Can nicorandil cause bradycardia?
Nov 3, 2023
Can nicorandil cause bradycardia?
Singer et al 1 have documented several instances of hyperkalemia a potentially lifethreatening condition characterized by elevated levels of potassium in the blood and associated hemodynamic disturbances These cases were attributed to the activation of KATP channels which regulate the flow of potassium ions across cell membranes Similarly Lee et al 2 reported a specific case involving nicorandil a medication used to treat angina where severe bradycardia abnormally slow heart rate was induced by hyperkalemia This alarming event highlights the potential risks associated with the use of nicorandil and the importance of closely monitoring potassium levels in patients receiving this medication These studies shed light on the potential lifethreatening consequences of KATP channels activation and nicorandilinduced hyperkalemia underscoring the need for healthcare professionals to be vigilant in monitoring potassium levels and promptly addressing any abnormalities to prevent serious complications
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