Atogepant
Migraine Disorders
.svg)
Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Calcitonin Gene-related Peptide Receptor Antagonist
Controlled Drug Substance
No
Atogepant
Summary
Atogepant is used to prevent migraine headaches in adults. Migraines are severe, throbbing headaches often accompanied by nausea and sensitivity to light or sound.
Atogepant works by blocking the action of a natural substance in the body called calcitonin gene-related peptide (CGRP) receptors. These receptors are involved in the development of migraines. By blocking these receptors, Atogepant helps prevent migraines.
The usual daily dose of Atogepant for episodic migraine is 10 mg, 30 mg, or 60 mg taken once daily. For chronic migraine, the recommended dose is 60 mg once daily. It should be taken with or without food at the same time each day.
The most frequently reported side effects of Atogepant include nausea, constipation, and fatigue or sleepiness. Other side effects can include decreased appetite and weight loss. If any of these side effects are severe or persistent, you should contact your healthcare provider.
Atogepant is not recommended for use during pregnancy or while breastfeeding. It should be avoided in patients with severe hepatic impairment or a history of hypersensitivity to the drug. It can cause fatigue or sleepiness, which could affect the ability to drive. Always inform your healthcare provider of all medications, vitamins, and supplements you are taking to avoid potential interactions.
Indications and Purpose
How does Atogepant work?
Atogepant works by blocking a protein called CGRP, which is involved in migraine attacks. Think of it like putting a lock on a door to prevent unwanted guests. By blocking CGRP, Atogepant helps prevent migraines from occurring. This medication is effective in reducing the frequency of migraine days in people who suffer from migraines. Always follow your doctor's instructions when using Atogepant.
Is Atogepant effective?
Atogepant is effective for preventing migraines in adults. Clinical studies show it significantly reduces the number of migraine days per month compared to placebo. This medication works by blocking a protein involved in migraine attacks, helping to prevent them. If you have migraines, Atogepant can be an effective part of your treatment plan. Always follow your doctor's advice and report any changes in your symptoms.
What is Atogepant?
Atogepant is a medication used to prevent migraines in adults. It belongs to a class of drugs called CGRP receptor antagonists, which work by blocking a protein involved in migraine attacks. This helps reduce the frequency of migraines. Atogepant is taken orally and is part of a comprehensive migraine management plan. Always follow your doctor's instructions when using this medication.
Directions for Use
For how long do I take Atogepant?
Atogepant is usually a long-term medication for preventing migraines. You'll typically take Atogepant every day as a lifelong treatment unless your doctor suggests otherwise. How long you'll need this medication depends on your body's response, any side effects you experience, and changes in your overall health. Always talk with your doctor before changing or stopping your Atogepant treatment.
How do I dispose of Atogepant?
If you can, bring unused Atogepant to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Atogepant?
Take Atogepant as prescribed by your doctor. It's usually taken once daily, with or without food. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Follow any dietary or beverage restrictions your doctor advises.
How long does it take for Atogepant to start working?
Atogepant begins working in your body shortly after you take it, but it may take several weeks to see the full benefits. The time it takes to achieve its full therapeutic effect can vary based on individual factors like your overall health and how your body responds to the medication. Consistent use as prescribed by your doctor is important for the best results.
How should I store Atogepant?
Store Atogepant at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms, where moisture could affect how well the medication works. Always store Atogepant out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Atogepant?
The usual starting dose of Atogepant for adults is 10 mg once daily, with or without food. Your doctor may adjust your dose based on your response and needs. The maximum recommended dose is 25 mg daily. Always follow your doctor's specific dosing instructions. Special populations, such as the elderly, may require careful monitoring and dose adjustments.
Warnings and Precautions
Can Atogepant be taken safely while breastfeeding?
The safety of Atogepant while breastfeeding is not well-established. It's unclear if this medication passes into breast milk or affects milk supply. If you're breastfeeding or planning to breastfeed, talk with your doctor about the safest way to manage your migraines. Your doctor can help create a treatment plan that allows you to nurse your baby safely.
Can Atogepant be taken safely while pregnant?
The safety of Atogepant during pregnancy is not well-established. Limited data is available, and the effects on an unborn baby are unknown. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your migraines. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take Atogepant with other prescription drugs?
Atogepant can interact with strong CYP3A4 inhibitors, which can increase its exposure in the body. For episodic migraine, the dose should be adjusted to 10 mg daily when taken with these inhibitors. It is advised to avoid using Atogepant with strong CYP3A4 inducers for chronic migraine, as they can decrease its effectiveness.
Does Atogepant have adverse effects?
Adverse effects are unwanted reactions to a medication. With Atogepant, common adverse effects include nausea and fatigue. These effects vary from person to person. Serious adverse effects are rare but can include liver problems. If you notice any new or worsening symptoms, contact your doctor. They can help determine if these symptoms are related to Atogepant and recommend appropriate action.
Does Atogepant have any safety warnings?
Atogepant has important safety warnings. It can cause serious side effects like liver problems, which may include symptoms like yellowing of the skin or eyes. If you experience these symptoms, seek medical help immediately. Atogepant can also cause allergic reactions, so stop taking it and get help if you develop signs of an allergic reaction. Always follow your doctor's advice and report any new or worsening symptoms.
Is Atogepant addictive?
Atogepant is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Atogepant works by affecting certain pathways in the body to help manage migraines. It doesn't affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, you can feel confident that Atogepant doesn't carry this risk.
Is Atogepant safe for the elderly?
For elderly patients, there are no specific dose adjustments required for Atogepant. However, caution is advised when selecting a dose, usually starting at the lower end of the dosing range. This is due to the greater likelihood of decreased liver, kidney, or heart function, and the presence of other medical conditions or medications in older adults.
Is it safe to drink alcohol while taking Atogepant?
It's best to avoid alcohol while taking Atogepant. Alcohol can trigger migraines and may worsen side effects like dizziness or nausea. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like headache or dizziness. Talk with your doctor about alcohol use while taking Atogepant to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Atogepant?
You can exercise while taking Atogepant, but keep a few things in mind. This medication can cause dizziness or fatigue, which might affect your exercise capacity. To exercise safely, start with light activities and gradually increase intensity. Watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest. Most people can maintain their regular exercise routine while taking Atogepant.
Is it safe to stop Atogepant?
Atogepant is usually taken for migraine prevention, which is a long-term treatment. Stopping Atogepant suddenly may lead to a return of migraine symptoms. Always talk with your doctor before stopping Atogepant. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Your doctor will help you make any medication changes safely.
What are the most common side effects of Atogepant?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Atogepant include nausea, fatigue, and constipation. These effects vary from person to person. If you notice new symptoms after starting Atogepant, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Atogepant?
Don't take Atogepant if you're allergic to it or its ingredients. Serious allergic reactions, which cause rash, hives, or swelling that makes breathing difficult, require immediate medical help. Atogepant is not recommended for people with severe liver problems. Always consult your doctor about any health conditions you have before starting Atogepant to ensure it's safe for you.
