
Does domperidone affect fertility?
Nov 3, 2023
Does domperidone affect fertility?
A comprehensive study published in XP 002238938 in 1980 examined the impact of varying doses of domperidone ranging from 03 to 10 mgkg on the mating rate and fertility rate of rats The findings of this study revealed a noticeable decrease in the mating rate with the extent of the decrease being dependent on the administered dose Surprisingly however the fertility rate remained unaffected These results shed light on the potential effects of domperidone on reproductive capabilities It appears that while the ability of rats to engage in mating activities may be hindered by the administration of higher doses their overall ability to conceive and reproduce remains unaffected Understanding the impact of domperidone on fertility is of utmost importance as this drug is commonly used to alleviate gastrointestinal issues The studys findings serve as a valuable resource for researchers and medical professionals alike providing insights into the potential effects of domperidone on reproductive health Further research and exploration may be required to determine whether these results are applicable to other mammals or species Additionally investigating the underlying mechanisms through which domperidone impacts mating rate without affecting fertility rate could provide additional insights into the drugs pharmacological effects In summary the study demonstrates that domperidone can lower the mating rate in rats in a dosedependent manner highlighting the need for caution when using this medication However it should be noted that the fertility rate of these animals remains unaffected suggesting that the drugs impact on reproduction may be limited
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