What is the difference between Pirojen and tramadol?

Can Pirojen be used with Tizanidine?

Yes, Pirojen can be combined with tizanidine. Piroxicam is a pain killer and tizanidine is a skeletal muscle relaxant. It is used in the condition like a backache.

Are Pirojen and aspirin same?

No. Pirojen and aspirin are not same. They belong to the same class of drugs known as COX (cyclooxygenase) inhibitors. They both are anti-inflammatory and analgesic.

What are the contraindications for Pirojen?

Contraindications to piroxicam are an allergy, bleeding tendency, duodenal/gastric/peptic ulcer, stomatitis, Systemic Lupus Erythematosus (SLE), ulcerative colitis, upper GI disease, late pregnancy, cardiac disease, hepatic impairment, renal impairment.

Can Pirojen lead to skin reactions?

Yes. Pirojen is known to cause skin reactions which can be very severe such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. You should inform your doctor if you feel you have a mild rash and immediately discontinue the drug.

Can Pirojen be used to treat menstrual cramp?

Pirojen is not approved for the treatment of menstrual cramps. Research studies have shown that piroxicam is quite effective in significantly decreasing the menstrual cramps.

What is the difference between Pirojen and naproxen?

Both Pirojen and naproxen are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, gastric side effects are lesser with naproxen as compared to Pirojen.

Can you donate blood when on the medication with Pirojen?

Yes. You can donate blood when on Pirojen. Do inform your doctor before donating blood.

Is Pirojen a NSAID?

Yes. Pirojen is a non-steroidal anti-inflammatory drug (NSAID).

Is Pirojen a sulfa drug?

Pirojen is a sulphur containing compound. Pirojen can cause serious adverse events in sensitive individuals. It can cause severe skin reactions like Steven Johnson Syndrome. Do inform your doctor if you have any kind of allergies.

Is Pirojen a muscle relaxant?

No. Pirojen is not a muscle relaxant. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme.

Can Pirojen be used along with dexamethasone?

No. Pirojen should not be used with dexamethasone. They both increase each others toxicity. There is an increased risk of GI ulceration.

What is the difference between Pirojen and nimesulide?

Both Pirojen and nimesulide are pain killers. However, Pirojen is a non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain) inhibitor whereas nimesulide is selective to the COX-2 enzyme. This selectivity of nimesulide is supposed to decrease the side effects as compared to piroxicam. It should not be used in children below 12 years of age.

Can Pirojen be used in the treatment of chikungunya?

Usually, the platelet count does not dip in cases of chikungunya and painkillers like piroxicam can lead to the risk of increased bleeding tendency. So refrain from taking Pirojen or any painkiller in the case of any fever with joint pain. Consult your doctor before starting Pirojen.

Can Pirojen be used with methocarbamol?

Yes. Methocarbamol can be used with Pirojen as no serious side effects are known. Inform your doctor before starting any of the medication.

Can Pirojen be used along with paracetamol?

Yes. Paracetamol can be used with Pirojen as no serious side effects are known. Inform your doctor before starting any of the medication.

Can Pirojen be used with warfarin?

No. Pirojen should be avoided with warfarin as they both lead to increase in bleeding tendencies. Inform your doctor if you are taking any of the medications. If given together then the therapy should be monitored closely.

Can Pirojen be used in the treatment of allergy?

No. Pirojen is not a drug to treat allergy. It is a pain killer.

Can I use Pirojen if I have asthma?

Some patients with asthma are hypersensitive to non-steroidal anti-inflammatory (NSAID) drugs like aspirin which can lead to acute attacks of asthma. Consult your doctor before starting this medication.

Can Pirojen be used with lithium?

No. Pirojen should not be used with lithium. Pirojen leads to an elevation of plasma lithium levels and a reduction in renal lithium clearance. This is because of inhibition of renal prostaglandin synthesis by the NSAID. Consult and inform your doctor before starting this medication.

Are there any alternatives of Pirojen?

Yes. There are alternatives to Pirojen. Pain killers are prescribed according to the disease condition. Consult your doctor before starting piroxicam or changing it to other medication.

Can I use Pirojen if I have a deranged renal function?

No. Pirojen should not be taken if you have a abnormal renal function because long-term administration of NSAIDs has resulted in renal papillary necrosis and another renal injury.

Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAID)/ Pirojen?

Patients who had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine or for pain right before or after heart bypass surgery.

Can I use Pirojen if I have peptic ulcer disease?

No. Pirojen is contraindicated in cases of active peptic ulcer disease. Pirojen is known to cause gastric ulceration and bleeding.

What are the serious side effects of Pirojen?

GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, serious skin side effects such as exfoliative, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis, liver failure, renal damage.

Why is beta cyclodextrin added to Pirojen?

Yes. Pirojen can be combined with beta-cyclodextrin. Research has shown that combining Pirojen with beta-cyclodextrin leads to faster onset of action of piroxicam and reduced gastric side effects.

How long does Pirojen work?

Pirojen is a long acting drug. Once the daily dose is enough for the relief of pain but it depends from person to person as the effectiveness of piroxicam increases when given for few weeks.

Can Pirojen be used with calcium channel blocker?

Yes. Pirojen can be taken with calcium channel blocker. NSAIDs have been observed to reduce the effectiveness of all antihypertensive drugs except calcium channel blockers (ref: White 2007)

Can Pirojen be used with Lisinopril?

No. Pirojen should be avoided with lisinopril. It is important to note that piroxicam decreases the effectiveness of the antihypertensive medication like lisinopril when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting Pirojen.