Is PX a NSAID?

Can PX be used with lithium?

No. PX should not be used with lithium. PX leads to an elevation of plasma lithium levels and a reduction in renal lithium clearance. This is because of inhibition of renal prostaglandin synthesis by the NSAID. Consult and inform your doctor before starting this medication.

Can I use PX for a migraine?

PX is not approved for the treatment of migraine. Research studies have shown that PX is effective in significantly decreasing the pain associated with migraine without aura.

Can PX be used with Lisinopril?

No. PX should be avoided with lisinopril. It is important to note that piroxicam decreases the effectiveness of the antihypertensive medication like lisinopril when given together leading to failure of antihypertensive therapy. Inform your doctor if you are taking antihypertensive medications before starting PX.

Can PX be used in hypertension?

No. PX is not a medication to control hypertension. It is important to note that PX decreases the effectiveness of the antihypertensive medication when given together. Inform your doctor if you are taking antihypertensive medications before starting PX.

Can PX be used with methocarbamol?

Yes. Methocarbamol can be used with PX as no serious side effects are known. Inform your doctor before starting any of the medication.

Are there any alternatives of PX?

Yes. There are alternatives to PX. Pain killers are prescribed according to the disease condition. Consult your doctor before starting piroxicam or changing it to other medication.

Can PX be used to treat menstrual cramp?

PX is not approved for the treatment of menstrual cramps. Research studies have shown that piroxicam is quite effective in significantly decreasing the menstrual cramps.

Are PX and aspirin same?

No. PX and aspirin are not same. They belong to the same class of drugs known as COX (cyclooxygenase) inhibitors. They both are anti-inflammatory and analgesic.

What is the difference between PX and naproxen?

Both PX and naproxen are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, gastric side effects are lesser with naproxen as compared to PX.

Can you get high by using PX?

No. PX is not known to cause high. It is a non-narcotic painkiller.

Can PX lead to skin reactions?

Yes. PX is known to cause skin reactions which can be very severe such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. You should inform your doctor if you feel you have a mild rash and immediately discontinue the drug.

Is PX a sulfa drug?

PX is a sulphur containing compound. PX can cause serious adverse events in sensitive individuals. It can cause severe skin reactions like Steven Johnson Syndrome. Do inform your doctor if you have any kind of allergies.

How long does PX work?

PX is a long acting drug. Once the daily dose is enough for the relief of pain but it depends from person to person as the effectiveness of piroxicam increases when given for few weeks.

Can PX be used with Tizanidine?

Yes, PX can be combined with tizanidine. Piroxicam is a pain killer and tizanidine is a skeletal muscle relaxant. It is used in the condition like a backache.

Why is beta cyclodextrin added to PX?

Yes. PX can be combined with beta-cyclodextrin. Research has shown that combining PX with beta-cyclodextrin leads to faster onset of action of piroxicam and reduced gastric side effects.

Can I use PX if I am pregnant?

No. PX should not be taken in pregnancy. It causes premature closure of the ductus arteriosus which can lead to fetal heart failure and death of the baby.

What is the difference between PX and ketoprofen?

Both PX and ketoprofen are pain killers. Both are non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain). Research studies have shown ketoprofen topical gel is better and effective as compared to PX. Ketoprofen gel also showed excellent tolerability.

Can you donate blood when on the medication with PX?

Yes. You can donate blood when on PX. Do inform your doctor before donating blood.

What are the serious side effects of PX?

GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, serious skin side effects such as exfoliative, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis, liver failure, renal damage.

Can I use PX if I have a deranged renal function?

No. PX should not be taken if you have a abnormal renal function because long-term administration of NSAIDs has resulted in renal papillary necrosis and another renal injury.

Is PX a narcotic?

No. PX is not a narcotic. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme to decrease the pain and inflammation.

Can PX be used with warfarin?

No. PX should be avoided with warfarin as they both lead to increase in bleeding tendencies. Inform your doctor if you are taking any of the medications. If given together then the therapy should be monitored closely.

Can PX be used with diuretics?

No. PX should not be used with diuretics. PX reduces the natriuretic effect of furosemide and thiazides diuretics in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.

Can PX lead to difficulty in conception?

Yes. PX can sometimes cause reversible infertility. Piroxicam by its mechanism of action may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consult your doctor before starting this medication.

Can PX be used with calcium channel blocker?

Yes. PX can be taken with calcium channel blocker. NSAIDs have been observed to reduce the effectiveness of all antihypertensive drugs except calcium channel blockers (ref: White 2007)