Can I use Pam if I have peptic ulcer disease?

Can Pam be used with diuretics?

No. Pam should not be used with diuretics. Pam reduces the natriuretic effect of furosemide and thiazides diuretics in some patients. This response has been attributed to inhibition of renal prostaglandin synthesis.

Can Pam be used with methocarbamol?

Yes. Methocarbamol can be used with Pam as no serious side effects are known. Inform your doctor before starting any of the medication.

What are the contraindications for Pam?

Contraindications to piroxicam are an allergy, bleeding tendency, duodenal/gastric/peptic ulcer, stomatitis, Systemic Lupus Erythematosus (SLE), ulcerative colitis, upper GI disease, late pregnancy, cardiac disease, hepatic impairment, renal impairment.

Is Pam a sulfa drug?

Pam is a sulphur containing compound. Pam can cause serious adverse events in sensitive individuals. It can cause severe skin reactions like Steven Johnson Syndrome. Do inform your doctor if you have any kind of allergies.

Is Pam a narcotic?

No. Pam is not a narcotic. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme to decrease the pain and inflammation.

What increases the chances of getting a gastric ulcer when I am already taking Pam?

The chances of gastric ulceration increases if you take medicines like corticosteroids and anticoagulants. Long term use, alcohol, smoking and old age are few other factors which can increase the chances of ulceration.

Are Pam and aspirin same?

No. Pam and aspirin are not same. They belong to the same class of drugs known as COX (cyclooxygenase) inhibitors. They both are anti-inflammatory and analgesic.

Is Pam a muscle relaxant?

No. Pam is not a muscle relaxant. It is a pain killer which acts on COX (cyclooxygenase -an enzyme responsible for inflammation and pain) enzyme.

Can Pam be used along with dexamethasone?

No. Pam should not be used with dexamethasone. They both increase each others toxicity. There is an increased risk of GI ulceration.

Can Pam be used with lithium?

No. Pam should not be used with lithium. Pam leads to an elevation of plasma lithium levels and a reduction in renal lithium clearance. This is because of inhibition of renal prostaglandin synthesis by the NSAID. Consult and inform your doctor before starting this medication.

Can Pam be used along with paracetamol?

Yes. Paracetamol can be used with Pam as no serious side effects are known. Inform your doctor before starting any of the medication.

Can Pam be used with Tizanidine?

Yes, Pam can be combined with tizanidine. Piroxicam is a pain killer and tizanidine is a skeletal muscle relaxant. It is used in the condition like a backache.

Can Pam be used to treat menstrual cramp?

Pam is not approved for the treatment of menstrual cramps. Research studies have shown that piroxicam is quite effective in significantly decreasing the menstrual cramps.

How long does Pam work?

Pam is a long acting drug. Once the daily dose is enough for the relief of pain but it depends from person to person as the effectiveness of piroxicam increases when given for few weeks.

Can Pam be used with calcium channel blocker?

Yes. Pam can be taken with calcium channel blocker. NSAIDs have been observed to reduce the effectiveness of all antihypertensive drugs except calcium channel blockers (ref: White 2007)

What is the difference between Pam and naproxen?

Both Pam and naproxen are pain killers. Both are non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain). Research studies have shown both are equally effective. However, gastric side effects are lesser with naproxen as compared to Pam.

What is the difference between Pam and diclofenac?

Both Pam and diclofenac are pain killers. However, piroxicam is a non-selective COX (cyclooxygenase - an enzyme responsible for inflammation and pain) inhibitor whereas diclofenac has a bit more selectivity to a COX-2 enzyme. This selectivity of diclofenac is supposed to decrease the side effects as compared to Pam.

Are there any alternatives of Pam?

Yes. There are alternatives to Pam. Pain killers are prescribed according to the disease condition. Consult your doctor before starting piroxicam or changing it to other medication.

Can Pam be used in the treatment of allergy?

No. Pam is not a drug to treat allergy. It is a pain killer.

Can I use Pam if I am a diabetic?

Pam in a diabetic patient can only be taken only by consulting a doctor because these medicines have the propensity to cause renal failure when taken for a long period. Diabetes itself causes renal Pam so taking piroxicam can lead to increased risk of renal failure by many folds.

Can I use Pam for a migraine?

Pam is not approved for the treatment of migraine. Research studies have shown that Pam is effective in significantly decreasing the pain associated with migraine without aura.

Can you get high by using Pam?

No. Pam is not known to cause high. It is a non-narcotic painkiller.

Can I use Pam if I have asthma?

Some patients with asthma are hypersensitive to non-steroidal anti-inflammatory (NSAID) drugs like aspirin which can lead to acute attacks of asthma. Consult your doctor before starting this medication.

Can I use Pam if I have a deranged renal function?

No. Pam should not be taken if you have a abnormal renal function because long-term administration of NSAIDs has resulted in renal papillary necrosis and another renal injury.

Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAID)/ Pam?

Patients who had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine or for pain right before or after heart bypass surgery.

Why is beta cyclodextrin added to Pam?

Yes. Pam can be combined with beta-cyclodextrin. Research has shown that combining Pam with beta-cyclodextrin leads to faster onset of action of piroxicam and reduced gastric side effects.

What are the serious side effects of Pam?

GI discomfort and, rarely, serious GI side effects, such as ulcers and bleeding, serious skin side effects such as exfoliative, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis, liver failure, renal damage.

Is Pam a NSAID?

Yes. Pam is a non-steroidal anti-inflammatory drug (NSAID).

Is Pam a blood thinner?

No. Pam is not a blood thinner. It is a pain killer. It should be avoided in a patient with a bleeding disorder.

What is the difference between Pam and nimesulide?

Both Pam and nimesulide are pain killers. However, Pam is a non-selective COX (cyclooxygenase -an enzyme responsible for inflammation and pain) inhibitor whereas nimesulide is selective to the COX-2 enzyme. This selectivity of nimesulide is supposed to decrease the side effects as compared to piroxicam. It should not be used in children below 12 years of age.

Can Pam lead to skin reactions?

Yes. Pam is known to cause skin reactions which can be very severe such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. These serious events may occur without warning. You should inform your doctor if you feel you have a mild rash and immediately discontinue the drug.