Adefovir
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Drug Status
Government Approvals
US(FDA)
WHO Essential Medicine
NO
Known Teratogen
No
Pharmaceutical Class
Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
Controlled Drug Substance
No
Adefovir
Summary
Adefovir is used to treat chronic hepatitis B infection in adults and children aged 12 years and older. It helps to manage the infection and improve liver function but it is not a cure for hepatitis B.
Adefovir is a nucleotide analog. It works by inhibiting the replication of the hepatitis B virus, thereby decreasing the amount of virus in the body and helping to manage the infection and improve liver function.
The usual daily dose of Adefovir for adults and children aged 12 years and older is 10 mg taken once daily. It is not recommended for use in children under 12 years of age.
Common side effects of Adefovir include weakness, headache, diarrhea, gas, indigestion, sore throat, runny nose, and rash. Serious adverse effects include kidney damage, lactic acidosis, and liver damage.
Important warnings for Adefovir include the risk of severe acute exacerbations of hepatitis after discontinuation, nephrotoxicity, HIV resistance, and lactic acidosis. It is contraindicated in patients with hypersensitivity to any of its components. Patients should be monitored closely for liver and kidney function during treatment.
Indications and Purpose
How does Adefovir work?
Adefovir works by inhibiting the replication of the hepatitis B virus, which is a virus that infects the liver. It does this by blocking an enzyme the virus needs to multiply. Think of it like putting a lock on a door to prevent the virus from entering and spreading. This helps reduce the amount of virus in the body and improves liver function.
Is Adefovir effective?
Adefovir is effective in treating chronic hepatitis B, which is a viral infection that affects the liver. It works by reducing the amount of virus in the body, which helps improve liver function and slow the progression of the disease. Clinical studies show that Adefovir effectively lowers viral load and improves liver health in patients with hepatitis B.
What is Adefovir?
Adefovir is an antiviral medication used to treat chronic hepatitis B, which is a viral infection that affects the liver. It works by reducing the amount of virus in the body, which helps improve liver function and slow the progression of the disease. Adefovir is usually used as part of a combination therapy with other medications.
Directions for Use
For how long do I take Adefovir?
Adefovir is usually a long-term medication for managing chronic hepatitis B. You'll typically take it every day as a lifelong treatment unless your doctor suggests otherwise. Stopping this medication without medical advice could cause your condition to worsen. Always talk with your doctor before changing or stopping your Adefovir treatment.
How do I dispose of Adefovir?
Dispose of Adefovir by taking it to a drug take-back program or collection site at a pharmacy or hospital. If you can't find a take-back program, you can throw it in the trash at home. First, take it out of its original container, mix it with something undesirable like used coffee grounds, seal the mixture in a plastic bag, and throw it away.
How do I take Adefovir?
Take Adefovir exactly as prescribed by your doctor. It's usually taken once daily, with or without food. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember unless it's almost time for your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Always follow your doctor's specific instructions.
How long does it take for Adefovir to start working?
Adefovir begins working in your body shortly after you take it, but you may not notice all the benefits right away. It can take several months to see significant improvements in liver function and viral load. Regular check-ups with your doctor are important to monitor your progress and ensure the medication is working effectively.
How should I store Adefovir?
Store Adefovir at room temperature, away from moisture and light. Keep it in a tightly closed container. Don't store it in humid places like bathrooms, where moisture could affect the medication. Always store Adefovir out of children's reach to prevent accidental swallowing. Check the expiration date regularly and properly dispose of any unused or expired medication.
What is the usual dose of Adefovir?
The usual starting dose of Adefovir for adults is 10 mg once daily. Your doctor may adjust your dose based on your response to the medication and any side effects you experience. Always follow your doctor's specific dosing instructions for your personal health needs. If you have any questions about your dose, consult your healthcare provider.
Warnings and Precautions
Can Adefovir be taken safely while breastfeeding?
Adefovir is not recommended while breastfeeding. There's limited information on whether it passes into human breast milk. If you're taking Adefovir and want to breastfeed, talk with your doctor about safer medication options that would allow you to nurse your baby safely. Your doctor can help determine the best treatment plan for you and your baby.
Can Adefovir be taken safely while pregnant?
Adefovir is not recommended during pregnancy unless the benefits outweigh the risks. There's limited information on its safety in pregnant women. If you're pregnant or planning to become pregnant, talk with your doctor about the safest way to manage your condition. Your doctor can help create a treatment plan that protects both you and your baby.
Can I take Adefovir with other prescription drugs?
Adefovir can interact with other medications that affect kidney function, increasing the risk of kidney problems. It's important to inform your doctor about all the medications you're taking, including over-the-counter drugs and supplements. Your doctor can help manage any potential interactions and adjust your treatment plan as needed.
Does Adefovir have adverse effects?
Adverse effects are unwanted reactions to a medication. Common adverse effects of Adefovir include nausea, headache, and abdominal pain. These effects are usually mild. Serious side effects, like kidney or liver problems, are rare but require immediate medical attention. Always inform your doctor about any new or worsening symptoms while taking Adefovir.
Does Adefovir have any safety warnings?
Yes, Adefovir has important safety warnings. It can cause kidney problems, so regular monitoring of kidney function is necessary. If you experience symptoms like nausea, vomiting, or changes in urination, contact your doctor. Adefovir can also cause liver problems, so watch for signs like yellowing of the skin or eyes. Always follow your doctor's advice and report any new or worsening symptoms.
Is Adefovir addictive?
Adefovir is not addictive or habit-forming. This medication doesn't cause dependency or withdrawal symptoms when you stop taking it. Adefovir works by affecting your liver to help control viral infections. This mechanism doesn't affect brain chemistry in ways that could lead to addiction. If you have concerns about medication dependence, you can feel confident that Adefovir doesn't carry this risk.
Is Adefovir safe for the elderly?
Elderly individuals may be more vulnerable to the side effects of Adefovir, such as kidney problems. Regular monitoring of kidney function is important for elderly patients taking this medication. If you are elderly and taking Adefovir, your doctor will closely monitor your health to ensure the medication is safe and effective for you.
Is it safe to drink alcohol while taking Adefovir?
It's best to avoid alcohol while taking Adefovir. Alcohol can increase the risk of liver damage, which is a concern for people with hepatitis B. Drinking alcohol can also worsen side effects like dizziness or nausea. If you do choose to drink occasionally, limit how much alcohol you consume and talk with your doctor about alcohol use while taking Adefovir.
Is it safe to exercise while taking Adefovir?
You can exercise while taking Adefovir, but keep a few things in mind. Adefovir can cause dizziness or fatigue, which might affect your exercise capacity. To exercise safely, drink plenty of water and watch for signs of dizziness or unusual fatigue. If you notice these symptoms, slow down or stop exercising and rest. Check with your doctor if you have concerns.
Is it safe to stop Adefovir?
Stopping Adefovir suddenly can cause your viral infection to worsen. It's important to follow your doctor's instructions and not stop taking the medication without consulting them. Your doctor might suggest gradually reducing your dose or switching to a different medication to keep your condition under control. Always talk with your doctor before making any changes to your medication.
What are the most common side effects of Adefovir?
Side effects are unwanted reactions that can happen when taking a medication. Common side effects of Adefovir include headache, nausea, and abdominal pain. These effects vary from person to person and are usually mild. If you notice new symptoms after starting Adefovir, they might be temporary or unrelated to the medication. Talk with your doctor before stopping any medication.
Who should avoid taking Adefovir?
Adefovir should not be used by people with severe kidney problems, as it can worsen kidney function. It's also contraindicated in individuals allergic to Adefovir or its ingredients. Pregnant or breastfeeding women should avoid Adefovir unless the benefits outweigh the risks. Always consult your doctor about any concerns or conditions before starting Adefovir.
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