Brompheniramine + Pseudoephedrine
Find more information about this combination medication at the webpages for pseudoephedrine
Vasomotor Rhinitis , Perennial Allergic Rhinitis ... show more
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Alpha-Adrenergic Agonist
Controlled Drug Substance
NO
Summary
Brompheniramine and pseudoephedrine are used to relieve symptoms of colds and allergies. Brompheniramine, which is an antihistamine, helps with sneezing, itching, and runny nose. Pseudoephedrine, which is a decongestant, reduces nasal congestion. Together, they provide comprehensive relief from discomfort caused by these conditions, improving breathing and reducing overall symptoms.
Brompheniramine works by blocking histamine, which is a chemical causing allergy symptoms like sneezing and itching. Pseudoephedrine narrows blood vessels in the nasal passages, reducing swelling and congestion. Together, they address both the cause of symptoms and the discomfort they cause, providing relief from colds and allergies.
The usual adult dose for brompheniramine is 4 mg every 4 to 6 hours, not exceeding 24 mg per day. For pseudoephedrine, it's 60 mg every 4 to 6 hours, with a maximum of 240 mg per day. These medicines are taken orally, and it's important to follow the dosing instructions on the package or from a healthcare provider.
Common side effects of brompheniramine include drowsiness and dry mouth, typical of antihistamines. Pseudoephedrine may cause increased heart rate and nervousness, common with decongestants. Both can cause dizziness and headache. It's important to monitor for these effects and consult a healthcare provider if they occur.
Avoid brompheniramine and pseudoephedrine if you have high blood pressure, heart disease, or are taking MAOIs, which are used to treat depression. Brompheniramine can cause drowsiness, so avoid driving. Pseudoephedrine can increase heart rate and blood pressure. Consult a healthcare provider before use, especially with underlying health conditions.
Indications and Purpose
How does combination of brompheniramine and pseudoephedrine work?
Brompheniramine works by blocking histamine, which is a chemical in the body that causes allergy symptoms like sneezing and itching. Pseudoephedrine works by narrowing the blood vessels in the nasal passages, which reduces swelling and congestion. Together, they provide relief from symptoms of colds and allergies by addressing both the cause of the symptoms and the discomfort they cause. Brompheniramine targets the allergic response, while pseudoephedrine focuses on reducing nasal congestion, making them an effective combination for symptom relief.
How effective is combination of brompheniramine and pseudoephedrine?
Evidence for the effectiveness of brompheniramine and pseudoephedrine comes from clinical studies and user reports. Brompheniramine, as an antihistamine, has been shown to effectively reduce allergy symptoms like sneezing and runny nose. Pseudoephedrine, as a decongestant, is proven to relieve nasal congestion by shrinking swollen nasal passages. Together, they provide comprehensive relief from cold and allergy symptoms, with studies supporting their combined use for enhanced symptom management. The shared benefit is the overall improvement in breathing and reduction of discomfort.
Directions for Use
What is the usual dose of combination of brompheniramine and pseudoephedrine?
The usual adult daily dose for brompheniramine is typically 4 mg every 4 to 6 hours, not exceeding 24 mg per day. For pseudoephedrine, the common dose is 60 mg every 4 to 6 hours, with a maximum of 240 mg per day. These doses can vary based on the specific product formulation and individual health needs. It's important to follow the dosing instructions on the package or those provided by a healthcare provider to ensure safe and effective use.
How does one take combination of brompheniramine and pseudoephedrine?
Brompheniramine and pseudoephedrine can be taken with or without food, but taking them with food may help reduce stomach upset. There are no specific food restrictions associated with these medicines. However, it's important to avoid alcohol, as it can increase drowsiness caused by brompheniramine. Always follow the dosing instructions on the package or those provided by a healthcare provider. If you have any concerns about food interactions, consult your healthcare provider for personalized advice.
For how long is combination of brompheniramine and pseudoephedrine taken?
The typical duration of use for brompheniramine and pseudoephedrine is usually short-term, often not exceeding 7 to 10 days. They are intended for temporary relief of cold and allergy symptoms. Prolonged use is not recommended without consulting a healthcare provider, as it may lead to increased side effects or reduced effectiveness. If symptoms persist beyond this period, it's important to seek medical advice to determine the underlying cause and appropriate treatment.
How long does it take for combination of brompheniramine and pseudoephedrine to work?
Brompheniramine and pseudoephedrine typically start working within 30 minutes to an hour after taking them. Brompheniramine, which is an antihistamine, helps reduce allergy symptoms like sneezing and runny nose. Pseudoephedrine, which is a decongestant, works by narrowing the blood vessels in the nasal passages to relieve congestion. Both medicines work together to provide relief from cold and allergy symptoms, and their effects can be felt relatively quickly after ingestion.
Warnings and Precautions
Are there harms and risks from taking combination of brompheniramine and pseudoephedrine?
Common side effects of brompheniramine include drowsiness and dry mouth, which are typical of antihistamines. Pseudoephedrine may cause side effects like increased heart rate and nervousness, which are common with decongestants. Both medicines can cause dizziness and headache. Significant adverse effects, though rare, may include severe allergic reactions or heart palpitations. It's important to monitor for these effects and consult a healthcare provider if they occur. The shared side effects are mainly related to their impact on the nervous system and cardiovascular system.
Can I take combination of brompheniramine and pseudoephedrine with other prescription drugs?
Brompheniramine and pseudoephedrine can interact with several prescription drugs. Brompheniramine may increase the sedative effects of other central nervous system depressants, like benzodiazepines. Pseudoephedrine can interact with blood pressure medications, potentially reducing their effectiveness. Both medicines can interact with MAOIs, leading to dangerous increases in blood pressure. It's crucial to inform your healthcare provider about all prescription medications you are taking to avoid these interactions. Monitoring for increased side effects or changes in blood pressure can help manage these interactions.
Can I take combination of brompheniramine and pseudoephedrine if I am pregnant?
The safety of brompheniramine and pseudoephedrine during pregnancy is not fully established. Brompheniramine, as an antihistamine, may pose risks if taken in the first trimester, potentially affecting fetal development. Pseudoephedrine, a decongestant, is generally advised to be avoided during the first trimester due to potential risks to the fetus. Both medicines should only be used during pregnancy if the potential benefits justify the potential risks. Pregnant women should consult their healthcare provider before using these medications to ensure safety for both mother and baby.
Can I take combination of brompheniramine and pseudoephedrine while breastfeeding?
During lactation, brompheniramine and pseudoephedrine should be used with caution. Brompheniramine can pass into breast milk and may cause drowsiness or irritability in the nursing infant. Pseudoephedrine can also pass into breast milk and may reduce milk supply. Both medicines should be used only if the benefits outweigh the risks. Nursing mothers should consult their healthcare provider before using these medications to ensure the safety of the infant. Monitoring the infant for any adverse effects is also recommended if these medicines are used.
Who should avoid taking combination of brompheniramine and pseudoephedrine?
Important warnings for brompheniramine and pseudoephedrine include avoiding use if you have high blood pressure, heart disease, or are taking MAOIs. Brompheniramine can cause drowsiness, so avoid driving or operating heavy machinery. Pseudoephedrine can increase heart rate and blood pressure, so it's contraindicated in people with cardiovascular issues. Both medicines should be used with caution in people with glaucoma or urinary retention. Always consult a healthcare provider before use, especially if you have underlying health conditions or are taking other medications.
