Afatinib dimaleate
Non-Small-Cell Lung Carcinoma, Squamous Cell Carcinoma
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
YES
Known Teratogen
Definite
Pharmaceutical Class
Kinase Inhibitor
Controlled Drug Substance
No
Afatinib dimaleate
Summary
Afatinib dimaleate is used to treat non-small cell lung cancer, which is a type of cancer affecting the lungs. It is specifically used when the cancer has certain genetic mutations, which are changes in the DNA that can affect how cells grow.
Afatinib dimaleate works by blocking proteins called tyrosine kinases, which help cancer cells grow and spread. By stopping these proteins, it slows down or stops the growth of cancer cells, helping to manage the disease.
The usual starting dose of Afatinib dimaleate for adults is 40 mg taken once daily. It is taken by mouth, preferably in the morning on an empty stomach, which means at least one hour before or two hours after a meal.
Common side effects of Afatinib dimaleate include diarrhea, which is frequent loose or watery stools, skin rash, which is an area of irritated or swollen skin, and mouth sores, which are painful ulcers in the mouth.
Afatinib dimaleate should not be taken if you are allergic to it. It can cause severe diarrhea, skin reactions, and lung problems. Avoid grapefruit, which can affect how the medicine works, and consult your doctor if you have liver or kidney issues.
Indications and Purpose
How does Afatinib dimaleate work?
Afatinib dimaleate works by blocking proteins called tyrosine kinases, which help cancer cells grow and spread. Think of it like turning off a switch that powers cancer cell growth. By inhibiting these proteins, Afatinib dimaleate slows down or stops the growth of cancer cells. This helps manage certain types of cancer, such as non-small cell lung cancer, and can improve patient outcomes.
Is Afatinib dimaleate effective?
Afatinib dimaleate is effective for treating certain types of cancer, such as non-small cell lung cancer. It works by blocking proteins that help cancer cells grow. Clinical studies show that Afatinib dimaleate can improve survival rates and delay disease progression in patients with specific genetic mutations. Your doctor will monitor your response to the medication to ensure it's working effectively for your condition.
What is Afatinib dimaleate?
Afatinib dimaleate is a medication used to treat certain types of cancer, such as non-small cell lung cancer. It belongs to a class of drugs called tyrosine kinase inhibitors, which work by blocking proteins that help cancer cells grow. This medication is used when cancer has specific genetic mutations. Afatinib dimaleate is usually taken as a long-term treatment to manage cancer progression.
Directions for Use
For how long do I take Afatinib dimaleate?
Afatinib dimaleate is usually taken long-term for managing certain types of cancer. The duration of use depends on your response to treatment and any side effects you experience. Your doctor will monitor your condition and adjust your treatment plan as needed. Always talk with your doctor before changing or stopping your Afatinib dimaleate treatment.
How do I dispose of Afatinib dimaleate?
Dispose of Afatinib dimaleate by taking it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and throw it away. This helps prevent harm to people and the environment.
How do I take Afatinib dimaleate?
Take Afatinib dimaleate once daily, preferably in the morning. Swallow the tablet whole with water on an empty stomach, at least one hour before or two hours after a meal. Do not crush or chew the tablet. If you miss a dose, take it as soon as you remember unless it's close to your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Avoid grapefruit and grapefruit juice while taking this medication, as they can affect how the medicine works.
How long does it take for Afatinib dimaleate to start working?
Afatinib dimaleate starts working in your body shortly after you take it, but the full therapeutic effects may take weeks to become noticeable. The time it takes to see results can vary based on individual factors like your overall health and the specific type of cancer being treated. Regular check-ups and tests with your doctor will help monitor the medication's effectiveness.
How should I store Afatinib dimaleate?
Store Afatinib dimaleate at room temperature, away from moisture and light. Keep it in its original container with the lid tightly closed. Do not store it in the bathroom, where humidity can affect the medication. Keep it out of reach of children and pets. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Afatinib dimaleate?
The usual starting dose of Afatinib dimaleate for adults is 40 mg once daily. Your doctor may adjust the dose based on your response and any side effects. The maximum recommended dose is 50 mg daily. Dose adjustments may be necessary for elderly patients or those with specific health conditions. Always follow your doctor's specific dosing instructions for your personal health needs.
Warnings and Precautions
Can Afatinib dimaleate be taken safely while breastfeeding?
Afatinib dimaleate is not recommended while breastfeeding. It's unclear if it passes into human breast milk, but it could pose risks to a nursing infant. If you're taking Afatinib dimaleate and want to breastfeed, talk with your doctor about safer medication options. Your doctor can help you make informed decisions to ensure your baby's safety.
Can Afatinib dimaleate be taken safely while pregnant?
Afatinib dimaleate is not recommended during pregnancy. It can harm an unborn baby. There is limited information on its use in pregnant women, but animal studies show potential risks. If you're pregnant or planning to become pregnant, talk with your doctor about safer treatment options. Your doctor can help create a plan that protects both you and your baby.
Can I take Afatinib dimaleate with other prescription drugs?
Afatinib dimaleate can interact with certain medications, increasing the risk of side effects or reducing effectiveness. Avoid using it with strong CYP3A4 inhibitors, which are drugs that affect liver enzymes, as they can increase Afatinib levels in your body. Also, be cautious with P-gp inhibitors, which can affect drug transport in your body. Always inform your doctor about all medications you're taking to prevent interactions.
Does Afatinib dimaleate have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Afatinib dimaleate include diarrhea, skin rash, and mouth sores. These effects can vary in frequency and severity. Serious side effects like lung problems or severe skin reactions require immediate medical attention. Always inform your doctor about any new or worsening symptoms while taking this medication to ensure your treatment is safe and effective.
Does Afatinib dimaleate have any safety warnings?
Yes, Afatinib dimaleate has important safety warnings. It can cause severe diarrhea, skin reactions, and lung problems. If you experience severe diarrhea, skin rash, or breathing difficulties, contact your doctor immediately. These side effects can be serious and require prompt medical attention. It's crucial to follow your doctor's instructions and report any new or worsening symptoms while taking this medication.
Is Afatinib dimaleate addictive?
Afatinib dimaleate is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. This medication works by targeting specific proteins in cancer cells and does not affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, you can feel confident that Afatinib dimaleate doesn't carry this risk.
Is Afatinib dimaleate safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Afatinib dimaleate, such as diarrhea and skin reactions. These side effects can be more severe in older adults. It's important for elderly patients to be closely monitored by their healthcare provider while taking this medication. Dose adjustments may be necessary based on individual health conditions and response to treatment.
Is it safe to drink alcohol while taking Afatinib dimaleate?
It's best to avoid alcohol while taking Afatinib dimaleate. Alcohol can increase the risk of side effects like dehydration and liver problems. If you choose to drink occasionally, limit your alcohol intake and watch for warning signs like nausea or dizziness. Talk with your doctor about alcohol use while taking Afatinib dimaleate for personalized advice.
Is it safe to exercise while taking Afatinib dimaleate?
You can exercise while taking Afatinib dimaleate, but be cautious. This medication can cause side effects like fatigue and dehydration, which might affect your exercise capacity. To exercise safely, drink plenty of water and listen to your body. If you feel dizzy or unusually tired, slow down or stop exercising and rest. Consult your doctor if you have concerns about your specific situation.
Is it safe to stop Afatinib dimaleate?
Stopping Afatinib dimaleate suddenly can affect your treatment. It's used for long-term management of certain cancers. Stopping without medical advice could worsen your condition. Always talk with your doctor before stopping Afatinib dimaleate. They might suggest a gradual reduction or alternative treatment to keep your condition under control. Your doctor will help you make any medication changes safely.
What are the most common side effects of Afatinib dimaleate?
Side effects are unwanted reactions that can occur with medication use. Common side effects of Afatinib dimaleate include diarrhea, skin rash, and mouth sores. These side effects can vary in frequency and severity. If you experience new symptoms after starting Afatinib dimaleate, they might be temporary or unrelated to the medication. Always talk with your doctor before stopping any medication.
Who should avoid taking Afatinib dimaleate?
Do not take Afatinib dimaleate if you're allergic to it or its ingredients. Serious allergic reactions require immediate medical help. This medication is not recommended for people with severe liver problems. Caution is needed for those with kidney issues or a history of lung disease. Always consult your doctor about these concerns to ensure safe use of Afatinib dimaleate.
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