Belzutifan
Von Hippel-Lindau Disease
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Hypoxia-inducible Factor Inhibitor
Controlled Drug Substance
No
Belzutifan
Summary
Belzutifan is used to treat certain types of tumors, particularly those associated with von Hippel-Lindau disease, which is a genetic disorder that can lead to tumor growth.
Belzutifan works by inhibiting a protein called HIF-2α, which helps slow the growth of cancer cells. This action helps manage the disease and improve health outcomes.
The usual starting dose of Belzutifan for adults is 120 mg once daily. It is taken orally, which means by mouth, and can be taken with or without food.
Common side effects of Belzutifan include fatigue, which means feeling very tired, dizziness, and nausea, which refers to feeling sick to your stomach.
Belzutifan can cause low oxygen levels in the blood, known as hypoxia, which requires monitoring. It should not be used if you have severe liver problems or are allergic to its ingredients.
Indications and Purpose
How does Belzutifan work?
Belzutifan works by inhibiting a protein called HIF-2α, which is involved in the growth of certain tumors. By blocking this protein, Belzutifan helps slow down the growth of cancer cells. Think of it like turning off a switch that allows cancer cells to grow. This action helps manage the disease and improve health outcomes.
Is Belzutifan effective?
Belzutifan is effective in treating certain types of tumors by inhibiting a protein called HIF-2α. This helps slow the growth of cancer cells. Clinical studies have shown that Belzutifan can reduce tumor size and improve health outcomes in patients with specific conditions. Your doctor will monitor your progress to ensure the medication is working effectively for you.
What is Belzutifan?
Belzutifan is a medication used to treat certain types of tumors. It works by inhibiting a protein called HIF-2α, which helps slow the growth of cancer cells. This medication is part of a class of drugs known as HIF-2α inhibitors. It's used to manage specific conditions and is often part of a comprehensive treatment plan.
Directions for Use
For how long do I take Belzutifan?
Belzutifan is usually a long-term medication for managing certain types of tumors. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Belzutifan treatment.
How do I dispose of Belzutifan?
Dispose of unused Belzutifan by taking it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Belzutifan?
Take Belzutifan as directed by your doctor, usually once daily. You can take it with or without food. Do not crush or chew the tablets. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Follow any specific dietary or beverage restrictions your doctor advises.
How long does it take for Belzutifan to start working?
Belzutifan begins working in your body shortly after you take it, but the full therapeutic effects may take weeks to months to become noticeable. The time it takes to work can depend on your overall health and the specific condition being treated. Regular check-ups with your doctor are important to monitor your progress.
How should I store Belzutifan?
Store Belzutifan at room temperature, away from moisture and light. Keep it in its original container, tightly closed, and out of reach of children. Do not store it in humid places like bathrooms. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Belzutifan?
The usual starting dose of Belzutifan for adults is 120 mg once daily. Your doctor may adjust your dose based on your response to the medication and any side effects you experience. Always follow your doctor's specific dosing instructions for your personal health needs. If you have any questions about your dose, consult your healthcare provider.
Warnings and Precautions
Can Belzutifan be taken safely while breastfeeding?
Belzutifan is not recommended while breastfeeding. There is limited information on whether it passes into human breast milk. If you're taking Belzutifan and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can Belzutifan be taken safely while pregnant?
Belzutifan is not recommended during pregnancy due to potential risks to the unborn baby. There is limited information on its safety in pregnant women. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take Belzutifan with other prescription drugs?
Belzutifan can interact with certain medications, increasing the risk of side effects or reducing its effectiveness. It's important to inform your doctor about all the medications you're taking, including over-the-counter drugs and supplements. Your doctor can help manage any potential interactions and adjust your treatment plan as needed.
Does Belzutifan have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Belzutifan include fatigue, dizziness, and nausea. These effects vary in frequency and severity. Serious side effects can include low oxygen levels in the blood, which require immediate medical attention. Always inform your doctor about any new or worsening symptoms while taking Belzutifan.
Does Belzutifan have any safety warnings?
Yes, Belzutifan has important safety warnings. It can cause low oxygen levels in the blood, which is called hypoxia. This can be serious and requires monitoring. If you experience symptoms like shortness of breath, dizziness, or fatigue, contact your doctor immediately. Regular blood tests may be needed to monitor your oxygen levels while taking this medication.
Is Belzutifan addictive?
Belzutifan is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. It works by targeting specific proteins in the body and doesn't affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, you can feel confident that Belzutifan doesn't carry this risk.
Is Belzutifan safe for the elderly?
Elderly patients may be more vulnerable to side effects of Belzutifan, such as dizziness and low oxygen levels. It's important for older adults to be closely monitored by their doctor while taking this medication. Regular check-ups can help manage any potential risks and ensure the medication is safe and effective for elderly users.
Is it safe to drink alcohol while taking Belzutifan?
It's best to avoid alcohol while taking Belzutifan. Alcohol can increase the risk of side effects like dizziness and low oxygen levels in the blood. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like dizziness or shortness of breath. Talk with your doctor about alcohol use while taking Belzutifan.
Is it safe to exercise while taking Belzutifan?
You can exercise while taking Belzutifan, but be cautious. This medication can cause dizziness or low oxygen levels, which might affect your ability to exercise. To exercise safely, drink plenty of water and watch for signs of dizziness or fatigue. If you notice these symptoms, slow down or stop exercising and rest. Consult your doctor if you have concerns.
Is it safe to stop Belzutifan?
Stopping Belzutifan suddenly can cause your condition to worsen. It's important to talk with your doctor before stopping this medication. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely to protect your health.
What are the most common side effects of Belzutifan?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Belzutifan include fatigue, dizziness, and nausea. These effects vary from person to person. If you notice new symptoms after starting Belzutifan, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Belzutifan?
Belzutifan should not be used if you have severe liver problems or are allergic to any of its ingredients. These are absolute contraindications. Use caution if you have a history of low oxygen levels in the blood, as this is a relative contraindication. Always consult your doctor about any concerns before starting Belzutifan.
