Capmatinib
Non-Small-Cell Lung Carcinoma
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Summary
Capmatinib is used to treat non-small cell lung cancer, which is a type of lung cancer, in patients with specific genetic mutations. It is often prescribed when other treatments have not been effective.
Capmatinib works by blocking a protein called MET, which is involved in cancer cell growth and spread. By inhibiting this protein, it helps slow down or stop the growth of cancer cells, shrinking tumors and slowing disease progression.
Capmatinib is usually taken as a tablet, twice daily, once in the morning and once in the evening. It can be taken with or without food, but should be taken at the same times each day. The typical starting dose is 400 mg.
Common side effects of capmatinib include nausea, vomiting, and fatigue, which means feeling very tired. These effects can vary in frequency and severity among different people.
Capmatinib can cause lung inflammation, which may lead to breathing problems, and liver issues, so regular liver function tests are recommended. It is not recommended during pregnancy or breastfeeding due to potential harm to the baby.
Indications and Purpose
How does capmatinib work?
Capmatinib works by blocking a protein called MET, which is involved in the growth and spread of cancer cells. By inhibiting this protein, capmatinib helps slow down or stop the growth of cancer cells. Think of it like turning off a switch that allows cancer cells to multiply. This action helps shrink tumors and slow disease progression in patients with specific genetic mutations.
Is capmatinib effective?
Capmatinib is effective for treating non-small cell lung cancer with specific genetic mutations. Clinical studies show it can shrink tumors and slow disease progression in patients with these mutations. The effectiveness of capmatinib depends on individual factors, including the presence of the specific genetic mutation it targets. Your doctor will monitor your response to the medication through regular check-ups and tests.
What is capmatinib?
Capmatinib is a medication used to treat non-small cell lung cancer with specific genetic mutations. It belongs to a class of drugs called kinase inhibitors, which work by blocking certain proteins that promote cancer cell growth. Capmatinib is used to slow the progression of cancer and shrink tumors in patients with these mutations. It is often used when other treatments have not been effective.
Directions for Use
For how long do I take capmatinib?
Capmatinib is usually taken long-term for managing non-small cell lung cancer with specific genetic mutations. The duration of use depends on your response to the medication and any side effects you experience. Your doctor will monitor your condition and adjust your treatment as needed. Always talk with your doctor before changing or stopping your capmatinib treatment.
How do I dispose of capmatinib?
To dispose of capmatinib, bring unused medicines to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take capmatinib?
Capmatinib is usually taken twice daily, once in the morning and once in the evening. You should take it with or without food, but try to take it at the same times each day. Do not crush or chew the tablets. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose and continue your regular schedule. Avoid taking two doses at once.
How long does it take for capmatinib to start working?
Capmatinib begins working in your body shortly after you take it, but the time to see noticeable effects can vary. Some patients may notice improvements in symptoms within a few weeks, while others may take longer. The full therapeutic effect may take several months. Your doctor will monitor your progress through regular check-ups and tests to assess how well the medication is working.
How should I store capmatinib?
Store capmatinib at room temperature, away from moisture and light. Keep the medication in its original container with the lid tightly closed. Avoid storing it in humid places like bathrooms. Always keep capmatinib out of reach of children to prevent accidental ingestion. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of capmatinib?
The usual starting dose of capmatinib for adults is 400 mg taken twice daily. Your doctor may adjust your dose based on your response to the medication and any side effects you experience. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can capmatinib be taken safely while breastfeeding?
Capmatinib is not recommended while breastfeeding. There is limited information on whether it passes into human breast milk, but it may pose risks to the baby. If you're taking capmatinib and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can capmatinib be taken safely while pregnant?
Capmatinib is not recommended during pregnancy due to potential harm to the unborn baby. There is limited information on its safety in pregnant women, but animal studies suggest risks. If you're pregnant or planning to become pregnant, talk with your doctor about the safest treatment options for your condition. Your doctor can help create a pregnancy-specific treatment plan.
Can I take capmatinib with other prescription drugs?
Capmatinib can interact with certain medications, including those that affect liver enzymes. These interactions may increase the risk of side effects or reduce the effectiveness of capmatinib. Always inform your doctor about all the medications you are taking, including over-the-counter drugs and supplements, to avoid potential interactions.
Does capmatinib have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of capmatinib include nausea, vomiting, and fatigue. These effects vary in frequency and severity. Serious side effects can include lung inflammation and liver problems. If you experience any new or worsening symptoms, contact your doctor immediately. They can help determine if these symptoms are related to capmatinib and recommend appropriate action.
Does capmatinib have any safety warnings?
Capmatinib has important safety warnings. It can cause lung inflammation, which may lead to breathing problems. If you experience new or worsening cough, shortness of breath, or chest pain, contact your doctor immediately. Capmatinib can also cause liver problems, so regular liver function tests are recommended. If you notice symptoms like yellowing of the skin or eyes, dark urine, or severe fatigue, seek medical attention.
Is capmatinib addictive?
Capmatinib is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that capmatinib doesn't carry this risk.
Is capmatinib safe for the elderly?
Elderly patients may be more vulnerable to the side effects of capmatinib, such as liver problems or lung inflammation. Regular monitoring and dose adjustments may be necessary. It's important for elderly patients to discuss their overall health and any other medications they are taking with their doctor to ensure safe use of capmatinib.
Is it safe to drink alcohol while taking capmatinib?
It's best to avoid alcohol while taking capmatinib. Alcohol can increase the risk of liver problems, which is a potential side effect of capmatinib. Drinking alcohol may also worsen side effects like nausea or dizziness. If you choose to drink occasionally, limit your alcohol intake and watch for any warning signs. Talk with your doctor about alcohol use while taking capmatinib.
Is it safe to exercise while taking capmatinib?
You can exercise while taking capmatinib, but be mindful of your body's response. Capmatinib can cause fatigue or dizziness, which might affect your exercise capacity. To exercise safely, listen to your body and avoid strenuous activities if you feel unwell. Stay hydrated and rest if you experience dizziness or unusual fatigue. Consult your doctor if you have concerns about exercising while on this medication.
Is it safe to stop capmatinib?
Stopping capmatinib suddenly can affect your treatment. If you're taking it for cancer, stopping could allow the cancer to progress. Always talk with your doctor before stopping capmatinib. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely.
What are the most common side effects of capmatinib?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of capmatinib include nausea, vomiting, and fatigue. These effects vary from person to person. If you notice new symptoms after starting capmatinib, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking capmatinib?
Capmatinib should not be used if you are allergic to it or any of its ingredients. Serious allergic reactions require immediate medical help. Capmatinib is not recommended for use during pregnancy or breastfeeding due to potential harm to the baby. Always consult your doctor about any concerns or conditions that might affect your use of capmatinib.
