The Macorate 400 Tablet can be used alone or in combination with other medications It can be taken with or without food as directed by your doctor The dosage will be determined by your doctor and may be gradually increased until your condition stabilizes It is important to take this medicine regularly even if you start feeling better Do not stop taking it without your doctors advice as it could lead to increased seizures or worsen your bipolar disorder Common side effects of this medicine may include skin rashes headaches nausea difficulty sleeping dizziness or drowsiness These side effects usually subside but if they persist or bother you inform your doctor There may be ways to prevent or reduce these side effects Prolonged use of this medication can weaken your bones and increase the risk of osteoporosis and fractures Before taking this medicine inform your doctor if you have kidney or liver problems meningitis depression or suicidal thoughts Also let your healthcare team know about all the medications you are currently using as some may interact with or be affected by Macorate 400 Tablet including contraceptive pills If you are pregnant or breastfeeding this medication can be taken if necessary but the dosage may need to be adjusted It is advisable to avoid driving or riding a bicycle if this medicine makes you drowsy or dizzy Regular blood tests may be required to monitor your response to this medication