predomide (THALIDOMIDE)
What is Predomide?
Predomide is an immunomodulatory drug used to treat multiple myeloma and erythema nodosum leprosum (ENL). It strengthens the immune system to fight cancer cells and reduces inflammation by blocking natural substances that cause swelling. Initially developed as a sedative, it was found to have severe teratogenic effects, leading to strict control of its use.
What is the usual dose of Predomide?
For multiple myeloma, the recommended dose is 200 mg once daily, taken at bedtime. For ENL, doses range from 100–300 mg daily, adjusted based on symptom severity and weight. Dosing for other conditions is determined individually by a healthcare provider.
How do I take Predomide?
Predomide capsules should be taken orally with water, preferably at bedtime or at least 1 hour after the evening meal. Patients taking it for ENL may need to divide the dose throughout the day. Avoid opening or handling broken capsules, as they can be harmful if absorbed through the skin.
For how long do I take Predomide?
Treatment duration depends on the condition being treated. For multiple myeloma or ENL, therapy may continue as long as there is a clinical benefit or until side effects require discontinuation. Tapering is often needed to prevent withdrawal effects.
What is Predomide used for?
Predomide is used with dexamethasone for newly diagnosed multiple myeloma. It also treats and prevents the skin symptoms of ENL, such as painful nodules and inflammation, and manages certain complications of leprosy.
How long does it take for Predomide to start working?
Predomide’s effects on multiple myeloma and ENL may be observed within weeks. Symptom improvement depends on the severity of the condition, with significant results often seen after 1–2 months of consistent use.
Is Predomide effective?
Clinical trials have demonstrated Predomide’s effectiveness in reducing cancer progression in multiple myeloma and controlling skin symptoms in ENL. Its combination with dexamethasone has shown a significant improvement in patient outcomes compared to dexamethasone alone.
How does one know if Predomide is working?
For multiple myeloma, effectiveness is evaluated by monitoring blood counts, bone marrow tests, and symptoms like fatigue. For ENL, a reduction in nodules and inflammation indicates progress. Regular doctor visits ensure proper monitoring.
How does Predomide work?
Predomide modulates the immune system by inhibiting the production of inflammatory cytokines, reducing inflammation. It also enhances the immune system’s ability to target cancer cells, aiding in the treatment of multiple myeloma.
Who should avoid taking Predomide?
Predomide is contraindicated in pregnant women due to its severe teratogenic effects. It should also be avoided by patients with severe neuropathy, hypersensitivity to the drug, or those at high risk for blood clots unless precautions are taken.
Can I take Predomide with vitamins or supplements?
Some supplements, like St. John’s Wort, can interact with Predomide and reduce its effectiveness. Always consult your doctor before taking vitamins, supplements, or herbal products while on this medication.
Can I take Predomide with other prescription drugs?
Predomide can interact with drugs that cause drowsiness (e.g., opioids, antihistamines) or increase blood clot risks (e.g., erythropoietic agents). Inform your doctor about all medications you’re taking to avoid harmful interactions.
Can Predomide be taken safely while pregnant?
No. Predomide causes severe birth defects, even with a single dose during pregnancy. Women of childbearing potential must use two forms of contraception and undergo regular pregnancy tests while taking this medication.
Can Predomide be taken safely while breastfeeding?
Predomide is not recommended while breastfeeding, as it may pass into breast milk and harm the baby. Women on Predomide should avoid breastfeeding during treatment.
Is Predomide safe for the elderly?
Elderly patients may require dose adjustments and close monitoring due to an increased risk of side effects, including neuropathy and blood clots. Doctors typically assess individual health factors before prescribing.
How should I store Predomide?
Store Predomide capsules at room temperature, away from moisture and heat. Keep them in their original packaging and out of reach of children. Do not use expired medication.
Does Predomide make people tired or drowsy?
Yes, drowsiness is a common side effect. If you feel excessively tired, avoid activities like driving or operating heavy machinery. Consult your doctor if this side effect persists or worsens.
Does Predomide cause stomach upset?
Yes, nausea and constipation are common gastrointestinal side effects. Drinking plenty of fluids, eating fiber-rich foods, and taking the medication with water can help. If symptoms persist, consult your doctor.
Does Predomide affect sleep?
Predomide may cause insomnia or excessive drowsiness. Patients should monitor their sleep patterns and inform their doctor if they experience significant disruptions.
Does Predomide make it hard to think or concentrate?
Confusion or difficulty concentrating can occur, especially in older adults. If these cognitive side effects interfere with daily life, consult your doctor for guidance or dose adjustments.
Does Predomide affect mood?
Mood changes, such as depression or anxiety, have been reported. If you notice significant emotional changes, discuss these with your doctor to evaluate possible causes and solutions.
Does Predomide interfere with sexual function?
Yes, difficulty achieving or maintaining an erection is a potential side effect. Inform your doctor if this issue arises, as alternative treatments or supportive measures may be available.
Does Predomide affect appetite?
Appetite changes, including loss of appetite, are possible. If this leads to significant weight changes or nutritional deficiencies, consult your doctor.
Does Predomide cause weight gain?
Weight gain or weight loss has been reported, though these effects are less common. Regular monitoring and lifestyle adjustments can help manage these changes.
Does Predomide cause headaches?
Most people tolerate this medicine well and headaches are not commonly reported. However, everybody can respond differently to medicines. Always track any changes you notice and let your doctor know when new symptoms are concerning - this will help make sure this medicine is right for you.
Does Predomide limit driving?
Yes, due to drowsiness and dizziness, driving or operating machinery is not recommended while taking Predomide, especially until you know how it affects you.
Is it safe to drink alcohol while taking Predomide?
Alcohol can worsen Predomide’s side effects, such as drowsiness and dizziness. It is best to avoid or limit alcohol while on this medication.
Is it safe to drink coffee or tea while taking Predomide?
Coffee and tea are generally safe but should be consumed in moderation, as excessive caffeine may worsen side effects like insomnia or restlessness.
Is it safe to exercise while taking Predomide?
Light to moderate exercise is generally safe but avoid intense physical activity if you experience side effects like dizziness, fatigue, or neuropathy. Always consult your doctor before starting a new exercise routine.
What are Predomide possible harms and risks?
Common side effects include drowsiness, dizziness, constipation, and neuropathy. Serious risks include severe birth defects, blood clots, and nerve damage, which can be permanent. Peripheral neuropathy occurs in more than 10% of patients, and blood clot risk is higher with certain cancer treatments.
Available in 2 variations
Predomide 50mg Tablet
Predomide 50mg Tablet
Thalidomide (50mg)
strip of 10 tablets
Predomide 100mg Tablet
Predomide 100mg Tablet
Thalidomide (100mg)
strip of 10 tablets
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