Macorate CR 400 Tablet can be used alone or in combination with other medications It can be taken with or without food Your doctor will determine the appropriate dosage for you which may gradually increase until your condition stabilizes It may take several weeks for this medication to take effect so it is important to take it regularly in order to reap its benefits Unless advised by your doctor do not stop taking this medication even if you feel well Abruptly discontinuing it may lead to more seizures or worsen your bipolar disorder The most common side effects of Macorate CR 400 Tablet include skin rashes headaches nausea difficulty sleeping dizziness and drowsiness These side effects usually subside but if they persist or bother you notify your doctor There may be ways to prevent or minimize these effects Prolonged use of this medication may weaken your bones and increase the risk of osteoporosis and fractures Inform your doctor if you have kidney or liver problems meningitis depression or experience suicidal thoughts Also inform your healthcare team about any other medications you are taking as some may interact with or be affected by Macorate CR 400 Tablet including contraceptive pills If you are pregnant or breastfeeding your dosage may need adjustment If this medication causes drowsiness or dizziness avoid driving or riding a bicycle You may require frequent blood tests to monitor your response to this medication