Azacitidine
Refractory Anemia, Sideroblastic Anemia ... show more
.svg)
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Nucleoside Metabolic Inhibitor
Controlled Drug Substance
No
azacitidine
Summary
Azacitidine is used to treat certain blood disorders and cancers, like myelodysplastic syndromes, which are conditions where the bone marrow does not produce enough healthy blood cells.
Azacitidine works by interfering with the growth of cancer cells, which are cells that multiply uncontrollably, helping to restore normal blood cell production.
The usual starting dose for adults is 75 mg per square meter of body surface area, given as an injection under the skin or into a vein once daily for seven days in a 28-day cycle.
Common side effects include nausea, which is feeling sick to your stomach, vomiting, and low blood cell counts, which can increase the risk of infections or bleeding.
Azacitidine should not be used if you're allergic to it. It's not recommended for pregnant or breastfeeding women due to potential harm to the baby. Regular blood tests are needed to monitor for low blood cell counts.
Indications and Purpose
How does Azacitidine work?
Azacitidine works by interfering with the growth of cancer cells. It belongs to a class of drugs called antimetabolites. Think of it like a roadblock that stops cancer cells from multiplying. This helps restore normal blood cell production and is effective in treating certain blood disorders and cancers.
Is Azacitidine effective?
Azacitidine is effective for treating certain blood disorders and cancers, like myelodysplastic syndromes. It works by helping to restore normal blood cell production. Clinical studies show Azacitidine improves survival rates and reduces the need for blood transfusions. Your doctor will monitor your progress with regular blood tests to ensure the medication is working effectively.
What is Azacitidine?
Azacitidine is a medication used to treat certain blood disorders and cancers, like myelodysplastic syndromes. It belongs to a class of drugs called antimetabolites, which work by interfering with the growth of cancer cells. Azacitidine helps restore normal blood cell production and can be used alone or with other therapies.
Directions for Use
For how long do I take Azacitidine?
Azacitidine is usually used for long-term treatment of certain blood disorders and cancers. The duration depends on your response and any side effects. Your doctor will guide you on how long to continue treatment. Always talk with your doctor before changing or stopping Azacitidine.
How do I dispose of Azacitidine?
Dispose of Azacitidine through a drug take-back program or collection site at a pharmacy or hospital. If unavailable, mix it with undesirable substances like used coffee grounds, seal in a plastic bag, and throw it away. This prevents harm to people and the environment.
How do I take Azacitidine?
Azacitidine is usually given as an injection under the skin or into a vein. It's typically administered once daily for seven days in a 28-day cycle. Your healthcare provider will determine the exact schedule and dosage based on your condition. Azacitidine should not be crushed or taken with food. If you miss a dose, contact your healthcare provider for instructions. Always follow your doctor's specific advice regarding the administration of Azacitidine.
How long does it take for Azacitidine to start working?
Azacitidine starts working shortly after administration, but full effects may take several cycles. Improvement in blood cell counts can be seen within a few weeks. The time it takes to achieve full therapeutic effect varies based on individual response and health condition. Regular monitoring by your doctor is important to assess progress.
How should I store Azacitidine?
Store Azacitidine at room temperature, away from moisture and light. It doesn't need refrigeration. Keep it in its original container, tightly closed, and out of reach of children. Avoid storing it in humid places like bathrooms. Check the expiration date regularly and dispose of any unused or expired medication properly.
What is the usual dose of Azacitidine?
The usual starting dose of Azacitidine for adults is 75 mg per square meter of body surface area, given once daily for seven days in a 28-day cycle. Your doctor may adjust the dose based on your response and any side effects. There are no specific dosing instructions for children or the elderly, but adjustments may be needed. Always follow your doctor's dosing instructions for your specific health needs.
Warnings and Precautions
Can Azacitidine be taken safely while breastfeeding?
Azacitidine is not recommended while breastfeeding. It's unclear if it passes into breast milk, but it may pose risks to the baby. If you're breastfeeding and need treatment, discuss safer medication options with your doctor. They can help you make informed decisions about your treatment and breastfeeding.
Can Azacitidine be taken safely while pregnant?
Azacitidine is not recommended during pregnancy due to potential harm to the unborn baby. Limited evidence exists on its safety in pregnant women. If you're pregnant or planning to become pregnant, talk with your doctor about safer treatment options. They can help create a plan that protects both you and your baby.
Can I take Azacitidine with other prescription drugs?
Azacitidine can interact with other medications, increasing the risk of side effects or reducing effectiveness. It's important to inform your doctor about all medications you're taking. They can help manage potential interactions and adjust your treatment plan as needed. Always follow your doctor's advice regarding medication use.
Does Azacitidine have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Azacitidine include nausea, vomiting, and low blood cell counts. Serious effects can include liver or kidney damage. If you notice new or worsening symptoms, contact your doctor. They can help determine if these are related to Azacitidine and suggest appropriate actions.
Does Azacitidine have any safety warnings?
Yes, Azacitidine has important safety warnings. It can cause low blood cell counts, increasing infection or bleeding risk. It may also harm the liver or kidneys. Regular blood tests are needed to monitor your health. If you experience unusual bruising, bleeding, or signs of infection, contact your doctor immediately. Adhering to safety warnings is crucial to avoid serious health consequences.
Is Azacitidine addictive?
Azacitidine is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Azacitidine works by affecting cancer cells, not brain chemistry, so it doesn't lead to addiction. You won't experience cravings or feel compelled to take more than prescribed. If you have concerns about medication dependence, Azacitidine doesn't carry this risk.
Is Azacitidine safe for the elderly?
Elderly patients may be more vulnerable to Azacitidine's side effects, such as low blood cell counts and fatigue. Regular monitoring is important to ensure safety. Your doctor may adjust the dose based on your health and response to treatment. Always discuss any concerns with your healthcare provider.
Is it safe to drink alcohol while taking Azacitidine?
It's best to avoid alcohol while taking Azacitidine. Alcohol can increase the risk of liver damage and worsen side effects like nausea. If you choose to drink, limit your intake and watch for warning signs like stomach pain or dizziness. Talk with your doctor about alcohol use while on Azacitidine for personalized advice.
Is it safe to exercise while taking Azacitidine?
You can exercise while taking Azacitidine, but be cautious. This medication can cause fatigue and low blood cell counts, which might affect your energy levels. Listen to your body and avoid strenuous activities if you feel weak. Stay hydrated and rest as needed. Consult your doctor if you have concerns about exercising while on Azacitidine.
Is it safe to stop Azacitidine?
Stopping Azacitidine suddenly can affect your treatment. It's used for long-term management of certain cancers. Stopping without medical advice may worsen your condition. Always talk with your doctor before stopping Azacitidine. They can guide you on safely adjusting your treatment plan.
What are the most common side effects of Azacitidine?
Side effects are unwanted reactions to a medication. Common side effects of Azacitidine include nausea, vomiting, and low blood cell counts. These effects vary among individuals. If you experience new symptoms, they might be temporary or unrelated to Azacitidine. Always talk with your doctor before stopping any medication.
Who should avoid taking Azacitidine?
Azacitidine should not be used if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. It's not recommended for pregnant or breastfeeding women due to potential harm to the baby. People with severe liver or kidney problems should use it cautiously. Always consult your doctor about these concerns.
Forms / Brands
