Alitretinoin
Kaposi Sarcoma, Skin Diseases
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Retinoid
Controlled Drug Substance
No
Summary
Alitretinoin is used to treat severe chronic hand eczema, which is a skin condition causing redness, itching, and scaling, that doesn't respond to other treatments.
Alitretinoin works by reducing inflammation, which is the body's response to injury or infection, and controlling skin cell growth, helping to improve the skin's condition.
The usual starting dose of alitretinoin for adults is 30 mg taken once daily with a meal. The capsule should be swallowed whole with water.
Common side effects of alitretinoin include dry skin, lips, and eyes, which are usually mild and manageable with moisturizers and eye drops.
Alitretinoin can cause birth defects, so it must not be used during pregnancy. It is also contraindicated in people with liver disease or high blood lipid levels, which are fats in the blood.
Indications and Purpose
How does alitretinoin work?
Alitretinoin works by reducing inflammation and controlling skin cell growth. It belongs to a class of drugs called retinoids, which are related to vitamin A. Think of it like a gardener trimming overgrown plants to keep them healthy. Alitretinoin helps manage severe chronic hand eczema by improving skin condition.
Is alitretinoin effective?
Alitretinoin is effective for treating severe chronic hand eczema that doesn't respond to other treatments. Clinical studies show significant improvement in skin condition among users. It works by reducing inflammation and controlling skin cell growth. Regular follow-ups with your doctor can help monitor your progress and adjust treatment as needed.
What is alitretinoin?
Alitretinoin is a medication used to treat severe chronic hand eczema that doesn't respond to other treatments. It belongs to a class of drugs called retinoids, which are related to vitamin A. Alitretinoin works by reducing inflammation and controlling skin cell growth, helping to improve the condition of the skin.
Directions for Use
For how long do I take alitretinoin?
Alitretinoin is usually taken for a specific duration to treat severe chronic hand eczema. The treatment course typically lasts 12 to 24 weeks, depending on your response. Your doctor will determine the appropriate duration based on your condition and progress. Always follow your doctor's instructions and complete the full course of treatment.
How do I dispose of alitretinoin?
Dispose of unused alitretinoin by taking it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away.
How do I take alitretinoin?
Alitretinoin is usually taken once daily with a meal. Swallow the capsule whole with water; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Follow your doctor's specific instructions regarding diet and fluid intake while on this medication.
How long does it take for alitretinoin to start working?
Alitretinoin may start showing improvements in your skin condition within a few weeks, but it can take up to 12 weeks to see the full benefits. The time it takes to work can vary based on individual factors like the severity of your eczema and your overall health. Follow your doctor's instructions for the best results.
How should I store alitretinoin?
Store alitretinoin capsules at room temperature, away from moisture and light. Keep them in a tightly closed container. Don't store your medicine in humid places like bathrooms. Always store alitretinoin out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of alitretinoin?
The usual starting dose of alitretinoin for adults is 30 mg once daily with a meal. Your doctor may adjust your dose based on your response to the treatment. The maximum recommended dose is 30 mg per day. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can alitretinoin be taken safely while breastfeeding?
Alitretinoin is not recommended while breastfeeding. It is unknown if the medication passes into breast milk, but it may pose risks to the infant. If you're taking alitretinoin and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely.
Can alitretinoin be taken safely while pregnant?
Alitretinoin is not safe during pregnancy due to the risk of birth defects. Women of childbearing age must use effective contraception while taking this medication. If you become pregnant while on alitretinoin, stop taking it immediately and contact your doctor for guidance.
Can I take alitretinoin with other prescription drugs?
Alitretinoin can interact with certain medications, increasing the risk of side effects. Avoid using it with tetracycline antibiotics, which can increase the risk of increased pressure in the brain. Always inform your doctor about all medications you're taking to prevent interactions and ensure safe treatment.
Does alitretinoin have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of alitretinoin include dry skin, lips, and eyes. These effects are usually mild. Serious side effects can include liver problems and increased blood lipid levels. If you notice any new or worsening symptoms, contact your doctor. Regular monitoring can help manage these effects.
Does alitretinoin have any safety warnings?
Alitretinoin has important safety warnings. It can cause birth defects, so it must not be used during pregnancy. Women of childbearing age should use effective contraception. Alitretinoin can also increase blood lipid levels, which are fats in your blood, and may affect liver function. Regular blood tests are needed to monitor these levels. If you experience any unusual symptoms, contact your doctor immediately.
Is alitretinoin addictive?
Alitretinoin is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. If you have concerns about medication dependence, you can feel confident that alitretinoin doesn't carry this risk while managing your health condition.
Is alitretinoin safe for the elderly?
Elderly individuals may be more vulnerable to the side effects of alitretinoin, such as liver problems and increased blood lipid levels. Regular monitoring and dose adjustments may be necessary. Always consult your doctor before starting alitretinoin to ensure it's safe for your specific health needs.
Is it safe to drink alcohol while taking alitretinoin?
It's best to avoid alcohol while taking alitretinoin. Alcohol can increase the risk of liver problems, which are a potential side effect of alitretinoin. If you do choose to drink occasionally, limit how much alcohol you consume and watch for warning signs like nausea or abdominal pain. Talk with your doctor about alcohol use while taking alitretinoin.
Is it safe to exercise while taking alitretinoin?
You can exercise while taking alitretinoin, but keep a few things in mind. This medication can cause dry skin and lips, which might be uncomfortable during physical activity. Stay hydrated and use moisturizers to manage these effects. If you notice any unusual symptoms during exercise, slow down or stop and rest. Consult your doctor if you have concerns.
Is it safe to stop alitretinoin?
Alitretinoin is usually used for a specific duration to treat conditions like severe eczema. Stopping it suddenly may cause your symptoms to return. Always talk with your doctor before stopping alitretinoin. They might suggest gradually reducing your dose or switching to a different medication to keep your condition under control.
What are the most common side effects of alitretinoin?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of alitretinoin include dry skin, lips, and eyes. These effects are usually mild and manageable with moisturizers and eye drops. If you notice new symptoms after starting alitretinoin, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking alitretinoin?
Alitretinoin must not be used during pregnancy due to the risk of birth defects. Women of childbearing age should use effective contraception. It is also contraindicated in people with liver disease or high blood lipid levels. Always consult your doctor about these concerns before starting alitretinoin.
