Aspirin + Metoclopramide
Find more information about this combination medication at the webpages for Aspirin and Metoclopramide
Rheumatoid Arthritis, Pain ... show more
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Advisory
- This medicine contains a combination of 2 drugs Aspirin and Metoclopramide.
- Each of these drugs treats a different disease or symptom.
- Treating different diseases with different medicines allows doctors to adjust the dose of each medicine separately. This prevents overmedication or undermedication.
- Most doctors advise making sure that each individual medicine is safe and effective before using a combination form.
Drug Status
Government Approvals
None
WHO Essential Medicine
NO
Known Teratogen
NO
Pharmaceutical Class
Dopamine-2 Receptor Antagonist and Nonsteroidal Anti-inflammatory Drug and Platelet Aggregation Inhibitor
Controlled Drug Substance
NO
Summary
Aspirin is commonly used to relieve pain, reduce inflammation, and lower fever. It is also used in low doses to prevent heart attacks and strokes by reducing blood clot formation. Metoclopramide is used to treat gastroesophageal reflux, which is a condition where stomach acid frequently flows back into the tube connecting your mouth and stomach, and diabetic gastroparesis, which is a condition that affects the stomach muscles and prevents proper stomach emptying.
Aspirin works by inhibiting the production of prostaglandins, which are substances in the body that cause pain, inflammation, and blood clotting. This helps reduce pain and inflammation and prevents blood clots. Metoclopramide works by enhancing the motility of the upper gastrointestinal tract, which means it increases the movement of the stomach and intestines to help speed up gastric emptying and intestinal transit. It does this by sensitizing tissues to acetylcholine, a neurotransmitter that promotes muscle contractions.
Aspirin is usually taken orally in doses of 300 to 1000 mg every 4 to 6 hours for pain relief, not exceeding 4 grams per day. For cardiovascular protection, a low dose of 81 mg daily is common. Metoclopramide is typically taken orally in doses of 10 to 15 mg four times daily, 30 minutes before meals and at bedtime, with a maximum daily dose of 60 mg for gastroesophageal reflux. For diabetic gastroparesis, the dosage is usually 10 mg four times daily, with a maximum of 40 mg per day.
Common side effects of aspirin include gastrointestinal issues such as nausea, vomiting, and stomach pain, and more severe effects like bleeding and allergic reactions. Metoclopramide can cause restlessness, drowsiness, fatigue, and in some cases, more serious effects like tardive dyskinesia, which is a movement disorder that causes involuntary movements. Both medications can lead to significant adverse effects if not used properly, so it's important to follow dosing instructions carefully.
Aspirin should not be used in individuals with a history of bleeding disorders, peptic ulcers, or aspirin allergy. It can increase the risk of gastrointestinal bleeding, especially when used with other NSAIDs or anticoagulants. Metoclopramide is contraindicated in patients with a history of tardive dyskinesia, gastrointestinal obstruction, or pheochromocytoma, which is a rare tumor of adrenal gland tissue. Both drugs should be used with caution in individuals with a history of gastrointestinal issues, and alcohol consumption should be limited to reduce the risk of stomach bleeding.
Indications and Purpose
How does combination of Aspirin and Metoclopramide work?
The combination of Aspirin and Metoclopramide is often used to treat migraines. Aspirin is a type of medication known as a non-steroidal anti-inflammatory drug (NSAID). It works by reducing substances in the body that cause pain and inflammation. Metoclopramide, on the other hand, is a medication that helps with nausea and vomiting. It works by blocking a chemical in the brain that causes nausea and by speeding up the movement of the stomach and intestines, which helps with digestion. Together, these medications can help relieve the headache pain and associated nausea that often accompany migraines.
How does combination of Metoclopramide and Aspirin work?
Metoclopramide works by enhancing the motility of the upper gastrointestinal tract, increasing the movement of the stomach and intestines to facilitate gastric emptying and intestinal transit. It acts by sensitizing tissues to acetylcholine, a neurotransmitter that promotes muscle contractions. Aspirin, on the other hand, inhibits the production of prostaglandins, substances that cause pain, inflammation, and blood clotting, thereby reducing these symptoms. Both drugs are absorbed in the gastrointestinal tract and have systemic effects, but they target different pathways to achieve their therapeutic outcomes.
How effective is combination of Aspirin and Metoclopramide?
The combination of Aspirin and Metoclopramide is often used to treat migraines. Aspirin is a pain reliever that helps reduce inflammation and pain, while Metoclopramide is used to help with nausea and vomiting that can accompany migraines. According to the NHS, this combination can be effective in providing relief from migraine symptoms. However, it's important to use these medications as directed by a healthcare professional to ensure safety and effectiveness. Always consult with a doctor or pharmacist before starting any new medication regimen.
How effective is combination of Metoclopramide and Aspirin?
Metoclopramide's effectiveness is supported by its ability to enhance gastric motility, providing relief for conditions like gastroesophageal reflux and diabetic gastroparesis. Clinical studies have shown its efficacy in improving gastric emptying and reducing symptoms like nausea. Aspirin's effectiveness is well-documented in reducing pain, inflammation, and preventing cardiovascular events. It works by inhibiting prostaglandin synthesis, which is crucial in pain and inflammation pathways. Both drugs have a long history of use, with substantial clinical evidence supporting their respective roles in managing gastrointestinal and cardiovascular conditions.
Directions for Use
What is the usual dose of combination of Aspirin and Metoclopramide?
The usual dose of the combination of Aspirin and Metoclopramide for treating migraines is typically one tablet containing 900 mg of Aspirin and 10 mg of Metoclopramide. This combination helps relieve headache pain and nausea. However, it's important to follow the specific dosage instructions provided by a healthcare professional or the medication's packaging, as individual needs may vary. Always consult with a healthcare provider before starting any new medication.
What is the usual dose of combination of Metoclopramide and Aspirin?
For metoclopramide, the usual adult dosage for gastroesophageal reflux is 10 to 15 mg taken four times daily, 30 minutes before meals and at bedtime, with a maximum daily dose of 60 mg. For diabetic gastroparesis, the dosage is typically 10 mg four times daily, with a maximum of 40 mg per day. Aspirin, when used for pain relief or anti-inflammatory purposes, is often taken in doses of 300 to 1000 mg every 4 to 6 hours, not exceeding 4 g per day. For cardiovascular protection, a low dose of 81 mg daily is common. Both medications require careful adherence to dosing schedules to avoid adverse effects.
How does one take combination of Aspirin and Metoclopramide?
Aspirin and Metoclopramide are sometimes used together to treat certain conditions like migraines. Aspirin is a pain reliever and anti-inflammatory, while Metoclopramide helps with nausea and vomiting. When taking these medications together, it's important to follow the dosage instructions provided by your healthcare provider or the information on the medication packaging. Typically, Aspirin is taken orally with water, and Metoclopramide is also taken by mouth, usually 30 minutes before meals and at bedtime. Always check with a healthcare professional before starting this combination to ensure it's safe for you, especially if you have other health conditions or are taking other medications. For more detailed information, you can visit trusted sources like the [NHS](https://www.nhs.uk/) or [NLM](https://www.nlm.nih.gov/).
How does one take combination of Metoclopramide and Aspirin?
Metoclopramide should be taken 30 minutes before meals and at bedtime to optimize its effect on gastric motility. Aspirin can be taken with food or a full glass of water to minimize gastrointestinal discomfort. Both medications should be used with caution in individuals with a history of gastrointestinal issues, and alcohol consumption should be limited to reduce the risk of stomach bleeding. It's important to follow dosing instructions carefully and consult a healthcare provider for any dietary restrictions or interactions.
For how long is combination of Aspirin and Metoclopramide taken?
The combination of Aspirin and Metoclopramide is typically used for the treatment of acute migraine attacks. According to the NHS, this combination is usually taken as a single dose at the onset of a migraine. If needed, a second dose can be taken, but it should not be used for more than two days in a row without consulting a healthcare professional. It's important to follow the specific dosage instructions provided by your doctor or pharmacist.
For how long is combination of Metoclopramide and Aspirin taken?
Metoclopramide is typically used for short-term treatment, not exceeding 12 weeks, due to the risk of developing tardive dyskinesia with prolonged use. Aspirin can be used both short-term for pain relief and long-term for cardiovascular protection, depending on the condition being treated. While metoclopramide's use is limited by potential side effects, aspirin's duration of use is more flexible, often determined by the therapeutic goal, such as ongoing prevention of heart attacks or strokes.
How long does it take for combination of Aspirin and Metoclopramide to work?
The combination of Aspirin and Metoclopramide is often used to treat migraines. According to the NHS, this combination can start to relieve symptoms within 30 minutes to 1 hour after taking it. Aspirin works by reducing pain and inflammation, while Metoclopramide helps with nausea and enhances the absorption of Aspirin, making it more effective.
How long does it take for combination of Metoclopramide and Aspirin to work?
Metoclopramide typically begins to work within 30 to 60 minutes after oral administration, as it is absorbed and starts to affect gastrointestinal motility. Aspirin, on the other hand, can start to relieve pain and reduce fever within 15 to 30 minutes when taken orally. Both medications are absorbed in the gastrointestinal tract, but metoclopramide's primary action is to enhance gastric emptying and intestinal transit, while aspirin works by inhibiting substances that cause pain and inflammation. The onset of action for both drugs is relatively quick, making them effective for their respective uses.
Warnings and Precautions
Are there harms and risks from taking combination of Aspirin and Metoclopramide?
Taking Aspirin and Metoclopramide together can have potential risks and side effects. Aspirin is a medication used to relieve pain, reduce inflammation, and lower fever. Metoclopramide is used to treat nausea and vomiting, and it works by increasing the movements or contractions of the stomach and intestines. When taken together, these medications can increase the risk of gastrointestinal issues, such as stomach ulcers or bleeding, because both can irritate the stomach lining. Aspirin, in particular, is known to increase the risk of bleeding, and Metoclopramide can enhance this effect. It's important to consult with a healthcare professional before combining these medications to ensure it's safe based on your individual health needs and conditions. They can provide guidance on the appropriate dosages and monitor for any adverse effects.
Are there harms and risks from taking combination of Metoclopramide and Aspirin?
Common side effects of metoclopramide include restlessness, drowsiness, fatigue, and in some cases, more serious effects like tardive dyskinesia, a movement disorder. Aspirin can cause gastrointestinal issues such as nausea, vomiting, and stomach pain, and more severe effects like bleeding and allergic reactions. Both medications can lead to significant adverse effects if not used properly, highlighting the importance of adhering to prescribed dosages and monitoring for any unusual symptoms. Patients should be aware of these potential side effects and consult healthcare providers if they experience any concerning reactions.
Can I take combination of Aspirin and Metoclopramide with other prescription drugs?
When considering taking Aspirin and Metoclopramide with other prescription drugs, it's important to be aware of potential interactions. Aspirin is a medication used to relieve pain, reduce inflammation, and lower fever. It can also thin the blood, which is why it's sometimes used to prevent heart attacks and strokes. However, because it affects blood clotting, it can interact with other medications that also affect bleeding, such as anticoagulants (blood thinners). Metoclopramide is used to treat nausea and vomiting, and it works by increasing the movements or contractions of the stomach and intestines. It can interact with medications that affect the central nervous system, such as sedatives or antidepressants, potentially increasing side effects like drowsiness. Before taking these medications with other prescription drugs, it's crucial to consult with a healthcare professional. They can provide guidance based on your specific health needs and the other medications you are taking. This ensures that you avoid harmful interactions and manage your health safely. For more detailed information, you can visit trusted sources like the [NHS](https://www.nhs.uk/), [DailyMeds](https://dailymeds.co.uk/), or [NLM](https://www.nlm.nih.gov/).
Can I take combination of Metoclopramide and Aspirin with other prescription drugs?
Metoclopramide can interact with drugs that affect the central nervous system, such as antipsychotics, increasing the risk of extrapyramidal symptoms. It also interacts with CYP2D6 inhibitors, which can increase metoclopramide levels. Aspirin interacts with anticoagulants like warfarin, increasing bleeding risk, and with other NSAIDs, which can enhance gastrointestinal side effects. Both drugs require careful monitoring when used with medications that affect blood clotting or the central nervous system, and healthcare providers should be informed of all medications being taken to manage these interactions effectively.
Can I take combination of Aspirin and Metoclopramide if I am pregnant?
It is generally not recommended to take Aspirin during pregnancy, especially in the later stages, as it can affect the baby's development and increase the risk of complications. Metoclopramide is sometimes used during pregnancy to treat nausea and vomiting, but it should only be taken if prescribed by a healthcare professional who has assessed the benefits and risks. Always consult with your doctor or a healthcare provider before taking any medication during pregnancy to ensure it is safe for you and your baby.
Can I take combination of Metoclopramide and Aspirin if I am pregnant?
Metoclopramide crosses the placental barrier and may cause extrapyramidal signs in neonates if used during delivery. Aspirin, especially in doses greater than 81 mg, can harm the fetus and cause complications during delivery if taken after 20 weeks of pregnancy. Both medications should be used with caution during pregnancy, and only if the potential benefits justify the risks to the fetus. Pregnant women should consult their healthcare provider before using these medications to ensure safety for both mother and child.
Can I take combination of Aspirin and Metoclopramide while breastfeeding?
When considering taking Aspirin and Metoclopramide while breastfeeding, it's important to understand the potential effects on both the mother and the baby. Aspirin is a medication commonly used to relieve pain, reduce inflammation, and lower fever. However, it can pass into breast milk and may affect the baby. According to the NHS, regular use of Aspirin while breastfeeding is generally not recommended due to the risk of Reye's syndrome, a rare but serious condition that can affect the liver and brain of children. Metoclopramide is a medication used to treat nausea and vomiting. According to the NLM, it is generally considered safe for short-term use during breastfeeding, as only small amounts pass into breast milk and it is unlikely to harm the baby. Before taking any medication, including a combination of Aspirin and Metoclopramide, it is crucial to consult with a healthcare professional to weigh the benefits and risks and to explore safer alternatives if necessary.
Can I take combination of Metoclopramide and Aspirin while breastfeeding?
Metoclopramide is present in breast milk and may cause gastrointestinal side effects in the infant, such as intestinal discomfort. Aspirin is also excreted in breast milk and can pose risks such as Reye's syndrome in infants. Both medications should be used with caution during breastfeeding, and the potential benefits should be weighed against the risks. Mothers should consult their healthcare provider to discuss the safety of these medications while breastfeeding and consider alternative treatments if necessary.
Who should avoid taking combination of Aspirin and Metoclopramide?
People who should avoid taking a combination of Aspirin and Metoclopramide include those with certain medical conditions or who are taking specific medications. According to trusted sources like the NHS and NLM, individuals with a history of stomach ulcers, bleeding disorders, or severe liver or kidney problems should avoid this combination. Additionally, those who are allergic to Aspirin or Metoclopramide should not take these drugs together. Pregnant or breastfeeding women should also consult a healthcare professional before using these medications. It's important to discuss with a doctor if you are taking other medications, as there could be interactions that increase the risk of side effects.
Who should avoid taking combination of Metoclopramide and Aspirin?
Metoclopramide is contraindicated in patients with a history of tardive dyskinesia, gastrointestinal obstruction, or pheochromocytoma due to the risk of exacerbating these conditions. Aspirin should not be used in individuals with a history of bleeding disorders, peptic ulcers, or aspirin allergy. Both drugs carry a risk of gastrointestinal bleeding, especially in the elderly or those with a history of ulcers. Patients should be aware of these risks and consult their healthcare provider before starting these medications, particularly if they have pre-existing health conditions that could be aggravated by these drugs.
