Avatrombopag
Thrombocytopenia
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
NA
Controlled Drug Substance
No
Avatrombopag
Summary
Avatrombopag is used to treat low platelet counts in adults with chronic liver disease who are scheduled for a procedure, and in those with chronic immune thrombocytopenia who have not responded to other treatments.
Avatrombopag works by stimulating the production of platelets, which are essential for blood clotting. It does this by activating the thrombopoietin receptor, which leads to increased platelet production.
For adults with chronic liver disease, the usual dose is 40 mg to 60 mg once daily for 5 days. For chronic immune thrombocytopenia, the starting dose is 20 mg once daily, adjusted based on platelet response.
Common side effects of Avatrombopag include headache, fatigue, and nausea. Serious adverse effects include thrombotic events, which occur in some patients.
Avatrombopag can increase the risk of blood clots, especially in patients with chronic liver disease or chronic immune thrombocytopenia. It should not be used to normalize platelet counts. Pregnant and breastfeeding women should avoid using it.
Indications and Purpose
How does Avatrombopag work?
Avatrombopag works by stimulating the production of platelets in the bone marrow. It belongs to a class of drugs called thrombopoietin receptor agonists, which mimic the action of a natural protein in the body that promotes platelet production. Think of it like a gardener using fertilizer to help plants grow. By increasing platelet counts, Avatrombopag helps reduce the risk of bleeding in people with low platelet levels due to conditions like chronic immune thrombocytopenia or chronic liver disease.
Is Avatrombopag effective?
Yes, Avatrombopag is effective for increasing platelet counts in people with chronic immune thrombocytopenia, which is a condition where the immune system attacks and destroys platelets. Clinical studies show that Avatrombopag significantly increases platelet counts, reducing the risk of bleeding. It is also used to manage low platelet counts in people with chronic liver disease who are undergoing medical procedures. Always follow your doctor's advice to ensure the best outcomes with this medication.
What is Avatrombopag?
Avatrombopag is a medication used to increase platelet counts in people with chronic immune thrombocytopenia, which is a condition where the immune system attacks and destroys platelets. It belongs to a class of drugs called thrombopoietin receptor agonists, which stimulate the production of platelets in the bone marrow. Avatrombopag is also used to manage low platelet counts in people with chronic liver disease who are undergoing medical procedures. It helps reduce the risk of bleeding in these conditions.
Directions for Use
For how long do I take Avatrombopag?
Avatrombopag is usually taken long-term for chronic conditions like low platelet counts. The duration of use depends on your specific health needs and how your body responds to the medication. Your doctor will monitor your condition and adjust your treatment plan as needed. Always follow your doctor's advice and don't stop taking Avatrombopag without consulting them, as this could lead to a decrease in platelet levels and increase the risk of bleeding.
How do I dispose of Avatrombopag?
To dispose of Avatrombopag, take it to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of it properly to prevent harm to people or the environment. If you can't find a take-back program, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Avatrombopag?
Take Avatrombopag as directed by your doctor, usually once daily. You can take it with or without food. Do not crush the tablet. If you miss a dose, take it as soon as you remember, unless it's almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. There are no specific dietary or beverage restrictions, but always follow your doctor's advice. If you have any questions about taking Avatrombopag, consult your healthcare provider.
How long does it take for Avatrombopag to start working?
Avatrombopag starts working within a few days, but it may take several weeks to achieve its full therapeutic effect. The time it takes to work can vary depending on individual factors like your condition and overall health. Your doctor will monitor your platelet levels through regular blood tests to assess how well the medication is working. Always take Avatrombopag as prescribed and follow your doctor's instructions for the best results.
How should I store Avatrombopag?
Store Avatrombopag at room temperature, between 68°F to 77°F, in a tightly closed container to protect it from moisture and light. Do not refrigerate or freeze the medication. Keep it out of reach of children and pets to prevent accidental ingestion. Avoid storing it in humid places like bathrooms, as moisture can affect its effectiveness. Always check the expiration date and properly dispose of any unused or expired medication.
What is the usual dose of Avatrombopag?
The usual starting dose of Avatrombopag for adults is 20 mg once daily. Your doctor may adjust the dose based on your response and specific health needs. The maximum recommended dose is 40 mg daily. For special populations, such as children or the elderly, dose adjustments may be necessary. Always follow your doctor's specific dosing instructions and consult them if you have any questions about your dosage.
Warnings and Precautions
Can Avatrombopag be taken safely while breastfeeding?
The safety of Avatrombopag while breastfeeding is not well-established. It's unclear if the medication passes into breast milk or affects milk supply. If you are breastfeeding or planning to breastfeed, talk with your doctor about the potential risks and benefits. They can help determine the safest treatment options for you and your baby. Always follow your healthcare provider's advice regarding medication use while breastfeeding.
Can Avatrombopag be taken safely while pregnant?
The safety of Avatrombopag during pregnancy is not well-established. Limited data is available, and the effects on an unborn baby are not fully known. If you are pregnant or planning to become pregnant, discuss the risks and benefits of using Avatrombopag with your doctor. They can help determine the safest treatment plan for you and your baby. Always follow your healthcare provider's advice regarding medication use during pregnancy.
Can I take Avatrombopag with other prescription drugs?
Avatrombopag can interact with certain medications, increasing the risk of adverse effects or reducing its effectiveness. Major interactions include anticoagulants, which are blood thinners, as they can increase bleeding risk. Moderate interactions may occur with drugs that affect liver enzymes, which can alter Avatrombopag levels in the body. Always inform your doctor about all medications you are taking to prevent interactions and ensure safe and effective treatment.
Does Avatrombopag have adverse effects?
Adverse effects are unwanted reactions to a medication. With Avatrombopag, common adverse effects include headache, fatigue, and nausea. These occur in a small percentage of users. Serious adverse effects, like blood clots, are rare but require immediate medical attention. If you experience any new or worsening symptoms while taking Avatrombopag, contact your doctor. They can help determine if these symptoms are related to the medication and advise on the best course of action.
Does Avatrombopag have any safety warnings?
Yes, Avatrombopag has important safety warnings. It can increase the risk of blood clots, which are clumps of blood that can block blood vessels. This risk is higher if you have a history of blood clots. Not following safety warnings can lead to serious health issues like stroke or heart attack. Always follow your doctor's instructions and report any unusual symptoms, such as swelling, pain, or difficulty breathing, immediately.
Is Avatrombopag addictive?
No, Avatrombopag is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Avatrombopag works by increasing platelet production in the body, which doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that Avatrombopag doesn't carry this risk.
Is Avatrombopag safe for the elderly?
Elderly individuals may be more vulnerable to the side effects of Avatrombopag, such as an increased risk of blood clots. It's important for older adults to be closely monitored by their healthcare provider while taking this medication. Regular check-ups and blood tests can help ensure the medication is working safely and effectively. Always follow your doctor's advice and report any unusual symptoms promptly.
Is it safe to drink alcohol while taking Avatrombopag?
It's best to avoid alcohol while taking Avatrombopag. Alcohol can increase the risk of bleeding, which is a concern for people with low platelet counts. Drinking alcohol may also interfere with the effectiveness of the medication. If you choose to drink occasionally, limit your alcohol intake and discuss it with your doctor. They can provide personalized advice based on your specific health situation.
Is it safe to exercise while taking Avatrombopag?
Yes, you can exercise while taking Avatrombopag, but be cautious. This medication can increase the risk of bleeding, so avoid high-impact sports or activities that could lead to injury. Listen to your body and stop exercising if you feel dizzy or fatigued. Stay hydrated and consult your doctor about safe exercise options. They can provide guidance based on your specific health needs and condition.
Is it safe to stop Avatrombopag?
It's important to consult your doctor before stopping Avatrombopag. This medication is often used long-term for chronic conditions like low platelet counts. Stopping it suddenly can lead to a rapid decrease in platelet levels, increasing the risk of bleeding. Your doctor may suggest a gradual reduction or an alternative treatment to manage your condition safely. Always follow your healthcare provider's guidance when making changes to your medication regimen.
What are the most common side effects of Avatrombopag?
Side effects are unwanted reactions that can occur with medication use. Common side effects of Avatrombopag include headache, fatigue, and nausea. These side effects are generally mild and occur in a small percentage of people. If you experience new symptoms after starting Avatrombopag, they might be temporary or unrelated to the medication. Always talk with your doctor before stopping any medication, as they can help determine the cause of your symptoms and provide guidance.
Who should avoid taking Avatrombopag?
Do not use Avatrombopag if you are allergic to it or any of its ingredients. Serious allergic reactions, which cause rash, hives, or swelling that makes breathing difficult, require immediate medical help. Avatrombopag should be used with caution in people with a history of blood clots, as it can increase the risk of clotting. Always consult your doctor about any health conditions you have before starting Avatrombopag to ensure it's safe for you.
