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Kinsunate 60mg Injection
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Liver and Spleen Damage from Dengue: Pathogenesis
What are some common preventive measures that individuals can take to reduce the risk of dengue virus infection?
- Dengue virus, transmitted by mosquitoes, enters the human body through infected mosquito bites.
- The virus primarily infects white blood cells, specifically monocytes and macrophages, crucial for the immune response.
- Infected cells spread the virus to various body parts, including the liver and spleen.
- The liver filters blood and eliminates toxins, while the spleen filters blood and removes old or damaged red blood cells.
- Dengue virus causes inflammation and damage to liver and spleen cells, triggering an immune response.
- Immune cells release cytokines and chemokines, attracting more immune cells and causing further organ damage.
- Symptoms of liver and spleen damage include abdominal pain, nausea, vomiting, and jaundice.
- Severe cases may lead to liver failure and bleeding disorders.
- Preventive measures, such as using mosquito repellent and wearing protective clothing, are crucial to avoid dengue virus infection.
Disclaimer:- This information is intended to supplement, not substitute, advice from your healthcare provider or doctor. It does not cover all possible uses, precautions, interactions, or side effects, and may not be appropriate for your specific healthcare needs. Always consult with your doctor or another qualified healthcare provider before modifying or discontinuing any prescribed portion of your healthcare plan or treatment, in order to determine the best course of therapy for you. Do not ignore or delay professional medical advice based on anything you have seen or read on Medwiki.
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Malaria Cause, Signs, Transmission, Treatment and Prevention
Understanding Malaria: Symptoms, Transmission, and Risks
Malaria, a life-threatening disease transmitted by infected Anopheles mosquitoes. Symptoms range from mild to severe, including fever, chills, and confusion. Transmission can also occur through blood transfusion or contaminated needles.
Diagnosis and Tests:
- - Parasite-based testing confirms malaria, with blood tests identifying the parasite type, drug resistance, and organ impact.
- - Quick blood tests yield results in under 15 minutes, facilitating prompt treatment initiation.
Treatment:
- - Treatment varies based on parasite type, symptom severity, age, and pregnancy status. Antimalarial drugs like chloroquine, quinine sulfate, and artemisinin-based combinations are common.
Prevention:
- - Preventive measures include insect repellents, bed nets, and antimalarial medications.
- - Vaccines like RTS,S/AS01 and R21/Matrix-M are recommended in high transmission areas by WHO.
Watch our next video to know about Life Cycle of Malaria!
Source:-Fact sheet about malaria. (2024, March 1). Fact sheet about malaria. https://www.who.int/news-room/fact-sheets/detail/malaria
Disclaimer:-This information is not a substitute for medical advice. Consult your healthcare provider before making any changes to your treatment.Do not ignore or delay professional medical advice based on anything you have seen or read on Medwiki.
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Introduction to Kinsunate 60mg Injection
Kinsunate 60mg Injection contains Artesunate, which is a medication primarily utilized for the treatment of malaria, particularly in severe cases. Belonging to the artemisinin class of medications holds a place on the World Health Organization's List of Essential Medicines.
It functions as a prodrug, rapidly converting to its active form, dihydroartemisinin (DHA). This transformation generates reactive oxygen species, inducing oxidative stress and causing damage to malarial proteins. Additionally, it inhibits the essential Plasmodium falciparum exported protein 1 (EXP1), reducing parasite glutathione levels.
While generally well-tolerated, common side effects may include a slow heartbeat, allergic reactions, dizziness, and low white blood cell levels In severe cases, kidney failure requiring dialysis, hemoglobinuria (presence of hemoglobin in urine), and jaundice have been reported.
It is considered safe during pregnancy, particularly in the second and third trimesters, although caution is advised in the first trimester. It is generally safe for use in children, with adjustments in dosing for those under 20 kg. Notably, it should be avoided in newborns when combined with sulfadoxine/pyrimethamine due to potential effects on bilirubin.
In the event of a missed dose, it is crucial to consult with a healthcare professional for guidance on the appropriate course of action. The timing and severity of the missed dose will be considered to determine the most suitable response.
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Disclaimer : This information is not a substitute for medical advice. Consult your healthcare provider before making any changes to your treatment . Do not ignore or delay professional medical advice based on anything you have seen or read on Medwiki.
Kinsunate 60mg Injection
Prescription Required
Packaging :
vial of 1 Injection
Manufacturer :
Cureways RemediesComposition :
Artesunate (60mg)