You can take Depranil Plus 5 mg25 mg Tablet with or without food However it is recommended to take it at the same time every day to ensure a consistent level of medicine in your body Follow the dose and duration prescribed by your doctor as this medication can be habitforming If you happen to miss a dose take it as soon as you remember Make sure to complete the full course of treatment even if you start feeling better It is crucial not to stop taking this medication suddenly without consulting your doctor as it may cause withdrawal effects such as depression and difficulty sleeping Common side effects of Depranil Plus 5 mg25 mg Tablet include constipation difficulty in urination weight gain confusion and orthostatic hypotension sudden decrease in blood pressure upon standing This medication may also cause weight loss If you experience weight loss consider consulting a dietitian for dietary supplements or try increasing your food portion Most of these common side effects are usually mild but if they persist or bother you your doctor may be able to suggest ways to prevent or reduce them Serious side effects are rare but it is important to notify your doctor if you experience any unusual changes in mood as it may lead to suicidal thoughts If you have liver disease exercise caution while taking this medication Inform your doctor about all the other medicines you are taking as some of them may reduce the effectiveness of Depranil Plus 5 mg25 mg Tablet or alter its functioning If you are pregnant planning to become pregnant or breastfeeding inform your doctor about it