keep it in its original container with the lid tightly closed. Do not store it in humid places like bathrooms, as moisture can affect the medication's effectiveness. Ceritinib does not require refrigeration. Always keep it out of reach of children to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication according to local guidelines or your pharmacist's advice.
What is the usual dose of Ceritinib?
The usual starting dose of Ceritinib for adults is 450 mg taken once daily. This dose is typically taken on an empty stomach. Your doctor may adjust the dose based on how you respond to the treatment and any side effects you experience. The maximum recommended dose is 750 mg daily. Dose adjustments may be necessary for special populations, such as those with liver problems. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can Ceritinib be taken safely while breastfeeding?
Ceritinib is not recommended while breastfeeding. There is limited information on whether this medication passes into human breast milk. However, it may pose risks to a breastfed infant. We don't know how Ceritinib might affect milk production or the baby's health. If you're taking Ceritinib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely. Your doctor can help you make informed decisions about your treatment.
Can Ceritinib be taken safely while pregnant?
Ceritinib is not recommended during pregnancy. There is limited evidence on its safety for pregnant women, and it may harm an unborn baby. Animal studies have shown potential risks, but human data is lacking. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your health condition. Your doctor can help create a treatment plan that protects both you and your baby during this important time.
Can I take Ceritinib with other prescription drugs?
Ceritinib can interact with other medications, increasing the risk of side effects or reducing effectiveness. Major interactions include drugs that affect liver enzymes, which can alter Ceritinib levels in your body. Moderate interactions include medications that prolong the QT interval, which can affect heart rhythm. Always inform your doctor about all medications you are taking to avoid potential interactions. Your doctor can help adjust your treatment plan to ensure safety and effectiveness while taking Ceritinib.
Does Ceritinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Ceritinib can cause nausea, diarrhea, and liver problems, which are common adverse effects. Serious side effects include lung problems and heart rhythm changes. If you experience symptoms like difficulty breathing, severe stomach pain, or yellowing of the skin, seek medical help immediately. Always inform your doctor about any new or worsening symptoms while taking Ceritinib. They can help determine if these symptoms are related to the medication and recommend appropriate actions.
Does Ceritinib have any safety warnings?
Yes, Ceritinib has important safety warnings. It can cause serious lung problems, which may lead to difficulty breathing. Liver problems are also a risk, which can cause yellowing of the skin or eyes. Heart rhythm changes, which can be serious, may occur. It's crucial to follow your doctor's instructions and attend regular check-ups. Not adhering to these warnings can lead to severe health issues. If you notice symptoms like chest pain, severe stomach pain, or unusual tiredness, seek medical help immediately.
Is Ceritinib addictive?
Ceritinib is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Ceritinib works by targeting specific proteins in cancer cells, which doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that Ceritinib doesn't carry this risk while managing your health condition.
Is Ceritinib safe for the elderly?
There are no specific dosage adjustments recommended for elderly patients, but they should be monitored closely for side effects. As with all patients, elderly individuals should inform their healthcare provider of any side effects or concerns during treatment.
Is it safe to drink alcohol while taking Ceritinib?
It's best to avoid alcohol while taking Ceritinib. Alcohol can increase the risk of liver problems, which is a potential side effect of Ceritinib. Drinking alcohol may also worsen other side effects like nausea or dizziness. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like unusual tiredness or yellowing of the skin. Talk with your doctor about alcohol use while taking Ceritinib to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Ceritinib?
You can exercise while taking Ceritinib, but be cautious. This medication can cause fatigue and dizziness, which might affect your ability to exercise. If you feel dizzy or unusually tired during physical activity, slow down or stop and rest. To exercise safely, stay hydrated and avoid strenuous activities if you experience side effects. Most people can maintain their regular exercise routine while taking Ceritinib, but check with your doctor if you have concerns about your specific situation.
Is it safe to stop Ceritinib?
Stopping Ceritinib suddenly can cause your cancer to progress or worsen. It's important to follow your doctor's instructions regarding the duration of treatment. If you need to stop taking Ceritinib, your doctor will guide you on how to do so safely. They might suggest gradually reducing your dose or switching to a different medication. Always talk with your doctor before stopping Ceritinib to ensure your health condition remains under control.
What are the most common side effects of Ceritinib?
Side effects are unwanted reactions to a medication. Common side effects of Ceritinib include nausea, diarrhea, and abdominal pain. These occur in more than 10% of people taking the medication. It's important to note that side effects can vary from person to person. If you experience new symptoms after starting Ceritinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication. They can help determine if the symptoms are related to Ceritinib and suggest ways to manage them.
Who should avoid taking Ceritinib?
Ceritinib should not be used if you are allergic to it or any of its ingredients. Serious allergic reactions, which cause rash, hives, or swelling that makes breathing difficult, require immediate medical help. Ceritinib is not recommended for people with severe liver problems, which can worsen with this medication. Always inform your doctor about your medical history and any other medications you are taking. They can help determine if Ceritinib is safe for you and discuss any potential risks.
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