Atenolol + Chlorthalidone
Find more information about this combination medication at the webpages for atenolol and chlorthalidone
Hypertension, Renal Insufficiency ... show more
.svg)
Advisory
- This medicine contains a combination of 2 drugs atenolol and chlorthalidone.
- atenolol and chlorthalidone are both used to treat the same disease or symptom but work in different ways in the body.
- Most doctors will advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
Possible
Pharmaceutical Class
Beta-Adrenergic Blocker and Thiazide-like Diuretic
Controlled Drug Substance
NO
Summary
Atenolol is used to treat high blood pressure, which is a condition where the force of the blood against the artery walls is too high, and angina, which is chest pain due to reduced blood flow to the heart. Chlorthalidone is used for high blood pressure and fluid retention, which is the buildup of excess fluid in the body. Together, they help manage hypertension and reduce the risk of heart attacks and strokes.
Atenolol works by blocking beta-adrenergic receptors, which slows the heart rate and relaxes blood vessels, improving blood flow and reducing blood pressure. Chlorthalidone acts as a diuretic, which is a substance that promotes the elimination of excess water and salt through urine, decreasing blood volume and pressure. Together, they provide a dual approach to managing hypertension, reducing cardiovascular risk.
Atenolol is usually taken orally at a dose of 50 mg daily, which can be increased to 100 mg if needed. Chlorthalidone is typically taken orally at a dose of 25 mg daily. When combined in a single tablet, the initial dose is often 50 mg of atenolol and 25 mg of chlorthalidone, taken once a day. Dosages may be adjusted based on individual needs and response to treatment.
Common side effects of atenolol include dizziness, which is a feeling of unsteadiness, tiredness, and depression, which is a mood disorder causing persistent sadness. Chlorthalidone may cause muscle weakness, dizziness, and stomach upset. Both medications can lead to low blood pressure and electrolyte imbalances, which are disturbances in the levels of minerals in the blood. Serious side effects should be reported to a doctor immediately.
Atenolol should not be used in patients with severe bradycardia, which is an abnormally slow heart rate, or heart block, which is a problem with the heart's electrical system. Chlorthalidone is contraindicated in patients with anuria, which is the absence of urine production, or severe renal impairment. Both medications require caution in patients with diabetes, as they can mask low blood sugar symptoms. Regular monitoring by a healthcare provider is essential.
Indications and Purpose
How does combination of Atenolol and Chlorthalidone work?
Atenolol works by blocking beta-adrenergic receptors, which slows the heart rate and relaxes blood vessels, improving blood flow and reducing blood pressure. Chlorthalidone acts as a diuretic, promoting the elimination of excess water and salt through urine, which decreases blood volume and pressure. Together, they provide a dual approach to managing hypertension: atenolol reduces the heart's workload, while chlorthalidone reduces fluid retention, both contributing to lower blood pressure and reduced cardiovascular risk.
How effective is combination of Atenolol and Chlorthalidone?
The effectiveness of atenolol and chlorthalidone in treating hypertension is supported by clinical trials and studies. Atenolol, as a beta-blocker, has been shown to reduce heart rate and blood pressure, improving outcomes in patients with angina and post-heart attack. Chlorthalidone, a diuretic, effectively reduces fluid retention and lowers blood pressure by promoting sodium and water excretion. Together, they provide an additive antihypertensive effect, with studies indicating no interference in bioavailability when combined. This combination has been proven to lower the risk of cardiovascular events, such as strokes and heart attacks, by effectively managing blood pressure.
Directions for Use
What is the usual dose of combination of Atenolol and Chlorthalidone?
The usual adult daily dose for atenolol is 50 mg, which can be increased to 100 mg if needed. For chlorthalidone, the typical dose is 25 mg daily. When combined in a single tablet, the initial dose is often 50 mg of atenolol and 25 mg of chlorthalidone, taken once a day. If necessary, the dose can be increased to 100 mg of atenolol with 25 mg of chlorthalidone. Both medications are taken orally and are used to manage high blood pressure, with atenolol also addressing angina and post-heart attack survival. The combination provides a convenient dosing regimen for patients requiring both medications.
How does one take combination of Atenolol and Chlorthalidone?
Atenolol and chlorthalidone can be taken with or without food, but it is important to take them at the same time each day to maintain consistent blood levels. There are no specific food restrictions, but patients are advised to follow a low-salt diet to enhance the medication's effectiveness in controlling blood pressure. It's also important to stay hydrated, especially when taking chlorthalidone, as it increases urine output. Patients should consult their doctor for personalized dietary advice and report any unusual symptoms.
For how long is combination of Atenolol and Chlorthalidone taken?
Atenolol and chlorthalidone are typically used as long-term treatments for managing high blood pressure. While atenolol may take 1-2 weeks to show full benefits, both medications are intended for continuous use to maintain blood pressure control. They do not cure hypertension but help manage it, requiring ongoing use even if symptoms improve. Regular monitoring by a healthcare provider is essential to ensure effectiveness and adjust dosages as needed.
How long does it take for combination of Atenolol and Chlorthalidone to work?
Atenolol, a beta-blocker, typically starts to show its effects within 1 to 2 weeks for high blood pressure and angina. Chlorthalidone, a diuretic, begins to work within 2 hours of ingestion, promoting diuresis and reducing blood pressure. When combined, the antihypertensive effects of atenolol and chlorthalidone are additive, providing a more comprehensive approach to lowering blood pressure. The combination may take a few weeks to show full benefits, as the body adjusts to the medication. Both medicines work together to improve blood flow and reduce blood pressure, but their onset times differ slightly due to their unique mechanisms of action.
Warnings and Precautions
Are there harms and risks from taking combination of Atenolol and Chlorthalidone?
Common side effects of atenolol include dizziness, tiredness, and depression, while chlorthalidone may cause muscle weakness, dizziness, and stomach upset. Both medications can lead to low blood pressure and electrolyte imbalances. Serious side effects include shortness of breath, wheezing, and swelling of the extremities. Atenolol may cause bradycardia (slow heart rate), and chlorthalidone can lead to severe skin reactions. Patients should report any severe or persistent side effects to their doctor immediately.
Can I take combination of Atenolol and Chlorthalidone with other prescription drugs?
Atenolol and chlorthalidone can interact with several prescription drugs. Atenolol may interact with calcium channel blockers, leading to increased risk of bradycardia and heart block. Chlorthalidone can interact with lithium, increasing the risk of lithium toxicity. Both medications can interact with other antihypertensives, potentially causing excessive blood pressure reduction. Patients should inform their healthcare provider of all medications they are taking to avoid adverse interactions and ensure safe use.
Can I take combination of Atenolol and Chlorthalidone if I am pregnant?
Atenolol can cross the placental barrier and has been associated with fetal growth restriction when used during pregnancy, particularly in the second trimester. Chlorthalidone, like other diuretics, may cause electrolyte imbalances in the mother and fetus. Both medications should be used during pregnancy only if the potential benefits justify the risks to the fetus. Pregnant women should consult their healthcare provider to carefully weigh the risks and benefits and consider alternative treatments if necessary.
Can I take combination of Atenolol and Chlorthalidone while breastfeeding?
Atenolol is excreted in breast milk and may cause bradycardia and hypoglycemia in breastfed infants, especially in premature or renal-impaired infants. Chlorthalidone also passes into breast milk, but its effects on nursing infants are less well-documented. Caution is advised when administering these medications to breastfeeding mothers. Healthcare providers may recommend monitoring the infant for any adverse effects or considering alternative treatments if necessary. It's important for nursing mothers to discuss the risks and benefits with their healthcare provider.
Who should avoid taking combination of Atenolol and Chlorthalidone?
Atenolol and chlorthalidone are contraindicated in patients with severe bradycardia, heart block, or cardiogenic shock. Atenolol should be used cautiously in patients with asthma or bronchospastic diseases due to its potential to cause bronchospasm. Chlorthalidone is contraindicated in patients with anuria or severe renal impairment. Both medications require caution in patients with diabetes, as they can mask hypoglycemia symptoms. Patients should not abruptly discontinue atenolol, as it may exacerbate angina or cause a heart attack. Regular monitoring and consultation with a healthcare provider are essential to manage these risks.
Forms / Brands
