Alvimopan
Postoperative Complications
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Opioid Antagonist
Controlled Drug Substance
No
alvimopan
Summary
Alvimopan is used to help bowel recovery after surgery, which refers to the process of restoring normal bowel function. It is particularly beneficial for patients undergoing bowel surgery, as it helps reduce the time to bowel recovery and shortens hospital stays.
Alvimopan works by blocking the effects of opioids on the gut, which are substances that can slow down bowel movements. It acts on specific receptors in the digestive system, allowing the bowel to move properly and aiding in quicker recovery after surgery.
The usual dose of Alvimopan for adults is 12 mg taken 30 minutes to 5 hours before surgery, followed by 12 mg twice daily for up to 7 days or until discharge. It is taken as a capsule, which is a small, solid form of medication.
Common side effects of Alvimopan include nausea, which is a feeling of sickness with an inclination to vomit, vomiting, and flatulence, which refers to the accumulation of gas in the digestive system. These effects are generally mild and occur occasionally.
Alvimopan should not be used by people who have taken opioids for more than 7 consecutive days before starting it, due to increased risk of side effects. It is also contraindicated in people with severe liver impairment, which refers to significant liver damage.
Indications and Purpose
How does Alvimopan work?
Alvimopan works by blocking the effects of opioids on the gut. Normally, opioids can slow down bowel movements, but Alvimopan prevents this by acting on specific receptors in the digestive system. Think of it like a key that unlocks the bowel's normal function, allowing it to move properly. This helps patients recover bowel function after surgery more quickly.
Is Alvimopan effective?
Alvimopan is effective for helping bowel recovery after surgery. It works by blocking certain effects of opioids on the gut, which helps restore normal bowel function. Clinical studies show that Alvimopan can reduce the time to bowel recovery and shorten hospital stays. This makes it a valuable option for patients undergoing bowel surgery. Always follow your doctor's instructions to achieve the best results.
What is Alvimopan?
Alvimopan is a medication used to help bowel recovery after surgery. It belongs to a class of drugs called peripherally acting mu-opioid receptor antagonists. Alvimopan works by blocking the effects of opioids on the gut, which helps restore normal bowel function. It's primarily used in hospitals for patients undergoing bowel surgery. Alvimopan is not used for pain relief or other conditions.
Directions for Use
For how long do I take Alvimopan?
Alvimopan is used short-term for bowel recovery after surgery. It's typically taken for up to 7 days or until discharge from the hospital. The duration of use may vary based on your specific medical needs and your doctor's recommendations. Always follow your doctor's instructions regarding the length of time you should take Alvimopan.
How do I dispose of Alvimopan?
If you can, bring unused Alvimopan to a drug take-back program or collection site at a pharmacy or hospital. They will dispose of this medicine properly so it doesn't harm people or the environment. If you can't find a take-back program, you can throw most medicines in the trash at home. But first, take them out of their original containers, mix them with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Alvimopan?
Alvimopan is usually taken as a capsule before surgery to help with bowel recovery. It's typically given in a hospital setting. You should not crush or chew the capsule. Alvimopan is taken with or without food. If you miss a dose, inform your healthcare provider. There are no specific dietary or beverage restrictions, but always follow your doctor's advice. Avoid taking two doses at once. Always consult your healthcare provider for specific instructions related to your treatment.
How long does it take for Alvimopan to start working?
Alvimopan begins working shortly after you take it, helping to restore bowel function after surgery. The time to achieve full therapeutic effect can vary, but many patients notice improvements within a few days. Factors like your overall health and the type of surgery can affect how quickly Alvimopan works. Always follow your doctor's instructions for the best results.
How should I store Alvimopan?
Store Alvimopan at room temperature, away from moisture and light. Keep it in its original container, tightly closed. Do not store it in the bathroom, where humidity can affect the medication. Always keep Alvimopan out of reach of children to prevent accidental ingestion. Check the expiration date regularly and dispose of any unused or expired medication properly.
What is the usual dose of Alvimopan?
The usual dose of Alvimopan for adults is 12 mg taken 30 minutes to 5 hours before surgery, followed by 12 mg twice daily for up to 7 days or until discharge. It's important to follow your doctor's specific dosing instructions. Alvimopan is not recommended for long-term use. Dose adjustments may be necessary for special populations, so always consult your healthcare provider for personalized advice.
Warnings and Precautions
Can Alvimopan be taken safely while breastfeeding?
The safety of Alvimopan while breastfeeding is not well-established. It's unclear if the medication passes into breast milk. If you're breastfeeding or planning to breastfeed, discuss with your doctor whether Alvimopan is appropriate for you. Your doctor can help determine the best treatment options to ensure the safety of both you and your baby.
Can Alvimopan be taken safely while pregnant?
The safety of Alvimopan during pregnancy is not well-established. There is limited evidence to provide definitive advice. It's important to weigh the potential benefits against the risks. If you're pregnant or planning to become pregnant, talk with your doctor about the safest options for your treatment. Your doctor can help create a plan that protects both you and your baby.
Can I take Alvimopan with other prescription drugs?
Alvimopan has no major drug interactions, but it should not be used with opioids, as this can increase the risk of side effects. Always inform your doctor about all medications you are taking to avoid potential interactions. Your doctor can help ensure that Alvimopan is safe and effective for you.
Does Alvimopan have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Alvimopan include nausea, vomiting, and flatulence. These effects are generally mild. Serious adverse effects are rare but can include cardiovascular events. If you experience severe symptoms like chest pain or difficulty breathing, seek medical attention immediately. Always inform your doctor about any new or worsening symptoms while taking Alvimopan.
Does Alvimopan have any safety warnings?
Yes, Alvimopan has important safety warnings. It is not recommended for people who have taken opioids for more than 7 consecutive days before starting Alvimopan, as it may increase the risk of serious side effects. Alvimopan can cause cardiovascular events, so it's important to monitor for symptoms like chest pain or shortness of breath. Not adhering to these warnings can lead to serious health risks. Always follow your doctor's instructions and report any concerning symptoms immediately.
Is Alvimopan addictive?
Alvimopan is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Alvimopan works by affecting the digestive system to help with bowel recovery after surgery. It doesn't affect brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, you can feel confident that Alvimopan doesn't carry this risk.
Is Alvimopan safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Alvimopan, such as cardiovascular events. It's important to monitor for symptoms like chest pain or shortness of breath. Alvimopan can be used safely in the elderly with careful monitoring. Always consult your doctor to ensure the medication is appropriate for you, considering your age and overall health.
Is it safe to drink alcohol while taking Alvimopan?
It's best to avoid alcohol while taking Alvimopan. Alcohol can increase the risk of side effects like dizziness or low blood pressure. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like dizziness or nausea. Talk with your doctor about alcohol use while taking Alvimopan to get personalized advice based on your specific health situation.
Is it safe to exercise while taking Alvimopan?
You can exercise while taking Alvimopan, but keep a few things in mind. This medication can cause dizziness, so be cautious during physical activity. If you feel dizzy or lightheaded, slow down or stop exercising and rest. Drink plenty of water before, during, and after exercise to stay hydrated. Most people can maintain their regular exercise routine while taking Alvimopan, but check with your doctor if you have concerns.
Is it safe to stop Alvimopan?
Alvimopan is typically used short-term for bowel recovery after surgery. Stopping it before the usual duration may affect recovery. There are no known withdrawal symptoms, but always consult your doctor before stopping. Your doctor can guide you on safely discontinuing the medication and ensure your recovery process is not compromised.
What are the most common side effects of Alvimopan?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Alvimopan include nausea, vomiting, and flatulence. These effects are generally mild and occur in a small percentage of people. If you notice new symptoms after starting Alvimopan, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Alvimopan?
Alvimopan should not be used by people who have taken opioids for more than 7 consecutive days before starting it, due to increased risk of side effects. It's also contraindicated in people with severe liver impairment. Caution is needed for those with cardiovascular disease. Always consult your doctor to ensure Alvimopan is safe for you, considering your medical history and current medications.
