apraize (APREMILAST)

What is Apraize?

Apraize is a pill that helps treat a condition called psoriatic arthritis, which causes painful and swollen joints. It works by increasing the amount of a chemical in the body called cAMP. This chemical helps reduce inflammation and pain in the joints.

How do I take Apraize?

You can take Apraize with or without food. Swallow the tablets whole. Do not crush, split, or chew them.

For how long do I take Apraize?

Apraize is used up to 5 years in patients with psoriasis, psoriatic arthritis, or Behçet's syndrome for long term treatment.

What is Apraize used for?

Apraize is a medication used to treat three conditions:

1. Psoriatic Arthritis: A type of arthritis that causes pain, swelling, and stiffness in the joints, especially those of the fingers, toes, and spine.

2. Plaque Psoriasis: A skin condition that causes red, raised, scaly patches on the skin, often on the elbows, knees, and scalp.

3. Oral Ulcers Associated with Behçet's Disease: Painful sores in the mouth that occur as a symptom of Behçet's disease, a rare autoimmune disorder.

How long does it take for Apraize to start working?

Apraize typically starts showing noticeable effects within 2 to 4 weeks, but for some conditions, like psoriatic arthritis or plaque psoriasis, it may take up to 16 weeks to achieve full benefits. Regular use as prescribed is essential to see optimal results. Always consult your doctor if improvement seems delayed.

Is Apraize effective?

Yes, Apraize is effective for many people in managing conditions like psoriasis and psoriatic arthritis. It helps reduce inflammation, improve joint symptoms, and decrease the severity of skin plaques. While results vary, many patients notice improvement within 2–16 weeks of consistent use. Always follow your doctor’s guidance for the best outcomes.

How does one know if Apraize is working?

You can tell Apraize is working if you notice:

1. Reduced skin lesions – Decreased size or appearance of psoriasis patches.
2. Less joint pain – Reduced inflammation, pain, and swelling in psoriatic arthritis.
3. Improved mobility – Easier movement and less stiffness.

It may take 2 to 16 weeks to see noticeable improvements. Consult your doctor if symptoms don’t improve.

How does Apraize work?

Apraize works by inhibiting an enzyme called phosphodiesterase 4 (PDE4), which reduces the production of inflammatory chemicals in the body. This helps lower inflammation, relieving symptoms like joint pain, swelling, and skin lesions in conditions such as psoriasis and psoriatic arthritis.

Who should avoid taking Apraize?

People with an allergy to Apraize or other ingredients in the medicine should not take the medicine. Some people may have allergic reactions, including hives and swelling of the face, lips, tongue, or throat.

People 65 and older and those taking certain medications that can cause dehydration or low blood pressure may be at higher risk of problems from severe diarrhea, nausea, or vomiting.

The most common side effects of Apraize are diarrhea, nausea, headache, and vomiting.

Can I take Apraize with vitamins or supplements?

Apraize can generally be taken with vitamins or supplements. However, certain interactions may occur:

1. St. John's Wort – May reduce the effectiveness of Apraize.
2. Fish oil or omega-3 supplements – Can increase the risk of side effects like gastrointestinal discomfort.

Always inform your doctor about any vitamins or supplements you’re taking to ensure there are no harmful interactions with Apraize.

Can I take Apraize with other prescription drugs?

If you take Apraize with strong CYP450 inducers (such as rifampin, phenobarbital, carbamazepine, phenytoin), the amount of Apraize in your body will decrease. This can make Apraize less effective. Therefore, it's not recommended to take Apraize with these medications.

Can Apraize be taken safely while pregnant?

Apraize is not recommended during pregnancy unless necessary, as its safety is not well established. If you're pregnant or planning to get pregnant, consult your doctor to weigh the risks and benefits.

Can Apraize be taken safely while breastfeeding?

Apraize should be used with caution while breastfeeding, as it’s unclear if it passes into breast milk. It's best to consult your doctor before taking Apraize while breastfeeding to weigh potential risks and benefits.

Is Apraize safe for the elderly?

Apraize can generally be used by elderly patients, but they may be more susceptible to side effects, such as gastrointestinal issues or infections. Dose adjustments are typically not necessary, but careful monitoring is recommended. Always consult a doctor to assess the individual risks and ensure safe use.

How should I store Apraize?

Apraize should be stored at room temperature, away from moisture and heat, typically between 68°F to 77°F (20°C to 25°C). Keep it in its original container, tightly closed, and out of reach of children. Do not store it in the bathroom or near sources of heat or humidity.

Does Apraize make people tired or drowsy?

Apraize does not commonly cause tiredness or drowsiness. However, some people may experience headaches or mood changes, which could indirectly affect energy levels. If you feel unusually tired or drowsy while taking Apraize, consult your doctor to assess the cause and find possible solutions.

Does Apraize cause stomach upset?

Yes, Apraize can cause stomach upset, including side effects like nausea, diarrhea, and stomach pain. These are common, especially when starting the medication. If symptoms persist or worsen, consult your doctor for advice on managing these effects.

Does Apraize affect sleep?

Apraize is not commonly associated with sleep disturbances. However, some people may experience side effects like headache or mood changes, which could indirectly affect sleep. If you have trouble sleeping while taking Apraize, consult your doctor to assess the situation.

Does Apraize make it hard to think or concentrate?

Apraize can cause side effects like headache and mood changes, which may affect focus or concentration in some people. However, difficulty thinking or concentrating is not a common side effect. If you experience significant cognitive issues, contact your doctor for guidance.

Does Apraize affect mood?

Yes, Apraize can affect mood in some people, causing symptoms like depression, anxiety, or mood swings. If you experience significant mood changes, it’s important to talk to your doctor to evaluate the situation and adjust your treatment if necessary.

Does Apraize interfere with sexual function?

Apraize is not commonly associated with sexual function issues. However, some people may experience side effects like mood changes or fatigue, which could indirectly affect libido or sexual performance. If you notice any changes in sexual function while taking Apraize, consult your doctor for guidance.

Does Apraize affect appetite?

Apraize may cause weight loss in some people, which could affect appetite. This side effect is not very common but may occur. If you notice significant changes in appetite or weight, it’s important to consult your doctor to ensure there are no underlying issues.

Does Apraize cause weight gain?

Apraize is more commonly associated with weight loss rather than weight gain. Some individuals may experience a decrease in appetite or gastrointestinal issues, which can lead to weight loss. However, if you notice unexpected weight gain while taking Apraize, it’s important to consult your doctor.

Does Apraize cause headaches?

Yes, Apraize can cause headaches as a common side effect, especially when starting the medication. If headaches persist or become severe, consult your doctor to discuss possible adjustments or treatments to manage this side effect.

Does Apraize limit driving?

Apraize does not typically cause drowsiness or impair coordination, so it generally does not limit driving. However, if you experience side effects like headaches, dizziness, or mood changes, it may be best to avoid driving until you know how the medication affects you. Always consult your doctor if you're unsure.

What are Apraize possible harms and risks?

Apraize can cause side effects like diarrhea, headache, nausea, infections, mood changes, and weight loss. Consult your doctor if you experience any concerns.