Acitretin
Psoriasis
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Drug Status
Government Approvals
US(FDA), UK(BNF)
WHO Essential Medicine
NO
Known Teratogen
Definite
Pharmaceutical Class
Retinoid
Controlled Drug Substance
No
Acitretin
Summary
Acitretin is used to treat severe psoriasis, which is a skin condition causing red, scaly patches. It is often prescribed when other treatments have not been effective.
Acitretin works by slowing the growth of skin cells, which helps reduce the symptoms of psoriasis. It belongs to a class of drugs called retinoids, which are related to vitamin A.
The usual starting dose of Acitretin for adults is 25 to 50 mg once daily with food. The maximum recommended dose is 75 mg per day. It is taken orally, meaning by mouth.
Common side effects of Acitretin include dry skin, lips, and eyes. These effects occur in more than 10% of users and are considered unwanted reactions to the medication.
Acitretin can cause severe birth defects, so it is not safe during pregnancy. It can also cause liver damage, requiring regular liver function tests. Women of childbearing age must use effective birth control.
Indications and Purpose
How does Acitretin work?
Acitretin works by slowing the growth of skin cells, which helps reduce the symptoms of psoriasis. It belongs to a class of drugs called retinoids, which are related to vitamin A. Think of it like a traffic controller for skin cells, helping to regulate their production and shedding. This action improves the appearance of the skin and reduces scaling and redness. Acitretin is effective for severe psoriasis and is often used when other treatments haven't worked.
Is Acitretin effective?
Yes, Acitretin is effective for treating severe psoriasis, which is a skin condition causing red, scaly patches. It works by slowing the growth of skin cells. Clinical studies show that Acitretin improves skin appearance and reduces symptoms in many patients. The effectiveness of Acitretin can vary, and regular follow-ups with your doctor are important to monitor progress and adjust treatment as needed.
What is Acitretin?
Acitretin is a medication used to treat severe psoriasis, which is a skin condition causing red, scaly patches. It belongs to a class of drugs called retinoids, which are related to vitamin A. Acitretin works by slowing the growth of skin cells, helping to improve the appearance of the skin. It is usually used when other treatments have not been effective. Acitretin is taken orally and is often used in combination with other therapies for better results.
Directions for Use
For how long do I take Acitretin?
Acitretin is usually taken long-term for chronic skin conditions like psoriasis. The duration of use depends on your response and any side effects. Your doctor will determine how long you need to take Acitretin based on your condition and progress. Regular follow-ups are important to monitor your treatment and make any necessary adjustments. Always follow your doctor's guidance on the duration of Acitretin use.
How do I dispose of Acitretin?
Dispose of Acitretin by taking it to a drug take-back program or collection site at a pharmacy or hospital. If these options aren't available, you can throw it in the trash at home. First, remove it from its original container, mix it with something undesirable like used coffee grounds, seal it in a plastic bag, and then throw it away. This helps prevent harm to people and the environment.
How do I take Acitretin?
Take Acitretin once daily with food to improve absorption. Swallow the capsule whole; do not crush or chew it. If you miss a dose, take it as soon as you remember, unless it's close to your next dose. In that case, skip the missed dose and continue your regular schedule. Do not take two doses at once. Avoid alcohol while on Acitretin, as it can increase the risk of side effects. Follow your doctor's specific instructions for taking this medication.
How long does it take for Acitretin to start working?
Acitretin may take several weeks to show noticeable improvements in your skin condition. The full therapeutic effect can take up to three to six months. Individual factors like the severity of your condition and your body's response can affect how quickly you see results. Be patient and continue taking Acitretin as prescribed. Regular follow-ups with your doctor will help monitor your progress and adjust treatment if needed.
How should I store Acitretin?
Store Acitretin at room temperature, away from moisture and light. Keep it in a tightly closed container. Do not store it in the bathroom, where humidity can affect the medication. Keep it out of reach of children and pets. Check the expiration date regularly and dispose of any unused or expired medication properly. Follow your pharmacist's instructions for safe storage.
What is the usual dose of Acitretin?
The usual starting dose of Acitretin for adults is 25 to 50 mg once daily with food. Your doctor may adjust the dose based on your response and tolerance. The maximum recommended dose is 75 mg per day. Acitretin is not typically used in children. Elderly patients may require careful monitoring due to potential side effects. Always follow your doctor's specific dosing instructions for your health needs.
Warnings and Precautions
Can Acitretin be taken safely while breastfeeding?
No, Acitretin is not recommended while breastfeeding. It can pass into breast milk and may harm the baby. The effects on milk supply are not well-studied, but potential risks to the infant's development exist. If you're taking Acitretin and wish to breastfeed, talk with your doctor about safer medication options that allow you to nurse safely.
Can Acitretin be taken safely while pregnant?
No, Acitretin is not safe during pregnancy. It can cause severe birth defects. Women of childbearing age must use effective birth control before, during, and after treatment. If you become pregnant while taking Acitretin, contact your doctor immediately. Always discuss pregnancy plans with your doctor before starting Acitretin to ensure safe treatment options.
Can I take Acitretin with other prescription drugs?
Acitretin can interact with several medications. Avoid taking it with methotrexate, which can increase the risk of liver damage. Tetracycline antibiotics can increase the risk of increased pressure in the brain. Acitretin can also interact with alcohol, increasing the risk of side effects. Always inform your doctor about all medications you are taking to prevent potential interactions and ensure safe treatment.
Does Acitretin have adverse effects?
Yes, Acitretin can cause adverse effects, which are unwanted reactions to a medication. Common adverse effects include dry skin, lips, and eyes. Serious side effects can include liver damage and severe birth defects. If you notice any new or worsening symptoms, contact your doctor immediately. Regular monitoring and communication with your healthcare provider can help manage these effects and ensure safe use of Acitretin.
Does Acitretin have any safety warnings?
Yes, Acitretin has important safety warnings. It can cause severe birth defects, so it is not safe for use during pregnancy. Women of childbearing age must use effective birth control before, during, and after treatment. Acitretin can also cause liver damage, so regular liver function tests are necessary. Not adhering to these warnings can lead to serious health risks. Always follow your doctor's advice and report any unusual symptoms immediately.
Is Acitretin addictive?
No, Acitretin is not addictive or habit-forming. It does not cause dependency or withdrawal symptoms when you stop taking it. Acitretin works by affecting skin cell growth and does not impact brain chemistry in ways that could lead to addiction. You won't experience cravings for this medication or feel compelled to take more than prescribed. If you have concerns about medication dependence, Acitretin does not carry this risk.
Is Acitretin safe for the elderly?
Elderly patients may be more vulnerable to the side effects of Acitretin, such as liver damage and increased cholesterol levels. Regular monitoring and dose adjustments may be necessary. The elderly should use Acitretin with caution and under close medical supervision. Discuss any concerns with your doctor to ensure safe and effective treatment.
Is it safe to drink alcohol while taking Acitretin?
No, it's best to avoid alcohol while taking Acitretin. Alcohol can increase the risk of liver damage and other side effects. It may also interfere with the medication's effectiveness. If you choose to drink occasionally, limit your alcohol intake and discuss it with your doctor. They can provide personalized advice based on your health situation.
Is it safe to exercise while taking Acitretin?
Yes, you can exercise while taking Acitretin, but be mindful of potential side effects like joint pain or dry skin, which may affect your comfort during physical activity. Stay hydrated and avoid strenuous activities if you experience discomfort. Listen to your body and rest if needed. Consult your doctor if you have concerns about exercising while on Acitretin.
Is it safe to stop Acitretin?
Stopping Acitretin suddenly is generally safe, but always consult your doctor first. Acitretin is used for long-term management of skin conditions like psoriasis. Stopping it may cause symptoms to return or worsen. There are no known withdrawal symptoms, but your doctor might suggest a gradual reduction in dose to monitor your condition. Always follow your doctor's guidance when making changes to your medication regimen.
What are the most common side effects of Acitretin?
Common side effects of Acitretin include dry skin, lips, and eyes. These effects occur in more than 10% of users. Side effects are unwanted reactions to a medication and can vary from person to person. If you experience new symptoms after starting Acitretin, they might be temporary or unrelated to the medication. Discuss any concerns with your doctor before stopping the medication.
Who should avoid taking Acitretin?
Acitretin is absolutely contraindicated in pregnancy due to the risk of severe birth defects. Women of childbearing age must use effective birth control. It's also contraindicated in patients with severe liver or kidney disease. Relative contraindications include high cholesterol and diabetes, where caution is needed. Always discuss your medical history with your doctor to determine if Acitretin is safe for you.
